Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells

• Published in: Cell death & disease Vol. 10; no. 8; pp. 588 - 14
• Main Authors: Zeng, Qi, Liu, Yi-min, Liu, Jun, Han, Jian, Guo, Jian-xin, Lu, Shun, Huang, Xue-mei, Yi, Ping, Lang, Jin-yi, Zhang, Peng, Wang, Chun-ting
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2019; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; 14/1; 14/19; 64/116; 64/60; 692/699/67/1059; 692/699/67/395; 82/51; 82/79; 96/109; 96/2; Adult; Aged; Aged, 80 and over; AKT protein; Animals; Antibodies; Antitumor activity; Apoptosis; Apoptosis - genetics; Apoptosis - radiation effects; Biochemistry; Biomedical and Life Sciences; Cation Transport Proteins - antagonists & inhibitors; Cation Transport Proteins - genetics; Cell Biology; Cell Culture; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cytology; Epithelial cells; Epithelial-Mesenchymal Transition - genetics; Female; Follow-Up Studies; Glycogen; Glycogen synthase kinase 3; Growth inhibition; HEK293 Cells; Humans; Immunology; Invasiveness; Ionizing radiation; Kaplan-Meier Estimate; Kinases; Life Sciences; Lymph nodes; Male; Mesenchyme; Metastases; Metastasis; Mice; Mice, Nude; Middle Aged; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - mortality; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Phosphatidylinositol 3-Kinases - metabolism; Protein arrays; Proto-Oncogene Proteins c-akt - metabolism; Radiation therapy; Radiation Tolerance - genetics; Radiation, Ionizing; Radiosensitivity; Signal transduction; Throat cancer; Transfection; Tumor Burden - genetics; Tumor Burden - radiation effects; Tumorigenesis; Xenograft Model Antitumor Assays; Young Adult; Zebrafish - embryology; Zinc transporter

ZIP4 is a zinc transporter involved in epithelial cell morphology and migration in various cancers. In the epithelial-to-mesenchymal transition (EMT), epithelial cells transition into mesenchymal cells. The EMT plays a crucial role in invasiveness and metastasis during tumorigenesis. The aim of this...