PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells

• Published in: The Science of the total environment Vol. 710; p. 136397
• Main Authors: Wang, Yan, Tang, Meng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.03.2020
• Subjects: Apoptosis; Autophagic flux; Autophagy; cardiovascular system; cell viability; endoplasmic reticulum; Endoplasmic Reticulum Stress; Endothelial Cells; ER stress; homeostasis; Humans; lysosomes; Particulate Matter; particulates; PM2.5; protective effect; ER stress; Autophagy; PM2.5; Autophagic flux; Apoptosis

Endothelial cells integrally form a crucial interface that maintains homeostasis of the cardiovascular system. As a vulnerable target of PM2.5, the underlying mechanisms of endothelial cell damage have yet to be fully elucidated. In the current study, two types of cell death, including autophagy and...