The multiplex network of human diseases

• Published in: NPJ systems biology and applications Vol. 5; no. 1; p. 15
• Main Authors: Halu, Arda, De Domenico, Manlio, Arenas, Alex, Sharma, Amitabh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.04.2019; Nature Publishing Group
• Subjects: 631/114; 631/553; Bioinformatics; Biomedical and Life Sciences; Classification; Classification systems; Computational Biology - methods; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Disease - classification; Disease - genetics; Gene Regulatory Networks - genetics; Gene Regulatory Networks - physiology; Genotype; Genotype & phenotype; Genotypes; Humans; Life Sciences; Phenotype; Phenotypes; Precision medicine; Risk factors; Systems Biology; Systems biology; Computational biology and bioinformatics

Untangling the complex interplay between phenotype and genotype is crucial to the effective characterization and subtyping of diseases. Here we build and analyze the multiplex network of 779 human diseases, which consists of a genotype-based layer and a phenotype-based layer. We show that diseases w...