Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats

• Published in: Psychopharmacologia Vol. 211; no. 4; pp. 367 - 375
• Main Authors: Cippitelli, Andrea, Karlsson, Camilla, Shaw, Janice L., Thorsell, Annika, Gehlert, Donald R., Heilig, Markus
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.09.2010; Springer; Springer Nature B.V
• Subjects: Alcohol; Alcohol Drinking - prevention & control; Animal behavior; Animals; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - pharmacology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Dose-Response Relationship, Drug; Drug addictions; Drug Delivery Systems; Footshock; Hormones; Male; MCH1-R; Medical sciences; Miscellaneous; Motor Activity - drug effects; Neurosciences; Original Investigation; Pharmacology. Drug treatments; Pharmacology/Toxicology; Psychiatry; Psychopharmacology; Pyrimidinones - administration & dosage; Pyrimidinones - pharmacology; Rats; Rats, Wistar; Receptors, Somatostatin - antagonists & inhibitors; Reinstatement; Reward; Rodents; Saccharin; Secondary Prevention; Seeking; Self Administration; Taste - drug effects; Thiophenes - administration & dosage; Thiophenes - pharmacology; Toxicology; Footshock; Alcohol; Saccharin; MCH1-R; Seeking; Reinstatement; Affect affectivity; Rat; Rodentia; Emotion emotionality; Self administration; Experimental study; Alcoholic beverage; Vertebrata; Mammalia; Animal; Melanin concentrating hormone

Rationale Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction. Materials and methods We evaluated the effects of the non-peptide MCH1 receptor antagonist, GW803430 [6-(4-chl...