Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa

• Published in: Eye (London) Vol. 32; no. 11; pp. 1772 - 1782
• Main Authors: Lange, Clemens Alexander Klaus, Lehnert, Patrick, Boneva, Stefaniya Konstantinova, Zhang, Peipei, Ludwig, Franziska, Boeker, Martin, Hoffmeier, Klaus, Horres, Ralf, Schlunck, Günther, Reinhard, Thomas, Böhringer, Daniel, Auw-Haedrich, Claudia
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2018; Nature Publishing Group
• Subjects: 13/51; 45/91; 631/208/199; 631/61/212; 631/67/1484; Adult; Aged; Angiogenesis; Association analysis; Carcinoma, Squamous Cell - metabolism; Clinical outcomes; Eye Neoplasms - metabolism; Eye Neoplasms - pathology; Female; Frizzled-related protein 1; Gene Expression Profiling; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Hypoxia-inducible factors; Immunohistochemistry; Kaplan-Meier Estimate; Laboratory Medicine; Lymphoma; Lymphoma, Non-Hodgkin - metabolism; Male; Medicine; Medicine & Public Health; Melanoma; Melanoma - metabolism; Metastases; Middle Aged; Nevus - metabolism; Ophthalmology; Papilloma - metabolism; Pharmaceutical Sciences/Technology; Prognosis; Squamous cell carcinoma; Surgery; Surgical Oncology; Transcription factors; Tumors; Vascular endothelial growth factor

Purpose To investigate the expression profile of the hypoxia-inducible transcription factor-1α (HIF-1α) and its downstream targets in malignancies of the ocular adnexa and to determine its relevance as a prognostic factor for clinical outcome. Methods We included 49 subjects with malignant tumours (...