Recent Advances on Natural Aryl-C-glycoside Scaffolds: Structure, Bioactivities, and Synthesis—A Comprehensive Review

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 21; p. 7439
• Main Author: Liu, Chen-Fu
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2022; MDPI
• Subjects: Acids; Antibiotics; Antiviral drugs; aryl-C-glycoside; bioactivity; Cancer; Cytotoxicity; Flavonoids; Glucose; Hydrocarbons; Hypoglycemia; Leukemia; Natural products; novel structures; Review; synthesis

Aryl-C-glycosides, of both synthetic and natural origin, are of great significance in medicinal chemistry owing to their unique structures and stability towards enzymatic and chemical hydrolysis as compared to O-glycosides. They are well-known antibiotics and potent enzyme inhibitors and possess a w...