Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

• Published in: Journal of Virology Vol. 86; no. 20; pp. 11128 - 11137
• Main Authors: Tanaka, Tomohisa, Kamitani, Wataru, DeDiego, Marta L., Enjuanes, Luis, Matsuura, Yoshiharu
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2012
• Subjects: 5' Untranslated Regions; Biological and medical sciences; Cell Line; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Viral; Genome and Regulation of Viral Gene Expression; HEK293 Cells; Humans; Inverted Repeat Sequences; Microbiology; Miscellaneous; Peptide Chain Elongation, Translational; Ribosome Subunits, Small, Eukaryotic - metabolism; RNA Replicase - genetics; RNA Replicase - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Untranslated - metabolism; RNA, Viral - genetics; RNA, Viral - metabolism; SARS Virus - genetics; SARS Virus - metabolism; Severe Acute Respiratory Syndrome - genetics; Severe Acute Respiratory Syndrome - metabolism; Severe Acute Respiratory Syndrome - virology; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Virology; Virus Replication - genetics; Infection; Virus; Lung disease; Coronavirus; Messenger RNA; Respiratory disease; Viral disease; Severe acute respiratory syndrome; Coronaviridae; Genetic translation; Nidovirales

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