Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting tha...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 1; no. 1; p. 149
Main Authors Vattulainen-Collanus, Sanna, Southwood, Mark, Yang, Xu Dong, Moore, Stephen, Ghatpande, Prajakta, Morrell, Nicholas W., Lagna, Giorgio, Hata, Akiko
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2018
Nature Publishing Group
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders. Sanna Vattulainen-Collanus et al. report that mutations in the BMPR2 gene, which is associated with pulmonary arterial hypertension, result in a deficit of RAD51 and altered DNA repair and replication. They were able to rescue the RAD51-deficient phenotype by restoring BMPR2 activity in cell culture.
AbstractList The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders.Sanna Vattulainen-Collanus et al. report that mutations in the BMPR2 gene, which is associated with pulmonary arterial hypertension, result in a deficit of RAD51 and altered DNA repair and replication. They were able to rescue the RAD51-deficient phenotype by restoring BMPR2 activity in cell culture.
The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders. Sanna Vattulainen-Collanus et al. report that mutations in the BMPR2 gene, which is associated with pulmonary arterial hypertension, result in a deficit of RAD51 and altered DNA repair and replication. They were able to rescue the RAD51-deficient phenotype by restoring BMPR2 activity in cell culture.
Abstract The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders.
The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders.
ArticleNumber 149
Author Moore, Stephen
Hata, Akiko
Vattulainen-Collanus, Sanna
Yang, Xu Dong
Ghatpande, Prajakta
Morrell, Nicholas W.
Southwood, Mark
Lagna, Giorgio
Author_xml – sequence: 1
  givenname: Sanna
  surname: Vattulainen-Collanus
  fullname: Vattulainen-Collanus, Sanna
  organization: Cardiovascular Research Institute, University of California, San Francisco
– sequence: 2
  givenname: Mark
  surname: Southwood
  fullname: Southwood, Mark
  organization: Department of Pathology, Papworth Hospital
– sequence: 3
  givenname: Xu Dong
  surname: Yang
  fullname: Yang, Xu Dong
  organization: Department of Medicine, University of Cambridge, Addenbrook’s Hospital
– sequence: 4
  givenname: Stephen
  surname: Moore
  fullname: Moore, Stephen
  organization: Department of Medicine, University of Cambridge, Addenbrook’s Hospital
– sequence: 5
  givenname: Prajakta
  surname: Ghatpande
  fullname: Ghatpande, Prajakta
  organization: Cardiovascular Research Institute, University of California, San Francisco
– sequence: 6
  givenname: Nicholas W.
  orcidid: 0000-0001-5700-9792
  surname: Morrell
  fullname: Morrell, Nicholas W.
  organization: Department of Medicine, University of Cambridge, Addenbrook’s Hospital
– sequence: 7
  givenname: Giorgio
  surname: Lagna
  fullname: Lagna, Giorgio
  organization: Cardiovascular Research Institute, University of California, San Francisco
– sequence: 8
  givenname: Akiko
  orcidid: 0000-0003-3784-1738
  surname: Hata
  fullname: Hata, Akiko
  email: akiko.hata@ucsf.edu
  organization: Cardiovascular Research Institute, University of California, San Francisco, Department of Biochemistry and Biophysics, University of California, San Francisco
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30272025$$D View this record in MEDLINE/PubMed
BookMark eNp1kU9rFjEQxoO02PraD-BFAl68bM2fze7mItSqVSgURM8hm53sm7KbvE2yhR795mZ521qFHkKGmSe_mcnzCh344AGhN5ScUsK7D6lmhPCK0K4cwSr6Ah0zLmXFm5odPImP0ElK14QQKqVseP0SHXHCWkaYOEa_PxUqnkPcbcMIHrIzeBdDBudxcqPXk_MjdglHuFlchAHbEPGPs8-CVjMMTueSmrXzGbz2BnCwuHDCDHjNjdHluxLhW53MMumIwQ8hb2FyesIGpim9RodWTwlO7u8N-vX1y8_zb9Xl1cX387PLytQtyZWQEkAbqoUBBi2TA4W6sV1nNKO9bggQ0QFnHDoyAG160xMma9sTawVYwjfo4567W_oyuQGfo57ULrpZxzsVtFP_VrzbqjHcqoYKwWlbAO_vATHcLJCyml1aV9AewpIUo8WGltKaFum7_6TXYYnlM4uKd7KRkhUnNojuVSaGlCLYx2EoUavHau-xKh6r1WO1kt8-3eLxxYOjRcD2glRKfoT4t_Xz1D930rZ7
CitedBy_id crossref_primary_10_1161_CIRCRESAHA_122_321554
crossref_primary_10_3390_ijms22031179
crossref_primary_10_1371_journal_pone_0302932
crossref_primary_10_3390_genes11101224
crossref_primary_10_3390_ijms24087472
crossref_primary_10_1111_bph_15285
crossref_primary_10_1093_cvr_cvaa350
crossref_primary_10_3390_ijms21093305
crossref_primary_10_1126_scitranslmed_aaw4974
crossref_primary_10_1038_s44161_024_00495_z
crossref_primary_10_1038_s41467_023_43039_y
crossref_primary_10_1152_ajplung_00476_2019
crossref_primary_10_3389_fonc_2021_772305
Cites_doi 10.1164/rccm.201607-1515PP
10.1371/journal.pone.0062721
10.1161/01.RES.0000200180.01710.e6
10.1136/jmg.40.12.865
10.1074/jbc.M114.576488
10.1016/j.bmcl.2008.06.052
10.1007/s10741-017-9612-9
10.1038/nm.3877
10.1128/MCB.24.19.8504-8518.2004
10.1186/s12877-016-0379-y
10.1016/j.freeradbiomed.2008.07.018
10.3892/ijmm.2015.2060
10.1096/fj.00-0343com
10.1038/nature02006
10.4161/cc.9.3.10556
10.3390/ijms17060990
10.1165/rcmb.2013-0349OC
10.1098/rsob.160225
10.1164/rccm.201408-1509OC
10.1074/jbc.M109.099846
10.1002/humu.20285
10.1016/j.molcel.2012.07.029
10.1016/j.jacc.2013.10.035
10.1074/jbc.274.28.19838
10.1038/cddis.2016.105
10.4103/2045-8932.114758
10.1164/rccm.201412-2148OC
10.1172/jci.insight.90427
10.1016/j.ajhg.2013.07.004
10.1093/mutage/geh025
10.1016/j.cell.2015.08.034
10.1038/ncomms14079
10.1164/ajrccm.158.6.9805002
10.1038/s41467-018-03672-4
10.1161/01.RES.0000237021.65103.24
10.1016/j.cell.2017.01.002
10.1016/j.febslet.2012.04.030
10.1073/pnas.0605080104
10.1038/nature14580
10.1161/01.CIR.0000012754.72951.3D
10.1158/0008-5472.CAN-05-2156
10.1177/0271678X17702668
10.1038/nature07086
10.1161/01.RES.88.1.e2
10.1038/nature22046
10.1038/srep37421
10.1126/scisignal.aaf6060
10.1007/s00018-017-2510-4
10.1016/j.cmet.2015.03.010
10.1158/0008-5472.CAN-12-0103
10.1152/ajpcell.00149.2015
10.1378/chest.15-0300
10.1172/JCI1910
10.1101/cshperspect.a031989
10.1007/s00018-017-2702-y
10.1164/rccm.201411-2128OC
10.1164/rccm.201310-1749OC
10.1164/rccm.201003-0491OC
10.1038/nrcardio.2015.156
10.1093/nar/gks270
10.1084/jem.20101812
10.1002/jcb.24730
10.1164/rccm.201708-1751OC
10.4103/2045-8932.78107
10.1164/rccm.200908-1284OC
10.1016/j.molcel.2010.01.021
10.1513/AnnalsATS.201312-426LE
10.1002/ajmg.a.32468
10.1038/emboj.2008.15
10.1161/CIRCULATIONAHA.113.006167
10.1038/nature24060
10.1203/pdr.0b013e3180332cba
10.1161/CIRCULATIONAHA.106.652859
ContentType Journal Article
Copyright The Author(s) 2018
The Author(s) 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2018
– notice: The Author(s) 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
NPM
AAYXX
CITATION
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s42003-018-0152-1
DatabaseName Springer Nature OA Free Journals
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
ProQuest Central Student
SciTech Premium Collection
ProQuest Biological Science Collection
Science Database
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Science Journals (Alumni Edition)
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Central Essentials
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database


CrossRef
PubMed
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2399-3642
EndPage 149
ExternalDocumentID 10_1038_s42003_018_0152_1
30272025
Genre Journal Article
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
  grantid: HL132058
  funderid: https://doi.org/10.13039/100000050
– fundername: Medical Research Council
  grantid: MR/K020919/1
– fundername: NHLBI NIH HHS
  grantid: R01 HL132058
– fundername: British Heart Foundation
  grantid: RG/13/4/30107
– fundername: ;
  grantid: HL132058
GroupedDBID 0R~
53G
88I
ABDBF
ABUWG
ACGFS
ADBBV
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
C6C
CCPQU
DWQXO
EBS
GNUQQ
GROUPED_DOAJ
H13
HCIFZ
HYE
M2P
M7P
M~E
NAO
O9-
OK1
PGMZT
PIMPY
RNT
RPM
AAJSJ
ACSMW
AJTQC
EBLON
EJD
NPM
SNYQT
AAYXX
CITATION
3V.
7XB
8FE
8FH
8FK
LK8
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c470t-599eeac1a5ce2e729d1e46f88ca21ba60e058e323e80de16bcb0294fb0ff5ef03
IEDL.DBID RPM
ISSN 2399-3642
IngestDate Tue Sep 17 21:16:20 EDT 2024
Fri Oct 25 10:15:03 EDT 2024
Thu Oct 10 15:21:35 EDT 2024
Thu Sep 26 16:09:40 EDT 2024
Sat Sep 28 08:29:02 EDT 2024
Fri Oct 11 20:48:34 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c470t-599eeac1a5ce2e729d1e46f88ca21ba60e058e323e80de16bcb0294fb0ff5ef03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-3784-1738
0000-0001-5700-9792
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155317/
PMID 30272025
PQID 2389699296
PQPubID 4669726
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6155317
proquest_miscellaneous_2115271141
proquest_journals_2389699296
crossref_primary_10_1038_s42003_018_0152_1
pubmed_primary_30272025
springer_journals_10_1038_s42003_018_0152_1
PublicationCentury 2000
PublicationDate 2018-01-01
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Communications biology
PublicationTitleAbbrev Commun Biol
PublicationTitleAlternate Commun Biol
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Panieri, Santoro (CR57) 2016; 7
Truong (CR17) 2014; 289
Sage, Gildemeister, Knight (CR61) 2010; 285
Kim, Hata, Kang (CR34) 2014; 115
Wu, Chang, Mitsialis, Kourembanas (CR53) 2006; 99
Girerd (CR72) 2010; 181
Anand, Beach, Li, Haber (CR19) 2017; 544
Zhao (CR25) 2017; 550
Derynck, Zhang (CR1) 2003; 425
Tubbs, Nussenzweig (CR15) 2017; 168
Farber (CR5) 2015; 148
Courboulin (CR52) 2011; 208
Cheng, Chen (CR27) 2010; 9
Deanfield, Halcox, Rabelink (CR11) 2007; 115
Hong (CR50) 2016; 6
Garg (CR10) 2017; 22
Zhang (CR48) 2018; 38
Bonnet (CR74) 2017; 195
Hollnagel, Oehlmann, Heymer, Ruther, Nordheim (CR32) 1999; 274
Krejci, Altmannova, Spirek, Zhao (CR22) 2012; 40
Chapman, Taylor, Boulton (CR18) 2012; 47
Kashima (CR37) 2016; 9
Petermann, Orta, Issaeva, Schultz, Helleday (CR20) 2010; 37
Boucherat (CR62) 2018
Goumans, Zwijsen, Ten Dijke, Bailly (CR41) 2018; 10
De Bont, van Larebeke (CR12) 2004; 19
Long (CR30) 2015; 21
Hakem (CR21) 2008; 27
Yeager, Halley, Golpon, Voelkel, Tuder (CR13) 2001; 88
Tuder, Radisavljevic, Shroyer, Polak, Voelkel (CR68) 1998; 158
Cai, Pardali, Sanchez-Duffhues, ten Dijke (CR2) 2012; 586
Wang, Huang, Calses, Kemp, Taniguchi (CR35) 2012; 72
Bindra (CR60) 2004; 24
Lee (CR67) 1998; 101
Sessa, Hata (CR45) 2013; 3
Graf (CR71) 2018; 9
Rossi (CR47) 2015; 524
Takahashi (CR54) 2007; 61
Machado (CR3) 2006; 27
Hurst (CR39) 2017; 8
Cuny (CR31) 2008; 18
Chen (CR8) 2017; 2
Meloche (CR51) 2015; 309
Teichert-Kuliszewska (CR69) 2006; 98
Soubrier (CR6) 2013; 62
Rowe, Degtyareva, Doetsch (CR58) 2008; 45
Lane (CR59) 2011; 1
Harrison (CR73) 2003; 40
Orriols, Gomez-Puerto, Ten Dijke (CR42) 2017; 74
Dahal, Dubey, Raghavan (CR63) 2018; 75
Wooderchak-Donahue (CR70) 2013; 93
Davis, Hilyard, Lagna, Hata (CR36) 2008; 454
Xu (CR55) 2007; 104
Aldred (CR14) 2010; 182
Sanvitale (CR33) 2013; 8
Morrell (CR43) 2016; 13
Cousineau, Abaji, Belmaaza (CR16) 2005; 65
Federici (CR66) 2015; 192
Budzinska (CR49) 2016; 16
Soon (CR56) 2015; 192
Rigelsky (CR4) 2008; 146A
Taraseviciene-Stewart (CR38) 2001; 15
Wallace (CR46) 2015; 191
Moureau, Luessing, Harte, Voisin, Lowndes (CR28) 2016; 6
Meloche (CR40) 2014; 129
Haber (CR65) 2015; 162
Botros, Van Nieuw Amerongen, Vonk Noordegraaf, Bogaard (CR9) 2014; 11
Hata, Kang (CR44) 2015; 35
Cardiff, Miller, Munn (CR75) 2014; 2014
Atkinson (CR7) 2002; 105
de Jesus Perez (CR24) 2014; 189
Ranchoux (CR64) 2016; 17
Diebold (CR29) 2015; 21
Pu, Wang, Klaunig (CR26) 2015; 65
Li (CR23) 2014; 50
R Anand (152_CR19) 2017; 544
CM Rigelsky (152_CR4) 2008; 146A
LN Truong (152_CR17) 2014; 289
L Krejci (152_CR22) 2012; 40
S Bonnet (152_CR74) 2017; 195
R Sessa (152_CR45) 2013; 3
H Zhang (152_CR48) 2018; 38
SD Lee (152_CR67) 1998; 101
CE Sanvitale (152_CR33) 2013; 8
S Dahal (152_CR63) 2018; 75
RE Harrison (152_CR73) 2003; 40
KL Lane (152_CR59) 2011; 1
I Cousineau (152_CR16) 2005; 65
MA Aldred (152_CR14) 2010; 182
R Kashima (152_CR37) 2016; 9
A Rossi (152_CR47) 2015; 524
L Taraseviciene-Stewart (152_CR38) 2001; 15
F Soubrier (152_CR6) 2013; 62
J Meloche (152_CR40) 2014; 129
JE Deanfield (152_CR11) 2007; 115
LA Hurst (152_CR39) 2017; 8
A Courboulin (152_CR52) 2011; 208
WL Wooderchak-Donahue (152_CR70) 2013; 93
Q Cheng (152_CR27) 2010; 9
E Panieri (152_CR57) 2016; 7
K Takahashi (152_CR54) 2007; 61
E Petermann (152_CR20) 2010; 37
S Kim (152_CR34) 2014; 115
JE Haber (152_CR65) 2015; 162
RM Tuder (152_CR68) 1998; 158
M Budzinska (152_CR49) 2016; 16
RD Cardiff (152_CR75) 2014; 2014
E Wallace (152_CR46) 2015; 191
K Teichert-Kuliszewska (152_CR69) 2006; 98
PI Chen (152_CR8) 2017; 2
J Meloche (152_CR51) 2015; 309
E Soon (152_CR56) 2015; 192
J Cai (152_CR2) 2012; 586
W Zhao (152_CR25) 2017; 550
B Girerd (152_CR72) 2010; 181
L Garg (152_CR10) 2017; 22
Y Hong (152_CR50) 2016; 6
S Moureau (152_CR28) 2016; 6
GD Cuny (152_CR31) 2008; 18
S Graf (152_CR71) 2018; 9
L Botros (152_CR9) 2014; 11
JR Chapman (152_CR18) 2012; 47
RD Machado (152_CR3) 2006; 27
A Hollnagel (152_CR32) 1999; 274
JM Sage (152_CR61) 2010; 285
LA Rowe (152_CR58) 2008; 45
NW Morrell (152_CR43) 2016; 13
B Ranchoux (152_CR64) 2016; 17
HW Farber (152_CR5) 2015; 148
L Long (152_CR30) 2015; 21
VA de Jesus Perez (152_CR24) 2014; 189
C Atkinson (152_CR7) 2002; 105
M Orriols (152_CR42) 2017; 74
RS Bindra (152_CR60) 2004; 24
W Xu (152_CR55) 2007; 104
BN Davis (152_CR36) 2008; 454
R De Bont (152_CR12) 2004; 19
I Diebold (152_CR29) 2015; 21
R Derynck (152_CR1) 2003; 425
ME Yeager (152_CR13) 2001; 88
X Wu (152_CR53) 2006; 99
A Tubbs (152_CR15) 2017; 168
R Hakem (152_CR21) 2008; 27
X Pu (152_CR26) 2015; 65
A Hata (152_CR44) 2015; 35
C Federici (152_CR66) 2015; 192
M Li (152_CR23) 2014; 50
MJ Goumans (152_CR41) 2018; 10
Y Wang (152_CR35) 2012; 72
O Boucherat (152_CR62) 2018
References_xml – volume: 195
  start-page: 583
  year: 2017
  end-page: 595
  ident: CR74
  article-title: Translating research into improved patient care in pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201607-1515PP
  contributor:
    fullname: Bonnet
– volume: 8
  start-page: e62721
  year: 2013
  ident: CR33
  article-title: A new class of small molecule inhibitor of BMP signaling
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0062721
  contributor:
    fullname: Sanvitale
– volume: 98
  start-page: 209
  year: 2006
  end-page: 217
  ident: CR69
  article-title: Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000200180.01710.e6
  contributor:
    fullname: Teichert-Kuliszewska
– volume: 40
  start-page: 865
  year: 2003
  end-page: 871
  ident: CR73
  article-title: Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.40.12.865
  contributor:
    fullname: Harrison
– volume: 289
  start-page: 28910
  year: 2014
  end-page: 28923
  ident: CR17
  article-title: Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.576488
  contributor:
    fullname: Truong
– volume: 18
  start-page: 4388
  year: 2008
  end-page: 4392
  ident: CR31
  article-title: Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2008.06.052
  contributor:
    fullname: Cuny
– volume: 22
  start-page: 289
  year: 2017
  end-page: 297
  ident: CR10
  article-title: Drug-induced pulmonary arterial hypertension: a review
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-017-9612-9
  contributor:
    fullname: Garg
– volume: 21
  start-page: 777
  year: 2015
  end-page: 785
  ident: CR30
  article-title: Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
  publication-title: Nat. Med.
  doi: 10.1038/nm.3877
  contributor:
    fullname: Long
– volume: 24
  start-page: 8504
  year: 2004
  end-page: 8518
  ident: CR60
  article-title: Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.19.8504-8518.2004
  contributor:
    fullname: Bindra
– volume: 16
  start-page: 200
  year: 2016
  ident: CR49
  article-title: miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans
  publication-title: BMC Geriatr.
  doi: 10.1186/s12877-016-0379-y
  contributor:
    fullname: Budzinska
– volume: 45
  start-page: 1167
  year: 2008
  end-page: 1177
  ident: CR58
  article-title: DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2008.07.018
  contributor:
    fullname: Doetsch
– volume: 35
  start-page: 563
  year: 2015
  end-page: 568
  ident: CR44
  article-title: Functions of the bone morphogenetic protein signaling pathway through microRNAs (review)
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2015.2060
  contributor:
    fullname: Kang
– volume: 15
  start-page: 427
  year: 2001
  end-page: 438
  ident: CR38
  article-title: Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
  publication-title: FASEB J.
  doi: 10.1096/fj.00-0343com
  contributor:
    fullname: Taraseviciene-Stewart
– volume: 425
  start-page: 577
  year: 2003
  end-page: 584
  ident: CR1
  article-title: Smad-dependent and Smad-independent pathways in TGF-beta family signalling
  publication-title: Nature
  doi: 10.1038/nature02006
  contributor:
    fullname: Zhang
– volume: 9
  start-page: 472
  year: 2010
  end-page: 478
  ident: CR27
  article-title: Mechanism of p53 stabilization by ATM after DNA damage
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.3.10556
  contributor:
    fullname: Chen
– volume: 17
  start-page: pii: E990
  year: 2016
  ident: CR64
  article-title: DNA damage and pulmonary hypertension
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms17060990
  contributor:
    fullname: Ranchoux
– volume: 50
  start-page: 1118
  year: 2014
  end-page: 1128
  ident: CR23
  article-title: Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2013-0349OC
  contributor:
    fullname: Li
– volume: 2014
  start-page: 655
  year: 2014
  end-page: 658
  ident: CR75
  article-title: Manual hematoxylin and eosin staining of mouse tissue sections
  publication-title: Cold Spring Harb. Protoc.
  contributor:
    fullname: Munn
– volume: 6
  start-page: pii: 160225
  year: 2016
  ident: CR28
  article-title: A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
  publication-title: Open Biol
  doi: 10.1098/rsob.160225
  contributor:
    fullname: Lowndes
– volume: 192
  start-page: 859
  year: 2015
  end-page: 872
  ident: CR56
  article-title: Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201408-1509OC
  contributor:
    fullname: Soon
– volume: 285
  start-page: 18984
  year: 2010
  end-page: 18990
  ident: CR61
  article-title: Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.099846
  contributor:
    fullname: Knight
– volume: 27
  start-page: 121
  year: 2006
  end-page: 132
  ident: CR3
  article-title: Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20285
  contributor:
    fullname: Machado
– volume: 47
  start-page: 497
  year: 2012
  end-page: 510
  ident: CR18
  article-title: Playing the end game: DNA double-strand break repair pathway choice
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.07.029
  contributor:
    fullname: Boulton
– volume: 62
  start-page: D13
  year: 2013
  end-page: D21
  ident: CR6
  article-title: Genetics and genomics of pulmonary arterial hypertension
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2013.10.035
  contributor:
    fullname: Soubrier
– volume: 274
  start-page: 19838
  year: 1999
  end-page: 19845
  ident: CR32
  article-title: Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.28.19838
  contributor:
    fullname: Nordheim
– volume: 7
  year: 2016
  ident: CR57
  article-title: ROS homeostasis and metabolism: a dangerous liason in cancer cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2016.105
  contributor:
    fullname: Santoro
– volume: 115
  start-page: 1285
  year: 2007
  end-page: 1295
  ident: CR11
  article-title: Endothelial function and dysfunction: testing and clinical relevance
  publication-title: Circulation
  contributor:
    fullname: Rabelink
– volume: 3
  start-page: 315
  year: 2013
  end-page: 328
  ident: CR45
  article-title: Role of microRNAs in lung development and pulmonary diseases
  publication-title: Pulm. Circ.
  doi: 10.4103/2045-8932.114758
  contributor:
    fullname: Hata
– volume: 191
  start-page: 1432
  year: 2015
  end-page: 1442
  ident: CR46
  article-title: A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201412-2148OC
  contributor:
    fullname: Wallace
– volume: 2
  start-page: e90427
  year: 2017
  ident: CR8
  article-title: Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.90427
  contributor:
    fullname: Chen
– volume: 93
  start-page: 530
  year: 2013
  end-page: 537
  ident: CR70
  article-title: BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2013.07.004
  contributor:
    fullname: Wooderchak-Donahue
– volume: 19
  start-page: 169
  year: 2004
  end-page: 185
  ident: CR12
  article-title: Endogenous DNA damage in humans: a review of quantitative data
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geh025
  contributor:
    fullname: van Larebeke
– volume: 162
  start-page: 1183
  year: 2015
  end-page: 1185
  ident: CR65
  article-title: Deciphering the DNA damage response
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.034
  contributor:
    fullname: Haber
– volume: 8
  year: 2017
  ident: CR39
  article-title: TNFalpha drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14079
  contributor:
    fullname: Hurst
– volume: 158
  start-page: 1999
  year: 1998
  end-page: 2001
  ident: CR68
  article-title: Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.158.6.9805002
  contributor:
    fullname: Voelkel
– volume: 9
  year: 2018
  ident: CR71
  article-title: Identification of rare sequence variation underlying heritable pulmonary arterial hypertension
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03672-4
  contributor:
    fullname: Graf
– volume: 99
  start-page: 240
  year: 2006
  end-page: 247
  ident: CR53
  article-title: Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000237021.65103.24
  contributor:
    fullname: Kourembanas
– volume: 168
  start-page: 644
  year: 2017
  end-page: 656
  ident: CR15
  article-title: Endogenous DNA damage as a source of genomic instability in cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2017.01.002
  contributor:
    fullname: Nussenzweig
– volume: 586
  start-page: 1993
  year: 2012
  end-page: 2002
  ident: CR2
  article-title: BMP signaling in vascular diseases
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2012.04.030
  contributor:
    fullname: ten Dijke
– volume: 65
  start-page: 3 12 11
  year: 2015
  end-page: 11
  ident: CR26
  article-title: Alkaline comet assay for assessing DNA damage in individual cells
  publication-title: Curr. Protoc. Toxicol.
  contributor:
    fullname: Klaunig
– volume: 104
  start-page: 1342
  year: 2007
  end-page: 1347
  ident: CR55
  article-title: Alterations of cellular bioenergetics in pulmonary artery endothelial cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605080104
  contributor:
    fullname: Xu
– volume: 524
  start-page: 230
  year: 2015
  end-page: 233
  ident: CR47
  article-title: Genetic compensation induced by deleterious mutations but not gene knockdowns
  publication-title: Nature
  doi: 10.1038/nature14580
  contributor:
    fullname: Rossi
– volume: 105
  start-page: 1672
  year: 2002
  end-page: 1678
  ident: CR7
  article-title: Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000012754.72951.3D
  contributor:
    fullname: Atkinson
– volume: 65
  start-page: 11384
  year: 2005
  end-page: 11391
  ident: CR16
  article-title: BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-2156
  contributor:
    fullname: Belmaaza
– volume: 38
  start-page: 809
  year: 2018
  end-page: 822
  ident: CR48
  article-title: ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1177/0271678X17702668
  contributor:
    fullname: Zhang
– volume: 454
  start-page: 56
  year: 2008
  end-page: 61
  ident: CR36
  article-title: SMAD proteins control DROSHA-mediated microRNA maturation
  publication-title: Nature
  doi: 10.1038/nature07086
  contributor:
    fullname: Hata
– volume: 88
  start-page: E2
  year: 2001
  end-page: E11
  ident: CR13
  article-title: Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.88.1.e2
  contributor:
    fullname: Tuder
– volume: 544
  start-page: 377
  year: 2017
  end-page: 380
  ident: CR19
  article-title: Rad51-mediated double-strand break repair and mismatch correction of divergent substrates
  publication-title: Nature
  doi: 10.1038/nature22046
  contributor:
    fullname: Haber
– volume: 6
  year: 2016
  ident: CR50
  article-title: miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
  publication-title: Sci. Rep.
  doi: 10.1038/srep37421
  contributor:
    fullname: Hong
– volume: 9
  start-page: ra58
  year: 2016
  ident: CR37
  article-title: Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaf6060
  contributor:
    fullname: Kashima
– volume: 74
  start-page: 2979
  year: 2017
  end-page: 2995
  ident: CR42
  article-title: BMP type II receptor as a therapeutic target in pulmonary arterial hypertension
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-017-2510-4
  contributor:
    fullname: Ten Dijke
– volume: 21
  start-page: 596
  year: 2015
  end-page: 608
  ident: CR29
  article-title: BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.03.010
  contributor:
    fullname: Diebold
– volume: 72
  start-page: 4037
  year: 2012
  end-page: 4046
  ident: CR35
  article-title: MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-0103
  contributor:
    fullname: Taniguchi
– volume: 309
  start-page: C363
  year: 2015
  end-page: C372
  ident: CR51
  article-title: miR-223 reverses experimental pulmonary arterial hypertension
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00149.2015
  contributor:
    fullname: Meloche
– volume: 148
  start-page: 1043
  year: 2015
  end-page: 1054
  ident: CR5
  article-title: Five-Year outcomes of patients enrolled in the REVEAL Registry
  publication-title: Chest
  doi: 10.1378/chest.15-0300
  contributor:
    fullname: Farber
– volume: 101
  start-page: 927
  year: 1998
  end-page: 934
  ident: CR67
  article-title: Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI1910
  contributor:
    fullname: Lee
– volume: 10
  start-page: pii: a031989
  year: 2018
  ident: CR41
  article-title: Bone morphogenetic proteins in vascular homeostasis and disease
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a031989
  contributor:
    fullname: Bailly
– volume: 75
  start-page: 1641
  year: 2018
  end-page: 1655
  ident: CR63
  article-title: Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-017-2702-y
  contributor:
    fullname: Raghavan
– volume: 192
  start-page: 219
  year: 2015
  end-page: 228
  ident: CR66
  article-title: Increased mutagen sensitivity and DNA damage in pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201411-2128OC
  contributor:
    fullname: Federici
– volume: 189
  start-page: 1260
  year: 2014
  end-page: 1272
  ident: CR24
  article-title: Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201310-1749OC
  contributor:
    fullname: de Jesus Perez
– volume: 182
  start-page: 1153
  year: 2010
  end-page: 1160
  ident: CR14
  article-title: Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201003-0491OC
  contributor:
    fullname: Aldred
– volume: 13
  start-page: 106
  year: 2016
  end-page: 120
  ident: CR43
  article-title: Targeting BMP signalling in cardiovascular disease and anaemia
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2015.156
  contributor:
    fullname: Morrell
– volume: 40
  start-page: 5795
  year: 2012
  end-page: 5818
  ident: CR22
  article-title: Homologous recombination and its regulation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks270
  contributor:
    fullname: Zhao
– volume: 208
  start-page: 535
  year: 2011
  end-page: 548
  ident: CR52
  article-title: Role for miR-204 in human pulmonary arterial hypertension
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20101812
  contributor:
    fullname: Courboulin
– volume: 115
  start-page: 889
  year: 2014
  end-page: 895
  ident: CR34
  article-title: Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.24730
  contributor:
    fullname: Kang
– year: 2018
  ident: CR62
  article-title: Mitochondrial HSP90 accumulation promotes vascular remodeling in pulmonary arterial hypertension
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201708-1751OC
  contributor:
    fullname: Boucherat
– volume: 1
  start-page: 72
  year: 2011
  end-page: 83
  ident: CR59
  article-title: Oxidative injury is a common consequence of BMPR2 mutations
  publication-title: Pulm. Circ.
  doi: 10.4103/2045-8932.78107
  contributor:
    fullname: Lane
– volume: 181
  start-page: 851
  year: 2010
  end-page: 861
  ident: CR72
  article-title: Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200908-1284OC
  contributor:
    fullname: Girerd
– volume: 37
  start-page: 492
  year: 2010
  end-page: 502
  ident: CR20
  article-title: Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.01.021
  contributor:
    fullname: Helleday
– volume: 11
  start-page: 468
  year: 2014
  end-page: 470
  ident: CR9
  article-title: Recovery from mitomycin-induced pulmonary arterial hypertension
  publication-title: Ann. Am. Thorac. Soc.
  doi: 10.1513/AnnalsATS.201312-426LE
  contributor:
    fullname: Bogaard
– volume: 146A
  start-page: 2551
  year: 2008
  end-page: 2556
  ident: CR4
  article-title: BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.32468
  contributor:
    fullname: Rigelsky
– volume: 27
  start-page: 589
  year: 2008
  end-page: 605
  ident: CR21
  article-title: DNA-damage repair; the good, the bad, and the ugly
  publication-title: EMBO J.
  doi: 10.1038/emboj.2008.15
  contributor:
    fullname: Hakem
– volume: 129
  start-page: 786
  year: 2014
  end-page: 797
  ident: CR40
  article-title: Role for DNA damage signaling in pulmonary arterial hypertension
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.006167
  contributor:
    fullname: Meloche
– volume: 550
  start-page: 360
  year: 2017
  end-page: 365
  ident: CR25
  article-title: BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing
  publication-title: Nature
  doi: 10.1038/nature24060
  contributor:
    fullname: Zhao
– volume: 61
  start-page: 392
  year: 2007
  end-page: 397
  ident: CR54
  article-title: Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell
  publication-title: Pediatr. Res.
  doi: 10.1203/pdr.0b013e3180332cba
  contributor:
    fullname: Takahashi
– volume: 2014
  start-page: 655
  year: 2014
  ident: 152_CR75
  publication-title: Cold Spring Harb. Protoc.
  contributor:
    fullname: RD Cardiff
– volume: 37
  start-page: 492
  year: 2010
  ident: 152_CR20
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.01.021
  contributor:
    fullname: E Petermann
– volume: 195
  start-page: 583
  year: 2017
  ident: 152_CR74
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201607-1515PP
  contributor:
    fullname: S Bonnet
– volume: 189
  start-page: 1260
  year: 2014
  ident: 152_CR24
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201310-1749OC
  contributor:
    fullname: VA de Jesus Perez
– volume: 181
  start-page: 851
  year: 2010
  ident: 152_CR72
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200908-1284OC
  contributor:
    fullname: B Girerd
– volume: 35
  start-page: 563
  year: 2015
  ident: 152_CR44
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2015.2060
  contributor:
    fullname: A Hata
– volume: 1
  start-page: 72
  year: 2011
  ident: 152_CR59
  publication-title: Pulm. Circ.
  doi: 10.4103/2045-8932.78107
  contributor:
    fullname: KL Lane
– volume: 454
  start-page: 56
  year: 2008
  ident: 152_CR36
  publication-title: Nature
  doi: 10.1038/nature07086
  contributor:
    fullname: BN Davis
– volume: 192
  start-page: 859
  year: 2015
  ident: 152_CR56
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201408-1509OC
  contributor:
    fullname: E Soon
– volume: 3
  start-page: 315
  year: 2013
  ident: 152_CR45
  publication-title: Pulm. Circ.
  doi: 10.4103/2045-8932.114758
  contributor:
    fullname: R Sessa
– volume: 425
  start-page: 577
  year: 2003
  ident: 152_CR1
  publication-title: Nature
  doi: 10.1038/nature02006
  contributor:
    fullname: R Derynck
– volume: 47
  start-page: 497
  year: 2012
  ident: 152_CR18
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.07.029
  contributor:
    fullname: JR Chapman
– volume: 40
  start-page: 5795
  year: 2012
  ident: 152_CR22
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks270
  contributor:
    fullname: L Krejci
– year: 2018
  ident: 152_CR62
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201708-1751OC
  contributor:
    fullname: O Boucherat
– volume: 38
  start-page: 809
  year: 2018
  ident: 152_CR48
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1177/0271678X17702668
  contributor:
    fullname: H Zhang
– volume: 586
  start-page: 1993
  year: 2012
  ident: 152_CR2
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2012.04.030
  contributor:
    fullname: J Cai
– volume: 146A
  start-page: 2551
  year: 2008
  ident: 152_CR4
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.32468
  contributor:
    fullname: CM Rigelsky
– volume: 285
  start-page: 18984
  year: 2010
  ident: 152_CR61
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.099846
  contributor:
    fullname: JM Sage
– volume: 115
  start-page: 1285
  year: 2007
  ident: 152_CR11
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.652859
  contributor:
    fullname: JE Deanfield
– volume: 24
  start-page: 8504
  year: 2004
  ident: 152_CR60
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.19.8504-8518.2004
  contributor:
    fullname: RS Bindra
– volume: 93
  start-page: 530
  year: 2013
  ident: 152_CR70
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2013.07.004
  contributor:
    fullname: WL Wooderchak-Donahue
– volume: 289
  start-page: 28910
  year: 2014
  ident: 152_CR17
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.576488
  contributor:
    fullname: LN Truong
– volume: 9
  year: 2018
  ident: 152_CR71
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03672-4
  contributor:
    fullname: S Graf
– volume: 22
  start-page: 289
  year: 2017
  ident: 152_CR10
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-017-9612-9
  contributor:
    fullname: L Garg
– volume: 168
  start-page: 644
  year: 2017
  ident: 152_CR15
  publication-title: Cell
  doi: 10.1016/j.cell.2017.01.002
  contributor:
    fullname: A Tubbs
– volume: 129
  start-page: 786
  year: 2014
  ident: 152_CR40
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.006167
  contributor:
    fullname: J Meloche
– volume: 6
  start-page: pii: 160225
  year: 2016
  ident: 152_CR28
  publication-title: Open Biol
  doi: 10.1098/rsob.160225
  contributor:
    fullname: S Moureau
– volume: 16
  start-page: 200
  year: 2016
  ident: 152_CR49
  publication-title: BMC Geriatr.
  doi: 10.1186/s12877-016-0379-y
  contributor:
    fullname: M Budzinska
– volume: 45
  start-page: 1167
  year: 2008
  ident: 152_CR58
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2008.07.018
  contributor:
    fullname: LA Rowe
– volume: 544
  start-page: 377
  year: 2017
  ident: 152_CR19
  publication-title: Nature
  doi: 10.1038/nature22046
  contributor:
    fullname: R Anand
– volume: 21
  start-page: 596
  year: 2015
  ident: 152_CR29
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.03.010
  contributor:
    fullname: I Diebold
– volume: 115
  start-page: 889
  year: 2014
  ident: 152_CR34
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.24730
  contributor:
    fullname: S Kim
– volume: 6
  year: 2016
  ident: 152_CR50
  publication-title: Sci. Rep.
  doi: 10.1038/srep37421
  contributor:
    fullname: Y Hong
– volume: 62
  start-page: D13
  year: 2013
  ident: 152_CR6
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2013.10.035
  contributor:
    fullname: F Soubrier
– volume: 8
  year: 2017
  ident: 152_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14079
  contributor:
    fullname: LA Hurst
– volume: 274
  start-page: 19838
  year: 1999
  ident: 152_CR32
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.28.19838
  contributor:
    fullname: A Hollnagel
– volume: 8
  start-page: e62721
  year: 2013
  ident: 152_CR33
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0062721
  contributor:
    fullname: CE Sanvitale
– volume: 191
  start-page: 1432
  year: 2015
  ident: 152_CR46
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201412-2148OC
  contributor:
    fullname: E Wallace
– volume: 17
  start-page: pii: E990
  year: 2016
  ident: 152_CR64
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms17060990
  contributor:
    fullname: B Ranchoux
– volume: 101
  start-page: 927
  year: 1998
  ident: 152_CR67
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI1910
  contributor:
    fullname: SD Lee
– volume: 27
  start-page: 589
  year: 2008
  ident: 152_CR21
  publication-title: EMBO J.
  doi: 10.1038/emboj.2008.15
  contributor:
    fullname: R Hakem
– volume: 9
  start-page: ra58
  year: 2016
  ident: 152_CR37
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaf6060
  contributor:
    fullname: R Kashima
– volume: 550
  start-page: 360
  year: 2017
  ident: 152_CR25
  publication-title: Nature
  doi: 10.1038/nature24060
  contributor:
    fullname: W Zhao
– volume: 19
  start-page: 169
  year: 2004
  ident: 152_CR12
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geh025
  contributor:
    fullname: R De Bont
– volume: 182
  start-page: 1153
  year: 2010
  ident: 152_CR14
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201003-0491OC
  contributor:
    fullname: MA Aldred
– volume: 61
  start-page: 392
  year: 2007
  ident: 152_CR54
  publication-title: Pediatr. Res.
  doi: 10.1203/pdr.0b013e3180332cba
  contributor:
    fullname: K Takahashi
– volume: 105
  start-page: 1672
  year: 2002
  ident: 152_CR7
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000012754.72951.3D
  contributor:
    fullname: C Atkinson
– volume: 18
  start-page: 4388
  year: 2008
  ident: 152_CR31
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2008.06.052
  contributor:
    fullname: GD Cuny
– volume: 162
  start-page: 1183
  year: 2015
  ident: 152_CR65
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.034
  contributor:
    fullname: JE Haber
– volume: 11
  start-page: 468
  year: 2014
  ident: 152_CR9
  publication-title: Ann. Am. Thorac. Soc.
  doi: 10.1513/AnnalsATS.201312-426LE
  contributor:
    fullname: L Botros
– volume: 192
  start-page: 219
  year: 2015
  ident: 152_CR66
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201411-2128OC
  contributor:
    fullname: C Federici
– volume: 7
  year: 2016
  ident: 152_CR57
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2016.105
  contributor:
    fullname: E Panieri
– volume: 72
  start-page: 4037
  year: 2012
  ident: 152_CR35
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-0103
  contributor:
    fullname: Y Wang
– volume: 13
  start-page: 106
  year: 2016
  ident: 152_CR43
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2015.156
  contributor:
    fullname: NW Morrell
– volume: 9
  start-page: 472
  year: 2010
  ident: 152_CR27
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.3.10556
  contributor:
    fullname: Q Cheng
– volume: 40
  start-page: 865
  year: 2003
  ident: 152_CR73
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.40.12.865
  contributor:
    fullname: RE Harrison
– volume: 21
  start-page: 777
  year: 2015
  ident: 152_CR30
  publication-title: Nat. Med.
  doi: 10.1038/nm.3877
  contributor:
    fullname: L Long
– volume: 524
  start-page: 230
  year: 2015
  ident: 152_CR47
  publication-title: Nature
  doi: 10.1038/nature14580
  contributor:
    fullname: A Rossi
– volume: 65
  start-page: 11384
  year: 2005
  ident: 152_CR16
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-2156
  contributor:
    fullname: I Cousineau
– volume: 10
  start-page: pii: a031989
  year: 2018
  ident: 152_CR41
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a031989
  contributor:
    fullname: MJ Goumans
– volume: 104
  start-page: 1342
  year: 2007
  ident: 152_CR55
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605080104
  contributor:
    fullname: W Xu
– volume: 27
  start-page: 121
  year: 2006
  ident: 152_CR3
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20285
  contributor:
    fullname: RD Machado
– volume: 309
  start-page: C363
  year: 2015
  ident: 152_CR51
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00149.2015
  contributor:
    fullname: J Meloche
– volume: 65
  start-page: 3 12 11
  year: 2015
  ident: 152_CR26
  publication-title: Curr. Protoc. Toxicol.
  contributor:
    fullname: X Pu
– volume: 99
  start-page: 240
  year: 2006
  ident: 152_CR53
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000237021.65103.24
  contributor:
    fullname: X Wu
– volume: 98
  start-page: 209
  year: 2006
  ident: 152_CR69
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000200180.01710.e6
  contributor:
    fullname: K Teichert-Kuliszewska
– volume: 75
  start-page: 1641
  year: 2018
  ident: 152_CR63
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-017-2702-y
  contributor:
    fullname: S Dahal
– volume: 208
  start-page: 535
  year: 2011
  ident: 152_CR52
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20101812
  contributor:
    fullname: A Courboulin
– volume: 158
  start-page: 1999
  year: 1998
  ident: 152_CR68
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.158.6.9805002
  contributor:
    fullname: RM Tuder
– volume: 2
  start-page: e90427
  year: 2017
  ident: 152_CR8
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.90427
  contributor:
    fullname: PI Chen
– volume: 88
  start-page: E2
  year: 2001
  ident: 152_CR13
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.88.1.e2
  contributor:
    fullname: ME Yeager
– volume: 15
  start-page: 427
  year: 2001
  ident: 152_CR38
  publication-title: FASEB J.
  doi: 10.1096/fj.00-0343com
  contributor:
    fullname: L Taraseviciene-Stewart
– volume: 148
  start-page: 1043
  year: 2015
  ident: 152_CR5
  publication-title: Chest
  doi: 10.1378/chest.15-0300
  contributor:
    fullname: HW Farber
– volume: 50
  start-page: 1118
  year: 2014
  ident: 152_CR23
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2013-0349OC
  contributor:
    fullname: M Li
– volume: 74
  start-page: 2979
  year: 2017
  ident: 152_CR42
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-017-2510-4
  contributor:
    fullname: M Orriols
SSID ssj0001999634
Score 2.1589386
Snippet The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2)...
Abstract The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II...
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 149
SubjectTerms 13/106
13/109
13/51
13/89
38/39
38/90
631/337/1427/2566
631/80/86/2370
692/4019/592/75/593/1920
82/80
Animal models
Biology
Biomedical and Life Sciences
Blood vessels
Bone morphogenetic protein receptor type II
Bone morphogenetic proteins
Cell culture
Cell death
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
DNA repair
Endothelial cells
Genomes
Hemorrhage
Hereditary hemorrhagic telangiectasia
Homeostasis
Hypertension
Life Sciences
Mutation
Phenotypes
Pulmonary hypertension
Replication
Signal transduction
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEBbthkIvpe86j6JCTy0mkizJ8qkkaUIoNJTQQG7GskZ0IWun8ebQY_55ZvzYZRta8MFgYXs0I-mTZuYbxj7mQVoVXE08lT7VlanSQucmlbW1wYm8iH0uzPcze3qhv12ay_HArRvDKqc5sZ-oQ1vTGfk-Li2FLXAxt1-uf6dUNYq8q2MJjcdsS-FOQc3Y1uHx2Y_z9SkL4flMT-7MzO13ug_HEpJiuIxK5eaC9ABlPgyW_Mtj2i9EJ8_ZsxFB8oNB5S_YI2hesidDTck_r9jdYdsAX7TYfy0aB-Uo8p6MYd5wCtaoKP-czzt-AxQEDIEjbOXnB1-NTPs0EoSgfFERjQRxcQBvIyci1wXwgVoCYTve8SmElUMTKIvrCg2Zkxuge80uTo5_Hp2mY52FtNa5WKamKADnX1mZGhQg2g4StI3O1ZWSvrIChHGQqQycCCCtr71QhY5exGggiuwNmzUo2zvGIQt11MJ5UXhtZXQgvZFeZjKIopYxYZ-mzi6vBzqNsneDZ64cNFOiZkrSTCkTtjupoxxHVleu7SBhH1aPcUyQhFUD7S22kVSsF3d6-Iq3g_ZWXyM_rUKgl7B8Q6-rBsS3vfmkmf_qebfJhYtwK2GfJwtY_9Y_hdj-vxA77KkabBGvXTZb3tzCHsKcpX8_2vI9Ajj-rQ
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1NT9wwELUqUCUuiEILoRQZiVOrCDuxHfsI2yJUqT1UIHGL4ngsVmITtLscOPLPmUk2i7bAASmHSJ582DOJnz0zbxg7LoI0WbA18VT6VFW6Sp0qdCprY4IVhYtdLsyfv-biSv2-1tcLsmjKhVnx3-f2ZKa66CkhKeRKZykudNZpCqZiBSMzet5OIeCeq8Fv-dqVqzPPCzj5MiryP9doN-Ocb7HNBVTkp71uP7EP0Gyzj33xyIcd9njWNsAnLQ5Ui1ZAyYi8Y10YN5yiMipKNOfjGZ8CRftC4IhP-b_Tn1qmXb4IYk0-qYgvgkg3gLeRE2PrBHjPIYH4HM_4EKvKoQmUrnWLFstpv3_2mV2d_7ocXaSLggpprQoxT7VzgD9aWekaMkBYHSQoE62tq0z6yggQ2kKe5WBFAGl87UXmVPQiRg1R5F_YWoN922Mc8lBHJawXzisjowXptfQyl0G4WsaEfR8Gu7zreTPKzt-d27LXTImaKUkzpUzYwaCOcvEJzUrEEs44RG8mYUfLZjR-6mHVQHuPMpKq8uKSDm-x22tv-TRyyGaI6BJWrOh1KUDE2qstzfimI9gmXy3iqoT9GCzg-bXe7MT-u6S_so2sN008DtjafHoP3xDezP1hZ9hPVwb1eA
  priority: 102
  providerName: Springer Nature
Title Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells
URI https://link.springer.com/article/10.1038/s42003-018-0152-1
https://www.ncbi.nlm.nih.gov/pubmed/30272025
https://www.proquest.com/docview/2389699296
https://search.proquest.com/docview/2115271141
https://pubmed.ncbi.nlm.nih.gov/PMC6155317
Volume 1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEB2yKYVeSr_jNl1U6KnFWcmWZPmYbBNCISGEBnIzljyiC7EdsptDj_3nHcnrbbehl4IPBhvb0oysJ82bNwAfi0borDEu6FTaVNaqTktZqFQ4rRvDi9LHXJizc316Jb9eq-sdUGMuTCTtO7s46G7ag27xPXIrb1s3G3lis4uzeYil0bw3m8CEHPSPJXrcWAkQPpdjBDM3s6WMDCwuAm1LZWmoDhPCdbTuV9vT0QOM-ZAq-Ve8NE5DJ8_g6Ro_ssPhO5_DDnYv4PFQUfLHS_h51HfI2p56ryfXCBmKLEoxLDoWqBp1yD5niyW7w0ABxoYRaGWXh1-USGMSCQFQ1tZBRCIocSDrPQsyri2yQViCQDudsZHAyrBrQg7XDbkxC0GA5Su4Ojn-Nj9N11UWUicLvkpVWSL9fUWtHGZIWLsRKLU3xtWZsLXmyJXBPMvR8AaFts7yrJTecu8Vep6_ht2O2rYHDPPGecmN5aWVWniDwiphRS4aXjrhE_g0dnZ1O4hpVDEInptqMFJFRqqCkSqRwP5ojmo9rpYVAYxSlwTpdAIfNpdpRIQW1h3293SPCKV6aZ1Hj3gzWG_zttHsCRRbdt3cENS2t6-QE0bV7bXTJfB59IDfn_XPRrz97_e8gyfZ4LF07MPu6u4e3xP-WdkpPDo6Pr-4nMJkrufTuIswjWPgFwfHCYI
link.rule.ids 230,315,730,783,787,867,888,21402,27938,27939,33760,33761,41136,42205,43821,51592,53808,53810
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFYILKq8SaMFInEBR7cR2nBPqUwu0K1S1Um9RHI_FSmxSmu2BI_-cmTx2tVQg5RDJVpLxjO0vnplvGHufeWkSbyviqXSxKnUZ5yrTsayM8VZkeehyYc6mZnKpvlzpq-HArR3CKsc1sVuofVPRGfkebi25yXEzN5-uf8ZUNYq8q0MJjftskxxaODE3D46n385XpyyE51M1ujNTu9eqLhxLSIrh0kks1zekOyjzbrDkXx7TbiM62WKPBwTJ93uVP2H3oH7KHvQ1JX89Y78Pmhr4vMHxa9A4KEeRd2QMs5pTsEZJ-ed81vIboCBg8BxhKz_fP9Iy7tJIEILyeUk0EsTFAbwJnIhc58B7agmE7XjHxxBWDrWnLK4faMic3ADtc3Z5cnxxOImHOgtxpTKxiHWeA66_stQVJIBo20tQJlhblYl0pREgtIU0ScEKD9K4yokkV8GJEDQEkb5gGzXK9pJxSH0VlLBO5E4ZGSxIp6WTqfQir2SI2IdxsIvrnk6j6NzgqS16zRSomYI0U8iI7YzqKIaZ1RYrO4jYu2UzzgmSsKyhucU-kor14p8ePmK7197ybeSnTRDoRSxb0-uyA_Ftr7fUs-8d7za5cBFuRezjaAGrz_qnEK_-L8Rb9nBycXZanH6efn3NHiW9XeK1wzYWN7ewi5Bn4d4Mdv0HLHcBrw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQEYgL4k2ggJE4gaLaie3Yx9KyKq8KISr1ZsXxWKzEJlWzPXDknzOTx1ZL4YCUQ6Q4D3vGyed8M98w9qqK0hTRNqRTGXJV6zp3qtK5bIyJVlQuDbkwn4_N0Yn6cKpPpzqn_RztPlOSY04DqTS1672zmKYkcbvXqyGmSkgKxNJFjsuf64qqkxBbaw4uf7IQnC_VzGb-7czt79EVkHk1VvIPwnT4Di3usNsTgOT7o8XvsmvQ3mM3xpKSP--zX2-7Fviqw-Hr0DcoRZEPWgzLllOsRk3p53zZ83OgGGCIHFEr_7p_qGU-ZJEgAuWrmlQkSIoDeJc46biugI_KEojacY_PEawc2khJXD_QjzmxAP0DdrJ49-3gKJ_KLOSNqsQ6184Bvn5lrRsoAMF2lKBMsrapCxlqI0BoC2VRghURpAlNEIVTKYiUNCRRPmQ7LfbtMeNQxiYpYYNwQRmZLMigZZCljMI1MmXs9TzY_mxU0_ADC15aP1rGo2U8WcbLjO3O5vDTxOo9IgxnHGI6k7GXm8M4JaiHdQvdBbaRVKsXF3p4iUej9TZ3I5q2QJyXsWrLrpsGJLe9faRdfh9kt4nBRbSVsTezB1w-1j878eS_Wr9gN78cLvyn98cfn7JbxeiluO2ynfX5BTxD_LMOzwcf_w08jwC4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bone+morphogenetic+protein+signaling+is+required+for+RAD51-mediated+maintenance+of+genome+integrity+in+vascular+endothelial+cells&rft.jtitle=Communications+biology&rft.au=Vattulainen-Collanus%2C+Sanna&rft.au=Southwood%2C+Mark&rft.au=Yang%2C+Xu+Dong&rft.au=Moore%2C+Stephen&rft.date=2018-01-01&rft.eissn=2399-3642&rft.volume=1&rft.spage=149&rft.epage=149&rft_id=info:doi/10.1038%2Fs42003-018-0152-1&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon