Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia

• Published in: European radiology Vol. 29; no. 1; pp. 46 - 56
• Main Authors: Varga, Andrea, Di Leo, Giovanni, Banga, Péter Vince, Csobay-Novák, Csaba, Kolossváry, Márton, Maurovich-Horvat, Pál, Hüttl, Kálmán
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2019; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Angiography; Brain; Brain Ischemia - diagnosis; Brain Ischemia - etiology; Carotid arteries; Carotid artery; Carotid Stenosis - complications; Carotid Stenosis - diagnosis; Circle of Willis - diagnostic imaging; Computed tomography; Computed Tomography Angiography - methods; Configurations; Diagnostic Radiology; Female; Humans; Hypoplasia; Imaging; Internal Medicine; Interventional Radiology; Ischemia; Male; Males; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Morphology; Multidetector Computed Tomography - methods; Multivariate analysis; Neuroradiology; Patients; Radiology; Regression analysis; Reproducibility of Results; Retrospective Studies; Statistical analysis; Stenosis; Ultrasound; Variance analysis; Vascular-Interventional; CT Angiography; Endarterectomy, Carotid; Carotid Artery, Internal; Anatomy; Circle of Willis
• DOI: 10.1007/s00330-018-5577-x
• ISSN: 0938-7994; 1432-1084

Purpose (1) to estimate the prevalence of Circle of Willis (CoW) variants in patients undergoing carotid endarterectomy, (2) to correlate these variants to controls and (3) cerebral ischemia depicted by computed tomography (CT). Materials and methods After Institutional Review Board approval, data of 544 carotid endarterectomy patients (331 males, mean age 69±8 years) and 196 controls (117 males, mean age 66±11 years) who underwent brain CT and carotid CT angiography (CTA) were retrospectively analysed. Two observers independently classified each CoW segment as normal, hypoplastic (diameter <0.8 mm) or non-visualized. Four groups of CoW variants based on the number of hypoplastic/non-visualized segments were correlated with clinical data (ANOVA, χ 2 and multivariate logistic regression analysis). Intra- and inter-observer agreement was estimated using Cohen κ statistics. Results High prevalence of CoW variants (97%) and compromised CoW (81%) was observed in the study group and significant difference was found in the distribution of CoW variants compared to controls ( p <0.001), internal carotid artery (ICA) stenosis being the only independent predictor of CoW morphology ( p <0.001). Significant correlation was found between CoW configuration and brain ischemia in the study group ( p =0.002). ICA stenosis of ≥90% was associated to higher rate of ipsilateral A1 hypoplasia/non-visualization ( p <0.001). Intra- and inter-observer agreement was from substantial to almost perfect (Cohen κ=0.75–1.0). Conclusion Highly variable CoW morphology was demonstrated in patients undergoing endarterectomy compared to controls. Likely compromised CoW in relation to cerebral ischemia was observed in a large cohort of carotid endarterectomy subjects. Key points • CoW variant distribution significantly differed in the study and control groups (p<0.001). • ICA stenosis was the only independent predictor of CoW morphology (p<0.001). • Severely compromised CoW configuration showed significant association with brain ischemia (p=0.002).