Brazilin from Caesalpinia sappan inhibits viral infection against PRRSV via CD163ΔSRCR5 MARC-145 cells: an in silico and in vitro studies

• Published in: Scientific reports Vol. 12; no. 1; pp. 21595 - 15
• Main Authors: Arjin, Chaiwat, Tateing, Suriya, Potapohn, Nuttha, Arunorat, Jirapat, Pringproa, Kidsadagon, Lumsangkul, Chompunut, Seel-audom, Mintra, Ruksiriwanich, Warintorn, Sringarm, Korawan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/2248; 631/326/596; Animal diseases; Animals; Antiviral activity; Antiviral drugs; Bioactive compounds; Caesalpinia - chemistry; Caesalpinia sappan; Catechin; CD163 antigen; Computer applications; Conformation; Epicatechin; Free energy; Humanities and Social Sciences; Infections; Molecular Docking Simulation; multidisciplinary; Porcine Reproductive and Respiratory Syndrome - drug therapy; Porcine respiratory and reproductive syndrome virus; Scavenger receptors; Science; Science (multidisciplinary); Swine; Viral infections; Virus Diseases

This research aimed to identify bioactive compounds from Caesalpinia sappan extract that function as novel porcine reproductive and respiratory syndrome virus (PRRSV) infection inhibitors by computational molecular screening. We obtained a set of small-molecule compounds predicted to target the scav...