The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine

• Published in: Cell death & disease Vol. 10; no. 3; p. 240
• Main Authors: Chu, Yu-De, Lai, Hsin-Yu, Pai, Li-Mei, Huang, Ya-Hui, Lin, Yang-Hsiang, Liang, Kung-Hao, Yeh, Chau-Ting
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.03.2019; Springer Nature B.V
• Subjects: 13; 13/2; 13/44; 14; 38; 38/61; 42; 45; 631/67/1504/1610; 631/80/83; 64; Adenosylmethionine; Animals; Antibodies; Antisense RNA; Apoptosis - genetics; Binding sites; Biochemistry; Biomedical and Life Sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Caveolin; Caveolin 1 - antagonists & inhibitors; Caveolin 1 - genetics; Caveolin 1 - metabolism; Caveolin-1; Cell Biology; Cell Culture; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Cohort Studies; Deoxyadenosines - metabolism; Dioxygenase; Dioxygenases - genetics; Dioxygenases - metabolism; DNA Methylation; DNA microarrays; Down-Regulation; Epigenesis, Genetic; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genomes; Hepatocellular carcinoma; Hepatoma; Humans; Immunology; Life Sciences; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Methionine; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Prognosis; Promoter Regions, Genetic; Prostate cancer; S-Adenosylmethionine; S-Adenosylmethionine - metabolism; Thionucleosides - metabolism; Transplantation, Heterologous; Tumor suppressor genes; Xenografts

The 5′-methylthioadenosine (MTA) cycle-participating human acireductone dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its role remains unclear in hepatocellular carcinoma (HCC). Here, we demonstrated a significant reduction of ADI1, either in protein or mRNA...