Emerging role of liver X receptors in cardiac pathophysiology and heart failure

• Published in: Basic Research in Cardiology Vol. 111; no. 1; p. 3
• Main Authors: Cannon, Megan V., van Gilst, Wiek H., de Boer, Rudolf A.
• Format: Journal Article Book Review
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2016; Springer Nature B.V
• Subjects: Animals; Cardiology; Heart - physiopathology; Heart Failure - metabolism; Heart Failure - physiopathology; Humans; Liver X Receptors; Medicine; Medicine & Public Health; Myocytes, Cardiac - metabolism; Orphan Nuclear Receptors - metabolism; Review; Heart failure; Cardiac remodeling; Liver X receptors; Metabolism; Cardiovascular risk factors; Hypertrophy

Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial e...