Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 153; no. 3; pp. 723 - 731.e1
• Main Authors: Chang, Jeff, Leong, Rupert W., Wasinger, Valerie C., Ip, Matthew, Yang, Michael, Phan, Tri Giang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: Adult; Blood Sedimentation; C-Reactive Protein - metabolism; Case-Control Studies; CLE; Colitis, Ulcerative - diagnostic imaging; Colitis, Ulcerative - physiopathology; Colonoscopy; Crohn Disease - diagnostic imaging; Crohn Disease - physiopathology; Female; Gastroenterology and Hepatology; Humans; Intestinal Barrier Function; Intestinal Mucosa - metabolism; Intravital Microscopy; Leaky Gut; Male; Microscopy, Confocal; Middle Aged; Permeability; Prospective Studies; Severity of Illness Index; Small Intestine; Symptom Assessment; Wound Healing; CRP; Intestinal Barrier Function; CD; ESR; NSAID; IBD; CLS; IQR; TNF; UC; Leaky Gut; eCLE; IBS; CLE; Small Intestine; C-reactive protein; intestinal barrier function; FL; fluorescein leak; endoscope based confocal laser endomicroscopy; CDO; CDAI; Crohn's disease activity index; Crohn's disease endoscopic index score; inter-quartile range; ulcerative colitis; receiver operating characteristic; leaky gut; erythrocyte sedimentation rate; irritable bowel syndrome; ROC; partial Mayo; Crohn's disease; Confocal Leak Score; inflammatory bowel disease; cell junction enhancement; pMayo; tumor necrosis factor; small intestine; cell drop out; CDEIS; CJE

Many patients with inflammatory bowel diseases (IBD) have ongoing bowel symptoms of diarrhea or abdominal pain despite mucosal healing. We investigated whether impaired intestinal permeability contributes to these symptoms. We performed a prospective study of intestinal permeability, measured by end...