Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 14; p. 4523
Main Authors Xiong, Ruo-Gu, Huang, Si-Yu, Wu, Si-Xia, Zhou, Dan-Dan, Yang, Zhi-Jun, Saimaiti, Adila, Zhao, Cai-Ning, Shang, Ao, Zhang, Yun-Jian, Gan, Ren-You, Li, Hua-Bin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 15.07.2022
MDPI
Subjects
anticancer
Antidiabetics
Apoptosis
berberine
bioavailability
Brain cancer
Breast cancer
Cancer therapies
Cell adhesion & migration
Cell cycle
Cell growth
Chemokines
Cyclin-dependent kinases
Drugs
Gastric cancer
Gene amplification
Inflammation
Kinases
Lung cancer
mechanism
Metastasis
Microbiota
Prevention
Proteins
Review
safety
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Abstract Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.
AbstractList Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.
Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.
Author Yang, Zhi-Jun
Huang, Si-Yu
Zhou, Dan-Dan
Gan, Ren-You
Zhao, Cai-Ning
Zhang, Yun-Jian
Saimaiti, Adila
Shang, Ao
Li, Hua-Bin
Wu, Si-Xia
Xiong, Ruo-Gu
AuthorAffiliation 1 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; xiongrg@mail2.sysu.edu.cn (R.-G.X.); huangsy9@mail2.sysu.edu.cn (S.-Y.H.); wusx6@mail2.sysu.edu.cn (S.-X.W.); zhoudd6@mail2.sysu.edu.cn (D.-D.Z.); yangzhj57@mail2.sysu.edu.cn (Z.-J.Y.); saimaiti@mail2.sysu.edu.cn (A.S.)
4 Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; zhyunj2@mail.sysu.edu.cn
5 Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, National Agricultural Science & Technology Center, Chengdu 610213, China; ganrenyou@caas.cn
2 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; zhaocn@connect.hku.hk
3 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077
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– name: 1 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; xiongrg@mail2.sysu.edu.cn (R.-G.X.); huangsy9@mail2.sysu.edu.cn (S.-Y.H.); wusx6@mail2.sysu.edu.cn (S.-X.W.); zhoudd6@mail2.sysu.edu.cn (D.-D.Z.); yangzhj57@mail2.sysu.edu.cn (Z.-J.Y.); saimaiti@mail2.sysu.edu.cn (A.S.)
– name: 3 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; shangao@connect.hku.hk
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PublicationDate_xml – month: 7
  year: 2022
  text: 20220715
  day: 15
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle Molecules (Basel, Switzerland)
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant,...
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SubjectTerms anticancer
Antidiabetics
Apoptosis
berberine
bioavailability
Brain cancer
Breast cancer
Cancer therapies
Cell adhesion & migration
Cell cycle
Cell growth
Chemokines
Cyclin-dependent kinases
Drugs
Gastric cancer
Gene amplification
Inflammation
Kinases
Lung cancer
mechanism
Metastasis
Microbiota
Prevention
Proteins
Review
safety
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Title Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review
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