Treatment resistance in urothelial carcinoma: an evolutionary perspective

• Published in: Nature reviews. Clinical oncology Vol. 15; no. 8; pp. 495 - 509
• Main Authors: Vlachostergios, Panagiotis J, Faltas, Bishoy M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.08.2018
• Subjects: Bladder cancer; Chemotherapy; Cisplatin; Clonal selection; Deoxyribonucleic acid; DNA; Evolutionary genetics; Immune checkpoint inhibitors; Immunostimulation; Immunotherapy; Major histocompatibility complex; Mutagenesis; Mutation; Neoantigens; Patients; Precision medicine; Treatment resistance; Tumors; Urothelial carcinoma

The emergence of treatment-resistant clones is a critical barrier to cure in patients with urothelial carcinoma. Setting the stage for the evolution of resistance, urothelial carcinoma is characterized by extensive mutational heterogeneity, which is detectable even in patients with early stage disea...