Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

• Published in: Nutrition & diabetes Vol. 8; no. 1; pp. 47 - 10
• Main Authors: Lentferink, Y. E., van der Aa, M. P., van Mill, E. G. A. H., Knibbe, C. A. J., van der Vorst, M. M. J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.09.2018; Nature Publishing Group
• Subjects: 692/699/2743/393; 692/700/1720; 692/700/2817; Adolescent; Antidiabetics; Body Mass Index; Child; Clinical Nutrition; Diabetes; Epidemiology; Female; Humans; Hypoglycemic Agents - therapeutic use; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metformin - therapeutic use; Obesity; Off-Label Use; Pediatric Obesity - drug therapy; Pediatric Obesity - metabolism; Teenagers; Treatment Outcome

Background/Objectives Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month open label extension study following an 18 months randomized placebo-con...