Serological Evidence of Japanese Encephalitis Virus Circulation in Asian Children From Dengue-Endemic Countries

Abstract Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete...

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Published inThe Journal of infectious diseases Vol. 219; no. 3; pp. 375 - 381
Main Authors Nealon, Joshua, Taurel, Anne-Frieda, Yoksan, Sutee, Moureau, Annick, Bonaparte, Matt, Quang, Luong Chan, Capeding, Maria R., Prayitno, Ari, Hadinegoro, Sri Rezeki, Chansinghakul, Danaya, Bouckenooghe, Alain
Format Journal Article
LanguageEnglish
Published US Oxford University Press 09.01.2019
Subjects
Adolescent
Asia - epidemiology
Child
Child, Preschool
Children
Dengue - epidemiology
Dengue - immunology
Dengue fever
Dengue Vaccines
Dengue Virus - immunology
Encephalitis
Encephalitis Virus, Japanese - immunology
Encephalitis, Japanese - epidemiology
Encephalitis, Japanese - immunology
Epidemiology
Humans
Indonesia - epidemiology
Infections
Major and Brief Reports
Malaysia - epidemiology
Neurological complications
Neurological diseases
Neutralization Tests
Pediatrics
Philippines - epidemiology
Prevalence
Seroepidemiologic Studies
Serology
Vietnam - epidemiology
VIRUSES
Vietnam
Malaysia
Asia
Philippines
Indonesia
epidemiology
encephalitis
Japanese
seroepidemiologic studies
flavivirus
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Abstract Abstract Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. Methods We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2–14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). Results A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. Conclusions These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention. Japanese encephalitis virus circulation has been demonstrated in urban areas of Indonesia, Malaysia, the Philippines, and Vietnam. Serological data indicate that up to 5% of children are infected annually.
AbstractList Japanese encephalitis virus circulation has been demonstrated in urban areas of Indonesia, Malaysia, the Philippines, and Vietnam. Serological data indicate that up to 5% of children are infected annually.
Abstract Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. Methods We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2–14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). Results A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. Conclusions These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention. Japanese encephalitis virus circulation has been demonstrated in urban areas of Indonesia, Malaysia, the Philippines, and Vietnam. Serological data indicate that up to 5% of children are infected annually.
Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting.BackgroundJapanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting.We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2-14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50).MethodsWe used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2-14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50).A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay.ResultsA total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay.These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.ConclusionsThese data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.
Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. Methods We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2–14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). Results A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. Conclusions These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.
Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2-14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.
Author Bonaparte, Matt
Prayitno, Ari
Hadinegoro, Sri Rezeki
Quang, Luong Chan
Nealon, Joshua
Taurel, Anne-Frieda
Capeding, Maria R.
Bouckenooghe, Alain
Moureau, Annick
Yoksan, Sutee
Chansinghakul, Danaya
AuthorAffiliation 5 Pasteur Institute Ho Chi Minh City, Vietnam
4 Sanofi Pasteur, Swiftwater, Pennsylvania
7 Universitas of Indonesia, Jakarta
2 Mahidol University, Nakhonpathom, Thailand
3 Sanofi Pasteur, Marcy L’Etoile, France
6 Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines
8 Sanofi Pasteur, Bangkok, Thailand
1 Sanofi Pasteur, Singapore
AuthorAffiliation_xml – name: 2 Mahidol University, Nakhonpathom, Thailand
– name: 3 Sanofi Pasteur, Marcy L’Etoile, France
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Issue 3
Keywords epidemiology
encephalitis
Japanese
seroepidemiologic studies
flavivirus
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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J. N. and A.-F. T. contributed equally to this work.
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Snippet Abstract Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or...
Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms...
Background Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but...
Japanese encephalitis virus circulation has been demonstrated in urban areas of Indonesia, Malaysia, the Philippines, and Vietnam. Serological data indicate...
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SubjectTerms Adolescent
Asia - epidemiology
Child
Child, Preschool
Children
Dengue - epidemiology
Dengue - immunology
Dengue fever
Dengue Vaccines
Dengue Virus - immunology
Encephalitis
Encephalitis Virus, Japanese - immunology
Encephalitis, Japanese - epidemiology
Encephalitis, Japanese - immunology
Epidemiology
Humans
Indonesia - epidemiology
Infections
Major and Brief Reports
Malaysia - epidemiology
Neurological complications
Neurological diseases
Neutralization Tests
Pediatrics
Philippines - epidemiology
Prevalence
Seroepidemiologic Studies
Serology
Vietnam - epidemiology
VIRUSES
Title Serological Evidence of Japanese Encephalitis Virus Circulation in Asian Children From Dengue-Endemic Countries
URI https://www.jstor.org/stable/26748935
https://www.ncbi.nlm.nih.gov/pubmed/30165664
https://www.proquest.com/docview/2447809289
https://www.proquest.com/docview/2098765004
https://pubmed.ncbi.nlm.nih.gov/PMC6325342
Volume 219
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