Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia

• Published in: Scientific reports Vol. 12; no. 1; pp. 7351 - 11
• Main Authors: Guardiola-Ripoll, Maria, Sotero-Moreno, Alejandro, Almodóvar-Payá, Carmen, Hostalet, Noemí, Guerrero-Pedraza, Amalia, Ramiro, Núria, Ortiz-Gil, Jordi, Arias, Bárbara, Madre, Mercè, Soler-Vidal, Joan, Salvador, Raymond, McKenna, Peter J., Pomarol-Clotet, Edith, Fatjó-Vilas, Mar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 631/208/205; 631/208/366; 631/208/721; 631/208/727; 631/208/728; 639/766/930/2735; 692/308/53; 692/308/53/2421; 692/499; 692/699/476; 692/699/476/1761; 692/699/476/1799; Brain - metabolism; Brain mapping; Cortex (cingulate); Cortex (parietal); Diagnosis; Disc1 protein; Functional magnetic resonance imaging; Genetics; Haplotypes; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging; Memory, Short-Term; Mental disorders; multidisciplinary; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system; Neuroimaging; Neurosciences; Phenotypes; Polymorphism, Single Nucleotide; Psychosis; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - genetics; Science; Science (multidisciplinary); Short term memory

The DISC1 gene is one of the most relevant susceptibility genes for psychosis. However, the complex genetic landscape of this locus, which includes protective and risk variants in interaction, may have hindered consistent conclusions on how DISC1 contributes to schizophrenia (SZ) liability. Analysis...