Glutathione Peroxidase 3 Serum Levels and GPX3 Gene Polymorphisms in Subjects with Metabolic Syndrome

• Published in: Archives of medical research Vol. 45; no. 5; pp. 375 - 382
• Main Authors: Baez-Duarte, Blanca G., Mendoza-Carrera, Francisco, García-Zapién, Alejandra, Flores-Martínez, Silvia E., Sánchez-Corona, José, Zamora-Ginez, Irma, Torres-Rasgado, Enrique, León-Chávez, Bertha A., Pérez-Fuentes, Ricardo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2014
• Subjects: Adult; Biomarkers - blood; Cardiovascular Diseases - etiology; Cardiovascular risk; Case-Control Studies; Female; Gene Frequency; Genetic Markers; Glutathione Peroxidase - blood; Glutathione Peroxidase - genetics; Glutathione peroxidase 3; GPX3·gene polymorphisms; Haplotypes; Humans; Insulin Resistance - genetics; Internal Medicine; Linkage Disequilibrium; Logistic Models; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Metabolic Syndrome - diagnosis; Metabolic Syndrome - genetics; Mexico; Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Sequence Analysis, DNA; Glutathione peroxidase 3; Metabolic syndrome; GPX3·gene polymorphisms; Cardiovascular risk

Glutathione peroxidase 3 (GPx3) plays a main role in removing hydro- and lipoperoxides from the body. Changes in concentration and several single-nucleotide polymorphisms (SNP) at the GPX3 gene have been associated with vascular diseases, but the relationship of GPx3 with metabolic syndrome (MetS) r...