Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus
The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent o...
Saved in:
Published in | Frontiers in neuroanatomy Vol. 15; p. 701573 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Lausanne
Frontiers Research Foundation
07.07.2021
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB
1
receptors. As CB
1
receptors also mediate LTD at these synapses, both CB
1
and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. We tested this hypothesis in the MPP–GC synapses of mice lacking TRPV1 (TRPV1-/-). Unlike wild-type (WT) mice, low-frequency stimulation (10 min at 10 Hz) of TRPV1-/- MPP fibers elicited a form of long-term potentiation (LTP) that was dependent on (1) CB
1
receptors, (2) the endocannabinoid 2-arachidonoylglycerol (2-AG), (3) rearrangement of actin filaments, and (4) nitric oxide signaling. These functional changes were associated with an increase in the maximum binding efficacy of guanosine-5′-O-(3-[
35
S]thiotriphosphate) ([
35
S]GTPγS) stimulated by the CB
1
receptor agonist CP 55,940, and a significant decrease in receptor basal activation in the TRPV1-/- hippocampus. Finally, TRPV1-/- hippocampal synaptosomes showed an augmented level of the guanine nucleotide-binding (G) Gα
i1
, Gα
i2
, and Gα
i3
protein alpha subunits. Altogether, the lack of TRPV1 modifies CB
1
receptor signaling in the dentate gyrus and causes the shift from CB
1
receptor-mediated LTD to LTP at the MPP–GC synapses. |
---|---|
AbstractList | The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB
1
receptors. As CB
1
receptors also mediate LTD at these synapses, both CB
1
and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. We tested this hypothesis in the MPP–GC synapses of mice lacking TRPV1 (TRPV1-/-). Unlike wild-type (WT) mice, low-frequency stimulation (10 min at 10 Hz) of TRPV1-/- MPP fibers elicited a form of long-term potentiation (LTP) that was dependent on (1) CB
1
receptors, (2) the endocannabinoid 2-arachidonoylglycerol (2-AG), (3) rearrangement of actin filaments, and (4) nitric oxide signaling. These functional changes were associated with an increase in the maximum binding efficacy of guanosine-5′-O-(3-[
35
S]thiotriphosphate) ([
35
S]GTPγS) stimulated by the CB
1
receptor agonist CP 55,940, and a significant decrease in receptor basal activation in the TRPV1-/- hippocampus. Finally, TRPV1-/- hippocampal synaptosomes showed an augmented level of the guanine nucleotide-binding (G) Gα
i1
, Gα
i2
, and Gα
i3
protein alpha subunits. Altogether, the lack of TRPV1 modifies CB
1
receptor signaling in the dentate gyrus and causes the shift from CB
1
receptor-mediated LTD to LTP at the MPP–GC synapses. The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, postsynaptic TRPV1 in granule cell dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of presynaptic cannabinoid CB1 receptors. As CB1 receptors also mediate LTD at these synapses, both CB1 and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. We tested this hypothesis in the MPP-granule cell synapses of mice lacking TRPV1 (TRPV1-/-). Unlike wild type (WT) mice, low frequency stimulation (10 min at 10 Hz) of TRPV1-/- MPP fibers elicited a form of long-term potentiation (LTP) that was dependent on 1) CB1 receptors, 2) the endocannabinoid 2-arachidonoylglycerol (2-AG), 3) rearrangement of actin filaments, and 4) nitric oxide signaling. These functional changes were associated with an increase in the maximum binding efficacy of guanosine-5´-O-(3-[35S]thiotriphosphate) ([35S]GTPγS) stimulated by the CB1 receptor agonist CP 55,940, and a significant decrease in receptor basal activation in the TRPV1-/- hippocampus. Finally, TRPV1-/- hippocampal synaptosomes showed an augmented level of the guanine nucleotide-binding (G) Gαi1, Gαi2 and Gαi3 protein alpha subunits. Altogether, the lack of TRPV1 modifies CB1 receptor signaling in the dentate gyrus and causes the shift from CB1 receptor-mediated LTD to LTP at the MPP-granule cell synapses The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB1 receptors. As CB1 receptors also mediate LTD at these synapses, both CB1 and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. We tested this hypothesis in the MPP–GC synapses of mice lacking TRPV1 (TRPV1-/-). Unlike wild-type (WT) mice, low-frequency stimulation (10 min at 10 Hz) of TRPV1-/- MPP fibers elicited a form of long-term potentiation (LTP) that was dependent on (1) CB1 receptors, (2) the endocannabinoid 2-arachidonoylglycerol (2-AG), (3) rearrangement of actin filaments, and (4) nitric oxide signaling. These functional changes were associated with an increase in the maximum binding efficacy of guanosine-5′-O-(3-[35S]thiotriphosphate) ([35S]GTPγS) stimulated by the CB1 receptor agonist CP 55,940, and a significant decrease in receptor basal activation in the TRPV1-/- hippocampus. Finally, TRPV1-/- hippocampal synaptosomes showed an augmented level of the guanine nucleotide-binding (G) Gαi1, Gαi2, and Gαi3 protein alpha subunits. Altogether, the lack of TRPV1 modifies CB1 receptor signaling in the dentate gyrus and causes the shift from CB1 receptor-mediated LTD to LTP at the MPP–GC synapses. |
Author | Elezgarai, Izaskun Egaña-Huguet, Jon Saumell-Esnaola, Miquel Grandes, Pedro Achicallende, Svein Soria-Gomez, Edgar Gerrikagoitia, Inmaculada Sallés, Joan Barrondo, Sergio Puente, Nagore Bonilla-Del Río, Itziar García del Caño, Gontzal |
AuthorAffiliation | 6 Department of Neurosciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU , Vitoria-Gasteiz , Spain 7 Division of Medical Sciences, University of Victoria , Victoria, BC , Canada 1 Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU , Leioa , Spain 4 Bioaraba, Neurofarmacología Celular y Molecular , Vitoria-Gasteiz , Spain 3 Department of Pharmacology, Faculty of Pharmacy, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU , Vitoria-Gasteiz , Spain 5 IKERBASQUE, Basque Foundation for Science , Bilbao , Spain 2 Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU , Leioa , Spain |
AuthorAffiliation_xml | – name: 4 Bioaraba, Neurofarmacología Celular y Molecular , Vitoria-Gasteiz , Spain – name: 1 Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU , Leioa , Spain – name: 3 Department of Pharmacology, Faculty of Pharmacy, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU , Vitoria-Gasteiz , Spain – name: 7 Division of Medical Sciences, University of Victoria , Victoria, BC , Canada – name: 5 IKERBASQUE, Basque Foundation for Science , Bilbao , Spain – name: 6 Department of Neurosciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU , Vitoria-Gasteiz , Spain – name: 2 Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU , Leioa , Spain |
Author_xml | – sequence: 1 givenname: Jon surname: Egaña-Huguet fullname: Egaña-Huguet, Jon – sequence: 2 givenname: Miquel surname: Saumell-Esnaola fullname: Saumell-Esnaola, Miquel – sequence: 3 givenname: Svein surname: Achicallende fullname: Achicallende, Svein – sequence: 4 givenname: Edgar surname: Soria-Gomez fullname: Soria-Gomez, Edgar – sequence: 5 givenname: Itziar surname: Bonilla-Del Río fullname: Bonilla-Del Río, Itziar – sequence: 6 givenname: Gontzal surname: García del Caño fullname: García del Caño, Gontzal – sequence: 7 givenname: Sergio surname: Barrondo fullname: Barrondo, Sergio – sequence: 8 givenname: Joan surname: Sallés fullname: Sallés, Joan – sequence: 9 givenname: Inmaculada surname: Gerrikagoitia fullname: Gerrikagoitia, Inmaculada – sequence: 10 givenname: Nagore surname: Puente fullname: Puente, Nagore – sequence: 11 givenname: Izaskun surname: Elezgarai fullname: Elezgarai, Izaskun – sequence: 12 givenname: Pedro surname: Grandes fullname: Grandes, Pedro |
BookMark | eNpdks1uEzEQx1eoiH7AA3CzxIVLgr93fUGCtLSVgqho4WrNer2Nw8ZebC8i78OD4iQFUU7jGf_m75nxnFZHPnhbVS8JnjPWqDe9Bw9ziimZ15iImj2pToiUdCYIVUf_nI-r05TWGEsqhXhWHTPOsBBMnVS_lmC-odCjvLLoLoJPzvqMPltjxxwiugm5-A4G9BW8G4bgOkTQ7cr1OaEFeA-t8yU4O7ej9d0u9-KncRlK8hbdbj2M2Rl0M0Aq1uUtcn7_1nlBIVt0uY1T-lPAxzAli95HKNCVG8dgYDNO6Xn1tIch2RcP9qz68uHibnE1W366vF68W84Mr3Geia4zRlHMAdfM1rUEgjnnkheX9ISwhtS8ByWw5HWjlJGtlNAQwjFIiyU7q64Pul2AtR6j20Dc6gBO7wMh3muIpY3Bam7bDpqeNoAZVwYay4VqrJK0a_u-a4vW24PWOLUb25nSboThkejjG-9W-j780A1VnChSBF4_CMTwfbIp641Lxg4DeFvGpKkoP8gYJaygr_5D12GKvoyqULxo8UbwQpEDZWJIKdr-bzEE690-6f0-6d0-6cM-sd-pNcEp |
CitedBy_id | crossref_primary_10_3390_ijms24043407 crossref_primary_10_1186_s12934_022_01914_1 crossref_primary_10_1007_s11064_023_04087_4 crossref_primary_10_3389_fncel_2022_864828 |
Cites_doi | 10.1523/JNEUROSCI.1299-11.2011 10.1126/science.1110449 10.1371/journal.pone.0000709 10.1152/jn.1996.76.6.3798 10.1038/nn.2616 10.1038/s41386-019-0530-5 10.1124/mol.110.068940 10.1523/JNEUROSCI.0176-06.2006 10.1523/ENEURO.0160-16.2016 10.1016/j.neuroscience.2020.02.019 10.1016/j.neuroscience.2006.02.074 10.1016/j.neuropharm.2019.04.020 10.1146/annurev.pharmtox.37.1.205 10.1016/j.neuron.2007.12.027 10.1016/j.cell.2012.01.037 10.1111/jnc.12137 10.1101/lm.050666.119 10.1016/j.neubiorev.2011.07.006 10.1152/physrev.00019.2008 10.1016/S0028-3908(00)00206-9 10.1146/annurev-neuro-062111-150420 10.1093/cercor/bhx126 10.1016/j.cellsig.2014.11.006 10.1124/mol.110.068304 10.3389/fnmol.2018.00487 10.1016/j.molbrainres.2004.12.003 10.1038/39807 10.1111/j.1476-5381.2010.01166.x 10.1038/nn.2685 10.1146/annurev.neuro.24.1.487 10.1523/JNEUROSCI.0257-19.2019 10.3389/fnana.2021.645940 10.3390/molecules24203672 10.1016/j.neuropharm.2007.06.026 10.1371/journal.pone.0119401 10.1074/jbc.M603220200 10.3389/fncel.2018.00182 10.1126/science.1099901 10.1016/j.biopsych.2015.07.028 10.1152/jn.1999.82.3.1569 10.1038/nn.2974 10.1016/j.neuropharm.2017.06.017 10.1523/JNEUROSCI.3635-14.2014 10.1016/S0165-6147(98)01240-1 10.1089/can.2017.0036 10.1007/s00429-014-0711-2 10.1523/JNEUROSCI.3303-06.2007 10.1073/pnas.0603861103 10.1006/bbrc.2000.4194 10.3390/biom10121609 10.1016/S0896-6273(03)00476-8 10.1038/nn.2684 |
ContentType | Journal Article |
Copyright | 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2021 Egaña-Huguet, Saumell-Esnaola, Achicallende, Soria-Gomez, Bonilla-Del Río, García del Caño, Barrondo, Sallés, Gerrikagoitia, Puente, Elezgarai and Grandes. 2021 Egaña-Huguet, Saumell-Esnaola, Achicallende, Soria-Gomez, Bonilla-Del Río, García del Caño, Barrondo, Sallés, Gerrikagoitia, Puente, Elezgarai and Grandes |
Copyright_xml | – notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2021 Egaña-Huguet, Saumell-Esnaola, Achicallende, Soria-Gomez, Bonilla-Del Río, García del Caño, Barrondo, Sallés, Gerrikagoitia, Puente, Elezgarai and Grandes. 2021 Egaña-Huguet, Saumell-Esnaola, Achicallende, Soria-Gomez, Bonilla-Del Río, García del Caño, Barrondo, Sallés, Gerrikagoitia, Puente, Elezgarai and Grandes |
DBID | AAYXX CITATION 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
DOI | 10.3389/fnana.2021.701573 |
DatabaseName | CrossRef ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) Biological Sciences Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Science Journals (Alumni Edition) ProQuest Central Student ProQuest Biological Science Collection ProQuest Central Basic ProQuest Central Essentials ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | CrossRef Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1662-5129 |
EndPage | 701573 |
ExternalDocumentID | oai_doaj_org_article_4ebda8f28a0349ca8e4598e962dbffdb 10_3389_fnana_2021_701573 |
GeographicLocations | United States--US |
GeographicLocations_xml | – name: United States--US |
GrantInformation_xml | – fundername: Eusko Jaurlaritza – fundername: Ikerbasque, Basque Foundation for Science – fundername: Ministerio de Econom�a y Competitividad – fundername: Ministerio de Ciencia e Innovaci�n – fundername: Instituto de Salud Carlos III – fundername: Euskal Herriko Unibertsitatea |
GroupedDBID | --- 29H 2WC 53G 5GY 5VS 88I 8FE 8FH 9T4 AAFWJ AAYXX ABUWG ACGFO ACGFS ACXDI ADBBV ADRAZ AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU CITATION CS3 DIK DWQXO E3Z EBS EJD EMOBN F5P GNUQQ GROUPED_DOAJ GX1 HCIFZ HYE IAO IEA IHR ISR ITC KQ8 LK8 M2P M48 M7P M~E O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC RNS RPM TR2 3V. 7XB 8FK PQEST PQUKI PRINS Q9U 7X8 5PM |
ID | FETCH-LOGICAL-c470t-5ddcc9204a073e776a10444640731f1138174fa950647899c6b66a81140a6e063 |
IEDL.DBID | RPM |
ISSN | 1662-5129 |
IngestDate | Thu Jul 04 21:11:35 EDT 2024 Tue Sep 17 21:21:53 EDT 2024 Sat Aug 17 03:58:30 EDT 2024 Wed Sep 25 01:07:01 EDT 2024 Fri Aug 23 01:46:23 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c470t-5ddcc9204a073e776a10444640731f1138174fa950647899c6b66a81140a6e063 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Emmanuel Valjent, Centre National de la Recherche Scientifique (CNRS), France Reviewed by: Motokazu Uchigashima, Niigata University, Japan; Ursula H. Winzer-Serhan, Texas A&M Health Science Center, United States |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294191/ |
PMID | 34305539 |
PQID | 2549134854 |
PQPubID | 4424405 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_4ebda8f28a0349ca8e4598e962dbffdb pubmedcentral_primary_oai_pubmedcentral_nih_gov_8294191 proquest_miscellaneous_2555333213 proquest_journals_2549134854 crossref_primary_10_3389_fnana_2021_701573 |
PublicationCentury | 2000 |
PublicationDate | 2021-07-07 |
PublicationDateYYYYMMDD | 2021-07-07 |
PublicationDate_xml | – month: 07 year: 2021 text: 2021-07-07 day: 07 |
PublicationDecade | 2020 |
PublicationPlace | Lausanne |
PublicationPlace_xml | – name: Lausanne |
PublicationTitle | Frontiers in neuroanatomy |
PublicationYear | 2021 |
Publisher | Frontiers Research Foundation Frontiers Media S.A |
Publisher_xml | – name: Frontiers Research Foundation – name: Frontiers Media S.A |
References | Puente (B44) 2011; 14 B22 Marsch (B36) 2007; 27 Jeske (B29) 2006; 281 Kano (B30) 2009; 89 Steindel (B51) 2013; 124 Wang (B54) 2016; 3 Canduela (B6) 2015; 10 Conn (B15) 1997; 37 Muller (B38) 2019; 11 Peñasco (B42) 2019; 153 Chanda (B10) 2010; 78 Lutzu (B34) 2021; 456 Lu (B33) 2016; 79 Chávez (B11) 2010; 13 Morales (B37) 2017; 2 Eichenbaum (B20) 2012; 36 Oliver (B39) 2020; 10 Blume (B4) 2015; 27 Tóth (B52) 2005; 135 Caterina (B7) 2001; 24 Christopoulos (B14) 1998; 19 Puente (B45) 2015; 220 Schlosburg (B49) 2010; 13 Katona (B31) 2012; 35 Garro (B24) 2001; 40 Hargreaves (B28) 2005; 308 Han (B27) 2012; 148 Patwardhan (B40) 2006; 103 Wang (B53) 2018; 28 Gibson (B25) 2008; 57 Reyes-Harde (B46) 1999; 82 Chavez (B12) 2014; 34 Ruparel (B47) 2011; 80 Chiu (B13) 2008; 54 Cui (B17) 2018; 12 Grueter (B26) 2010; 13 Macek (B35) 1996; 76 Cavanaugh (B9) 2011; 31 Fyhn (B23) 2004; 305 Araque (B1) 2017; 124 Bialecki (B3) 2020; 40 Caterina (B8) 1997; 389 Booth (B5) 2019; 24 Fontaine (B21) 2020; 27 Pertwee (B43) 2015 Peñasco (B41) 2020; 45 De Petrocellis (B18) 2011; 163 Lafourcade (B32) 2007; 2 Cristino (B16) 2006; 139 Bender (B2) 2006; 26 Egaña-Huguet (B19) 2021; 15 Sjöström (B50) 2003; 39 Sawada (B48) 2001; 280 |
References_xml | – volume: 31 start-page: 10119 year: 2011 ident: B9 article-title: Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1299-11.2011 contributor: fullname: Cavanaugh – volume: 308 start-page: 1792 year: 2005 ident: B28 article-title: Neuroscience: major dissociation between medial and lateral entorhinal input to dorsal hippocampus publication-title: Science doi: 10.1126/science.1110449 contributor: fullname: Hargreaves – volume: 2 start-page: e0000709 year: 2007 ident: B32 article-title: Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex publication-title: PLoS ONE doi: 10.1371/journal.pone.0000709 contributor: fullname: Lafourcade – volume: 76 start-page: 3798 year: 1996 ident: B35 article-title: Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses publication-title: J. Neurophysiol. doi: 10.1152/jn.1996.76.6.3798 contributor: fullname: Macek – volume: 13 start-page: 1113 year: 2010 ident: B49 article-title: Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system publication-title: Nat. Neurosci. doi: 10.1038/nn.2616 contributor: fullname: Schlosburg – volume: 45 start-page: 309 year: 2020 ident: B41 article-title: Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice publication-title: Neuropsychopharmacology doi: 10.1038/s41386-019-0530-5 contributor: fullname: Peñasco – start-page: 1 volume-title: Handbook of Experimental Pharmacology year: 2015 ident: B43 article-title: Endocannabinoids and their pharmacological actions, contributor: fullname: Pertwee – volume: 80 start-page: 117 year: 2011 ident: B47 article-title: Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine publication-title: Mol. Pharmacol. doi: 10.1124/mol.110.068940 contributor: fullname: Ruparel – volume: 26 start-page: 4166 year: 2006 ident: B2 article-title: Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0176-06.2006 contributor: fullname: Bender – volume: 3 start-page: 10049 year: 2016 ident: B54 article-title: A primary cortical input to hippocampus expresses a pathway-specific and endocannabinoid-dependent form of long-term potentiation publication-title: eNeuro doi: 10.1523/ENEURO.0160-16.2016 contributor: fullname: Wang – volume: 456 start-page: 27 year: 2021 ident: B34 article-title: Modulation of NMDA receptors by G-protein-coupled receptors: role in synaptic transmission, plasticity and beyond publication-title: Neuroscience doi: 10.1016/j.neuroscience.2020.02.019 contributor: fullname: Lutzu – volume: 139 start-page: 1405 year: 2006 ident: B16 article-title: Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.02.074 contributor: fullname: Cristino – volume: 153 start-page: 32 year: 2019 ident: B42 article-title: Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2019.04.020 contributor: fullname: Peñasco – volume: 37 start-page: 205 year: 1997 ident: B15 article-title: Pharmacology and functions of metabotropic glutamate receptors publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev.pharmtox.37.1.205 contributor: fullname: Conn – volume: 57 start-page: 746 year: 2008 ident: B25 article-title: TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons publication-title: Neuron doi: 10.1016/j.neuron.2007.12.027 contributor: fullname: Gibson – volume: 148 start-page: 1039 year: 2012 ident: B27 article-title: Acute cannabinoids impair working memory through astroglial CB 1 receptor modulation of hippocampal LTD publication-title: Cell doi: 10.1016/j.cell.2012.01.037 contributor: fullname: Han – volume: 124 start-page: 795 year: 2013 ident: B51 article-title: Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus publication-title: J. Neurochem. doi: 10.1111/jnc.12137 contributor: fullname: Steindel – volume: 27 start-page: 380 year: 2020 ident: B21 article-title: Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus publication-title: Learn. Mem. doi: 10.1101/lm.050666.119 contributor: fullname: Fontaine – volume: 36 start-page: 1597 year: 2012 ident: B20 article-title: Towards a functional organization of episodic memory in the medial temporal lobe publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2011.07.006 contributor: fullname: Eichenbaum – volume: 89 start-page: 309 year: 2009 ident: B30 article-title: Endocannabinoid-mediated control of synaptic transmission publication-title: Physiol. Rev. doi: 10.1152/physrev.00019.2008 contributor: fullname: Kano – volume: 40 start-page: 686 year: 2001 ident: B24 article-title: Regulation of phospholipase Cβ activity by muscarinic acetylcholine and 5-HT2 receptors in crude and synaptosomal membranes from human cerebral cortex publication-title: Neuropharmacology doi: 10.1016/S0028-3908(00)00206-9 contributor: fullname: Garro – volume: 35 start-page: 529 year: 2012 ident: B31 article-title: Multiple functions of endocannabinoid signaling in the brain publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev-neuro-062111-150420 contributor: fullname: Katona – volume: 28 start-page: 2253 year: 2018 ident: B53 article-title: Atypical endocannabinoid signaling initiates a new form of memory-related plasticity at a cortical input to hippocampus publication-title: Cereb. Cortex doi: 10.1093/cercor/bhx126 contributor: fullname: Wang – volume: 27 start-page: 716 year: 2015 ident: B4 article-title: Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2014.11.006 contributor: fullname: Blume – volume: 78 start-page: 996 year: 2010 ident: B10 article-title: Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system publication-title: Mol. Pharmacol. doi: 10.1124/mol.110.068304 contributor: fullname: Chanda – volume: 11 start-page: 487 year: 2019 ident: B38 article-title: Cannabinoid ligands targeting TRP channels publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2018.00487 contributor: fullname: Muller – volume: 135 start-page: 162 year: 2005 ident: B52 article-title: Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain publication-title: Mol. Brain Res. doi: 10.1016/j.molbrainres.2004.12.003 contributor: fullname: Tóth – volume: 389 start-page: 816 year: 1997 ident: B8 article-title: The capsaicin receptor: a heat-activated ion channel in the pain pathway publication-title: Nature doi: 10.1038/39807 contributor: fullname: Caterina – volume: 163 start-page: 1479 year: 2011 ident: B18 article-title: Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.01166.x contributor: fullname: De Petrocellis – volume: 13 start-page: 1519 year: 2010 ident: B26 article-title: Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens publication-title: Nat. Neurosci. doi: 10.1038/nn.2685 contributor: fullname: Grueter – volume: 24 start-page: 487 year: 2001 ident: B7 article-title: The vanilloid receptor: a molecular gateway to the pain pathway publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.24.1.487 contributor: fullname: Caterina – volume: 40 start-page: 729 year: 2020 ident: B3 article-title: Suppression of presynaptic glutamate release by postsynaptic metabotropic NMDA receptor signalling to pannexin-1 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0257-19.2019 contributor: fullname: Bialecki – volume: 15 start-page: 645940 year: 2021 ident: B19 article-title: The absence of the transient receptor potential vanilloid 1 directly impacts on the expression and localization of the endocannabinoid system in the mouse hippocampus publication-title: Front. Neuroanat. doi: 10.3389/fnana.2021.645940 contributor: fullname: Egaña-Huguet – volume: 24 start-page: 1 year: 2019 ident: B5 article-title: Cannabinoid receptor interacting protein 1a (CRIP1a): function and structure publication-title: Molecules doi: 10.3390/molecules24203672 contributor: fullname: Booth – volume: 54 start-page: 68 year: 2008 ident: B13 article-title: Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2007.06.026 contributor: fullname: Chiu – volume: 10 start-page: e0119401 year: 2015 ident: B6 article-title: Visualization by high resolution immunoelectron microscopy of the transient receptor potential vanilloid-1 at inhibitory synapses of the mouse dentate gyrus publication-title: PLoS ONE doi: 10.1371/journal.pone.0119401 contributor: fullname: Canduela – volume: 281 start-page: 32879 year: 2006 ident: B29 article-title: Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons publication-title: J. Biol. Chem. doi: 10.1074/jbc.M603220200 contributor: fullname: Jeske – volume: 12 start-page: 182 year: 2018 ident: B17 article-title: Endocannabinoid-LTP mediated by CB1 and TRPV1 receptors encodes for limited occurrences of coincident activity in neocortex publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2018.00182 contributor: fullname: Cui – volume: 305 start-page: 1258 year: 2004 ident: B23 article-title: Spatial representation in the entorhinal cortex publication-title: Science doi: 10.1126/science.1099901 contributor: fullname: Fyhn – volume: 79 start-page: 516 year: 2016 ident: B33 article-title: An introduction to the endogenous cannabinoid system publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.07.028 contributor: fullname: Lu – volume: 82 start-page: 1569 year: 1999 ident: B46 article-title: Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores publication-title: J. Neurophysiol. doi: 10.1152/jn.1999.82.3.1569 contributor: fullname: Reyes-Harde – volume: 14 start-page: 1542 year: 2011 ident: B44 article-title: Polymodal activation of the endocannabinoid system in the extended amygdala publication-title: Nat. Neurosci. doi: 10.1038/nn.2974 contributor: fullname: Puente – volume: 124 start-page: 13 year: 2017 ident: B1 article-title: Synaptic functions of endocannabinoid signaling in health and disease publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2017.06.017 contributor: fullname: Araque – volume: 34 start-page: 16621 year: 2014 ident: B12 article-title: Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3635-14.2014 contributor: fullname: Chavez – volume: 19 start-page: 351 year: 1998 ident: B14 article-title: Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log publication-title: Trends Pharmacol. Sci. doi: 10.1016/S0165-6147(98)01240-1 contributor: fullname: Christopoulos – volume: 2 start-page: 265 year: 2017 ident: B37 article-title: An update on Non-CB 1, Non-CB 2 cannabinoid related G-protein-coupled receptors publication-title: Cannabis Cannabinoid Res. doi: 10.1089/can.2017.0036 contributor: fullname: Morales – volume: 220 start-page: 1187 year: 2015 ident: B45 article-title: The transient receptor potential vanilloid-1 is localized at excitatory synapses in the mouse dentate gyrus publication-title: Brain Struct. Funct. doi: 10.1007/s00429-014-0711-2 contributor: fullname: Puente – volume: 27 start-page: 832 year: 2007 ident: B36 article-title: Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3303-06.2007 contributor: fullname: Marsch – ident: B22 – volume: 103 start-page: 11393 year: 2006 ident: B40 article-title: The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0603861103 contributor: fullname: Patwardhan – volume: 280 start-page: 798 year: 2001 ident: B48 article-title: cGMP-dependent protein kinase phosphorylates and inactivates RhoA publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2000.4194 contributor: fullname: Sawada – volume: 10 start-page: 1 year: 2020 ident: B39 article-title: Cannabinoid receptor interacting protein 1a (CRIP1a) in health and disease publication-title: Biomolecules doi: 10.3390/biom10121609 contributor: fullname: Oliver – volume: 39 start-page: 641 year: 2003 ident: B50 article-title: Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors publication-title: Neuron doi: 10.1016/S0896-6273(03)00476-8 contributor: fullname: Sjöström – volume: 13 start-page: 1511 year: 2010 ident: B11 article-title: TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus publication-title: Nat. Neurosci. doi: 10.1038/nn.2684 contributor: fullname: Chávez |
SSID | ssj0062655 |
Score | 2.3255072 |
Snippet | The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule... The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, postsynaptic TRPV1 in granule cell... |
SourceID | doaj pubmedcentral proquest crossref |
SourceType | Open Website Open Access Repository Aggregation Database |
StartPage | 701573 |
SubjectTerms | 2-Arachidonoylglycerol Actin Biotechnology Brain Cannabinoid CB1 receptors Capsaicin receptors CB1 receptor Cold Dendritic spines Dentate gyrus endovanilloid system excitatory synapses Experiments Filaments G proteins Guanine Hippocampus Long-term depression Long-term potentiation Neuroscience Nitric oxide Sucrose Synaptic depression Synaptic plasticity Synaptosomes Transient receptor potential proteins |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQT1wQUBALpTIS4oAUGmdtxz72kxWiqFIp6i1yHFuNaJ1ok5XI_-kPZcbJVs2JC1fbShyP7Xkvnnkm5COXaeUt50lugKtyxWRipC2BpXilU5G5bIkJzuc_5OqKf7sW14-u-sKYsFEeeBy4A-7KyiifKYNKKtYox4VWTsusKr2vyrj7MrElU-MeDChdiPEMEyiYPvDBBBQZytiXHPxfvpx5oSjWP0OY8_jIRw7n7Dl5NiFFejj28AV54sJLsnsYgCXfDfQTjbGb8af4Lrn_buxv2ngKcI5G94NpjhQwoWuBVNOLpseoIHjcLxPq29umriijlze17zt6bEIwQJChMDmZ7sTt6ekfi-lnzXqgl0MwsLNYegFQG6Ow-4HWIb7rJKYuOfp1WG-6bQfOm03n6BFePkFXdduCu7xrN90rcnV2-vN4lUz3LySW52mfiKqyVmcpN7APuDyXhqG6HB79LZlnDMX9uDdaxIRVra0spTQKGFZqpAPs85rshCa4N4R6z0vUNE9TK7j3qgSWUkovdMUqsClbkM9bexTtKLNRAD1B4xXReAUarxiNtyBHaLGHhqiQHQtg3hTTvCn-NW8WZG9r72Jatl2BbJktuRJ8QT48VMOCw1MUExwMH7QRAJGXGYN-5LN5MuvQvCbUN1G6W2WaA0N--z--4B15ioMSY4fzPbLTrzfuPSCkvtyPi-EvW34UiQ priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZKe-GCCgWxUJCREAeksHFiO8kJddstK0SrFaWot8hxbBrROuluViL_hx_KjDcp5MI1L3t37Jnv87wIectlWFrNeZAo4Ko8ZTJQUhfAUmyahSIyUYwJzmfncnHJP1-Jqx2yGHJhMKxy0IleUZe1xjPyKRIZFvNU8Kkq8BRAt9OPzV2A_aPQz9o303hA9iLG0WG7N5ufL78OWhlwuxBbryaQsmxqnXJYdihiHxKwiEk8sku-fP8Ic44jJv8xQaf75FGPHenRVtiPyY5xT8jBkQPefNvRd9RHc_pj8gPy-4vSP2ltKQA86g0SJj5SQImmAZpNl3WLcULwue_KVTc3dVVSRi-uK9uu6bFyTgFlhovBSd8lt6XzXxoT0upVRy86p0DXaLoE8I1x2W1HK-fHOvHJTIZ-6lab9TCBs3qzNnSG7SjoomoaMKC3zWb9lFyezr8dL4K-I0OgeRK2gShLrbMo5Ao0g0kSqRjWm0NnYMwsY1juj1uVCZ_CmmVaFlKqFDhXqKQBNPSM7LrameeEWssLrHIehlpwa9MCeEshrchKVmp4ZULeD_LIm23hjRwICwov98LLUXj5VngTMkOJ3T-INbP9hXr1I--3YM5NUarURqnCmjwwhuEiS00mo7Kwtiwm5HCQd95v5HX-d9lNyJv727AF0a-inIG_D54RAJrjiME8ktE6GU1ofMdV176YdxplHDjzi_8P_pI8xJ_r44STQ7LbrjbmFaChtnjdL_Q_GUgPdQ priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Pj5QwFG7W9eLFqKtxdDXdxHgwYaVQChyM2Z9OjGM2WcfsjZTSusTZgsAky__jH-p7HZgsyV48AgUKr-V9H33ve4S848IvjOLciyVwVZ4w4UmhcmApJkn9KNBBiAnOi-9ivuRfr6KrHTKWtxpeYHsvtcN6UstmdXj7p_8ME_4TMk7wtx-NlRYlhAJ2GIN3i8MH5GHAQ44DfsG3iwoA3V0RVCYE8C_wc5tFzvsvMXFTTs1_AkGnAZR3PNL5E_J4gJL0aGP7p2RH22dk78gCjb7p6XvqgjvdX_M98vebVL9pZSjgPer8E-ZBUgCNugbWTS-qDsOG4HI_pS1Xq6osKKOX16XpWnoirZXAoGGndzoUze3o2a3C_LSq6ellbyV8ehS9ACyOYdpdT0vr7nXqcps0_dI363bswKJat5oeY3UKOi_rGvzpTb1un5Pl-dmPk7k3FGjwFI_9zouKQqk08LmED4WOYyEZys_h2mDIDGOo_seNTCOX0ZqmSuRCyAQomC-FBnD0guzayuqXhBrDcxQ9930VcWOSHGhMLkyUFqxQcMqMfBjtkdUbHY4M-AsaL3PGy9B42cZ4M3KMFts2RAltt6NqfmXDjMy4zguZmCCRKNED99A8ShOdiqDIjSnyGdkf7Z2NwzJDOs1CnkR8Rg62h2FG4jKLtBpeH7SJAEOHAYN-xJNxMunQ9Igtr522dxKkHCj0q_953NfkEW65IOJ4n-x2zVq_AajU5W_dBPgHeSwUKw priority: 102 providerName: Scholars Portal |
Title | Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus |
URI | https://www.proquest.com/docview/2549134854/abstract/ https://search.proquest.com/docview/2555333213 https://pubmed.ncbi.nlm.nih.gov/PMC8294191 https://doaj.org/article/4ebda8f28a0349ca8e4598e962dbffdb |
Volume | 15 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Bb9MwFLa2ceGCgIEobJWREAektHFiO8lx7bpViE4VY6i3yHHsLaJ1oiaV1v_DD-XZTablyiWHxEksv2e_99nvfQ-hL5T7uZaUepEArEpjwj3BZQYoRceJzwIVhDbBeXHD53f0-4qtjhDrcmFc0L7MipFZb0ameHCxldVGjrs4sfFyMY2DhALOGB-j4ygMO4h-WH7BQWfscHwJ6CsZayOM5RcKyCgC0xfZwjmh47my9cGf2SJH2d_zM_tRks_MztVr9Kr1F_HFoV9v0JEyb9HphQGsvNnjr9hFcLqt8VP094eQf3CpMTh12Bkhm-yIwTNUFUBrvCwbGxsEn_stTLFel0WOCb59KHRT46kwRgBMhpveZVsZt8GzR2mT0MrtHt_ujYD1ReIlONw2FrvZ48K4f126BCaFr_fbXd11YFHuaoUntgQFnhdVBUZzU-3qd-juavZrOvfaKgyepJHfeCzPpUwCnwpYDVQUcUEsx5w9AAyJJsRS_FEtEubSVpNE8oxzEQPO8gVX4AG9RyemNOoDwlrTzDKb-75kVOs4A6yScc2SnOQSXhmgb5080upAtpECSLFyTJ0cUyvH9CDHAZpYiT01tDzZ7ka5vU9bbUmpynIR6yAWlocH_qEoS2KV8CDPtM6zATrr5J22k7dOLWYmIY0ZHaDPT49h2tmzFGEUDB-0AQUKw4BAP6KenvQ61H8C-uwIvFv9_fjfb35CL-1IuLDh6AydNNudOgfnqMmG6MVkdrP8OXSbC3C9XhG4Lmg8dNPkH3lIF6Y |
link.rule.ids | 230,315,733,786,790,870,891,2115,21416,24346,27957,27958,33779,33780,43840,53827,53829,74659 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELege4AXNBiIwgAjIR6QwvJhO8kTWreOAm1VsQ3tLXIce4vYnKxJJfr_8Idy56aDvPDqfNjJ2Xf3s-9-R8g7JvzCKMa8WAJWZUkgPClUDijFJKnPQx1GmOA8m4vJOft6wS-6DbemC6vc6kSnqItK4R75AQKZIGIJZ5_qWw-rRuHpaldC4z7ZYRFAlQHZGY3ni-9bXQzeOuebs0yAYumBsdIi2VAYfIzBDsZRzxo50v6ep9mPk_zH8Jzskkedx0gPNyJ-TO5p-4TsHVpAyzdr-p66GE63Ob5Hfk-l-kkrQ8Gto84MYbojBd9Q1wCu6aJqMToIXvdD2vL6uioLGtDTq9K0DT2S1koAytDoHXe1cVs6_qUwDa1arunp2krQMIouwOXGaOx2TUvr-jp2KUyafl4vV812ALNq1Wg6wiIUdFLWNZjNm3rVPCXnJ-Ozo4nX1WHwFIv91uNFoVQa-kyCPtBxLGSALHN4BBgFJgiQ5I8ZmXKXuJqmSuRCyASQli-FBh_oGRnYyurnhBrDcuQ2933FmTFJDmglF4anRVAoeGRIPmzlkdUbuo0MYAoKL3PCy1B42UZ4QzJCid3diEzZrqFaXmbdwsuYzguZmDCRyMQDfWjG00SnIixyY4p8SPa38s665dtkfyfbkLy9uwwLD09TpNXw--AeDq5yFAYwjrg3T3oD6l-x5ZWj8E7ClAFSfvH_zt-QB5Oz2TSbfpl_e0ke4qe7SOF4nwza5Uq_An-ozV93k_4PTpEOqA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELaglRAXBBTEQgEjIQ5IYfOwneSEut1dFmhXK0pRb5Hj2DSidcImK5H_ww9lxpst5MI1LzuZ8cz3xfMg5DUTfmEUY14sgauyJBCeFCoHlmKS1OehDiNMcD5disU5-3TBL_r4p6YPq9zZRGeoi0rhP_IxEpkgYglnY9OHRaym8_f1Tw87SOFOa99O4zbZj5ngoOH7k9ly9WVnlwG5c77d1wRalo6NlRYLD4XBuxh8YhwNPJMr4D9AncOYyX-c0Pw-udejR3q0FfcDckvbh-TgyAJzvu7oG-riOd2P8gPy-0SqH7QyFCAedS4JUx8p4ERdA9Gmq6rFSCF43Ddpy6urqixoQM8uS9M29FhaK4E0w0Fv2vfJbensl8KUtGrd0bPOSrA2iq4AfmNkdtvR0rqxpi6dSdMP3XrT7CZwWm0aTSfYkIIuyroGF3pdb5pH5Hw--3q88PqeDJ5isd96vCiUSkOfSbANOo6FDLDiHG4HRoEJAiz4x4xMuUtiTVMlciFkAqzLl0IDHnpM9mxl9RNCjWE51jn3fcWZMUkOzCUXhqdFUCi4ZUTe7uSR1dvSGxlQFhRe5oSXofCyrfBGZIISu7kQq2a7A9X6e9YvwozpvJCJCROJVXlgDM14muhUhEVuTJGPyOFO3lm_lJvsr-KNyKub07AIcWdFWg2fD67hAJujMIB5xAM9GUxoeMaWl66cdxKmDFjz0_8P_pLcAX3PTj4uPz8jd_HNXdBwfEj22vVGPwdo1OYvep3_A9LyEuU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lack+of+the+Transient+Receptor+Potential+Vanilloid+1+Shifts+Cannabinoid-Dependent+Excitatory+Synaptic+Plasticity+in+the+Dentate+Gyrus+of+the+Mouse+Brain+Hippocampus&rft.jtitle=Frontiers+in+neuroanatomy&rft.au=Ega%C3%B1a-Huguet%2C+Jon&rft.au=Saumell-Esnaola%2C+Miquel&rft.au=Achicallende%2C+Svein&rft.au=Soria-Gomez%2C+Edgar&rft.date=2021-07-07&rft.issn=1662-5129&rft.eissn=1662-5129&rft.volume=15&rft_id=info:doi/10.3389%2Ffnana.2021.701573&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fnana_2021_701573 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-5129&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-5129&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-5129&client=summon |