DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-α Production
The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of Artemisia asiatica N...
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| Published in | Journal of Health Science Vol. 52; no. 4; pp. 383 - 389 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
The Pharmaceutical Society of Japan
2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1344-9702 1347-5207 |
| DOI | 10.1248/jhs.52.383 |
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| Abstract | The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of Artemisia asiatica Nakai (DA-9601) has been reported to have anti-oxidative and anti-inflammatory activities. In this report, we investigated the effect of DA-9601 on the immediate-type allergic reaction and studied its possible mechanisms of action, focusing on the mast cell-mediated allergic reaction. DA-9601 inhibited compound 48/80-induced systemic anaphylactic reactions and serum histamine release in mice. DA-9601 decreased the IgE-mediated passive cutaneous anaphylaxis, the model of local allergic reaction in vivo. DA-9601 dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. Furthermore, DA-9601 decreased the gene expression and production of tumor necrosis factor (TNF)-α in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. These findings provide evidence that DA-9601 could be a candidate as an anti-allergic agent. |
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| AbstractList | The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of Artemisia asiatica Nakai (DA-9601) has been reported to have anti-oxidative and anti-inflammatory activities. In this report, we investigated the effect of DA-9601 on the immediate-type allergic reaction and studied its possible mechanisms of action, focusing on the mast cell-mediated allergic reaction. DA-9601 inhibited compound 48/80-induced systemic anaphylactic reactions and serum histamine release in mice. DA-9601 decreased the IgE-mediated passive cutaneous anaphylaxis, the model of local allergic reaction in vivo. DA-9601 dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. Furthermore, DA-9601 decreased the gene expression and production of tumor necrosis factor (TNF)-α in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. These findings provide evidence that DA-9601 could be a candidate as an anti-allergic agent. |
| Author | Oh, Tae-Young Kim, Sug-Hyun Chung, Jae Myung Moon, Jin-Young Park, Hyo-Hyun Lee, Soyoung Kim, Cheorl-Ho Kim, Sang-Hyun Park, Won-Hwan Jun, Chang-Duk |
| Author_xml | – sequence: 1 fullname: Kim, Sug-Hyun organization: Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University – sequence: 1 fullname: Moon, Jin-Young organization: Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University – sequence: 1 fullname: Jun, Chang-Duk organization: Department of Life Science, Gwangju Institutive of Science and Technology – sequence: 1 fullname: Kim, Cheorl-Ho organization: Department of Biological Science, SungKyunKwan University – sequence: 1 fullname: Oh, Tae-Young organization: Dong-A Pharmaceutical Research Institute – sequence: 1 fullname: Chung, Jae Myung organization: Department of Emergency Medicine, Kyungpook National University Hospital – sequence: 1 fullname: Lee, Soyoung organization: Department of Pharmacology, School of Medicine, Kyungpook National University – sequence: 1 fullname: Kim, Sang-Hyun organization: Department of Pharmacology, School of Medicine, Kyungpook National University – sequence: 1 fullname: Park, Won-Hwan organization: Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University – sequence: 1 fullname: Park, Hyo-Hyun organization: Department of Pharmacology, School of Medicine, Kyungpook National University |
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| CitedBy_id | crossref_primary_10_1371_journal_pone_0312670 crossref_primary_10_1016_j_intimp_2011_04_005 |
| Cites_doi | 10.1067/mai.2002.126811 10.1177/153537020523000911 10.1016/0091-6749(92)90107-D 10.4049/jimmunol.151.7.3853 10.1016/j.taap.2005.04.011 10.4049/jimmunol.139.8.2605 10.1159/000090383 10.1016/S0952-7915(05)80005-6 10.1073/pnas.88.10.4220 10.1016/S0891-5849(01)00472-5 10.1136/gut.49.3.364 10.1016/S0091-6749(97)70089-7 10.1038/339064a0 10.1002/ijc.10489 10.1016/S0091-6749(96)70313-5 10.1016/S0887-2333(03)00040-7 10.1177/153537020523000111 10.1007/BF02975366 10.1111/j.1476-5381.1980.tb07940.x 10.1016/0165-2478(90)90207-7 |
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| References | 7) Kim, S. H., Choi, C. H., Kim, S. Y., Eun, J. S. and Shin, T. Y. (2005) Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model. Exp. Biol. Med. (Maywood), 230, 82-88. 8) Kim, S. H. and Shin, T. Y. (2005) Amomum xanthiodes inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Exp. Biol. Med. (Maywood), 230, 681-687. 20) Kim, S. H. and Sharma, R. P. (2003) Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines: involvement of reactive oxygen species, Ca(2+) homeostasis, and cytokine gene expression. Toxicol. In Vitro, 17, 385-395. 21) Yang, E. K. and Kim, I. (2001) Pulse exposure to ethanol augments vascular contractility through stress response. Korean J. Physiol. Pharmacol., 5, 47-53. 12) Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P. and Paul, W. E. (1989) Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (London), 339, 64-67. 2) Metcalfe, D. D., Kaliner, M. and Donlon, M. A. (1981) The mast cell. Crit. Rev. Immunol., 3, 23-74. 9) Mican, J. A., Arora, N., Burd, P. R. and Metcalfe, D. D. (1992) Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J. Allergy Clin. Immunol., 90, 815-824. 4) Petersen, L. J., Mosbech, H. and Skov, P. S. (1996) Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol., 97, 672-679. 14) Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W. and Hahm, K. B. (2001) Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment. Free Radic. Biol. Med., 30, 905-915. 15) Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W., Lee, K. M. and Hahm, K. B. (2001) Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut, 49, 364-371. 23) Mousli, M., Bronner, C., Bockaert, J., Rouot, B. and Landry, Y. (1990) Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein. Immunol. Lett., 25, 355-357. 25) Tasaka, K., Mio, M. and Okamoto, M. (1986) Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy, 56, 464-469. 13) Seo, H. J., Park, K. K., Han, S. S., Chung, W. Y., Son, M. W., Kim, W. B. and Surh, Y. J. (2002) Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Int. J. Cancer, 100, 456-462. 5) Ennis, M., Pearce, F. L. and Weston, P. M. (1980) Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol., 70, 329-334. 27) Sillaber, C., Bevec, D., Butterfield, J. H., Heppner, C., Valenta, R., Scheiner, O., Kraft, D., Lechner, K., Bettelheim, P. and Valent, P. (1993) Tumor necrosis factor alpha and interleukin-1 beta mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4. Exp. Hematol., 21, 1271-1275. 1) Kemp, S. F. and Lockey, R. F. (2002) Anaphylaxis: a review of causes and mechanisms. J. Allergy Clin. Immunol., 110, 341-348. 10) Bradding, P., Feather, I. H., Wilson, S., Bardin, P. G., Heusser, C. H., Holgate, S. T. and Howarth, P. H. (1993) Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J. Immunol., 151, 3853-3865. 16) Lee, J. S., Oh, T. Y., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Kim, H. J. and Hahm, K. B. (2001) Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants. Mutat. Res., 480-481, 189-200. 18) Kim, S. H. and Shin, T. Y. (2006) Effect of Dracocephalum argunense on Mast-Cell-Mediated Hypersensitivity. Int. Arch. Allergy Immunol., 139, 87-95. 11) Galli, S. J., Gordon, J. R. and Wershil, B. K. (1991) Cytokine production by mast cells and basophils. Curr. Opin. Immunol., 3, 865-872. 26) Walsh, L. J., Trinchieri, G., Waldorf, H. A., Whitaker, D. and Murphy, G. F. (1991) Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A., 88, 4220-4224. 6) Lagunoff, D., Martin, T. W. and Read, G. (1983) Agents that release histamine from mast cells. Annu. Rev. Pharmacol. Toxicol., 23, 331-351. 24) Bueb, J. L., Mousli, M., Bronner, C., Rouot, B. and Landry, Y. (1990) Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mol. Pharmacol., 38, 816-822. 17) Ryu, B. K., Ahn, B. O., Oh, T. Y., Kim, S. H., Kim, W. B. and Lee, E. B. (1998) Studies on protective effect of DA-9601, Artemisia asiatica extract, on acetaminophen- and CCl4-induced liver damage in rats. Arch. Pharm. Res., 21, 508-513. 3) Church, M. K. and Levi-Schaffer, F. (1997) The human mast cell. J. Allergy Clin. Immunol., 99, 155-160. 19) Shin, T. Y., Kim, S. H., Suk, K., Ha, J. H., Kim, I., Lee, M. G., Jun, C. D., Kim, S. Y., Lim, J. P., Eun, J. S., Shin, H. Y. and Kim, H. M. (2005) Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model. Toxicol. Appl. Pharmacol., 209, 255-262. 22) Wershil, B. K., Mekori, Y. A., Murakami, T. and Galli, S. J. (1987) 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J. Immunol., 139, 2605-2614. 23 Kemp, S. F. and Lockey, R. F. (1) 2002; 110 Wershil, B. K., Mekori, Y. A., Murakami, T. and Galli, S. J. (22) 1987; 139 Lagunoff, D., Martin, T. W. and Read, G. (6) 1983; 23 RYU B K (17) 1998; 21 Kim, S. H. and Sharma, R. P. (20) 2003; 17 11 (26) 1991; 88 12 Sillaber, C., Bevec, D., Butterfield, J. H., Heppner, C., Valenta, R., Scheiner, O., Kraft, D., Lechner, K., Bettelheim, P. and Valent, P. (27) 1993; 21 Kim, S. H. and Shin, T. Y. (8) 2005; 230 (10) 1993; 151 19 Yang, E. K. and Kim, I. (21) 2001; 5 Kim, S. H. and Shin, T. Y. (18) 2006; 139 Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W., Lee, K. M. and Hahm, K. B. (15) 2001; 49 Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W. and Hahm, K. B. (14) 2001; 30 3 Lee, J. S., Oh, T. Y., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Kim, H. J. and Hahm, K. B. (16) 2001; 480 4 Ennis M., Pearce F. L., Weston P. M. (5) 1980; 70 9 Metcalfe, D. D., Kaliner, M. and Donlon, M. A. (2) 1981; 3 Kim, S. H., Choi, C. H., Kim, S. Y., Eun, J. S. and Shin, T. Y. (7) 2005; 230 (24) 1990; 38 Tasaka, K., Mio, M. and Okamoto, M. (25) 1986; 56 Seo, H. J., Park, K. K., Han, S. S., Chung, W. Y., Son, M. W., Kim, W. B. and Surh, Y. J. (13) 2002; 100 |
| References_xml | – reference: 18) Kim, S. H. and Shin, T. Y. (2006) Effect of Dracocephalum argunense on Mast-Cell-Mediated Hypersensitivity. Int. Arch. Allergy Immunol., 139, 87-95. – reference: 11) Galli, S. J., Gordon, J. R. and Wershil, B. K. (1991) Cytokine production by mast cells and basophils. Curr. Opin. Immunol., 3, 865-872. – reference: 7) Kim, S. H., Choi, C. H., Kim, S. Y., Eun, J. S. and Shin, T. Y. (2005) Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model. Exp. Biol. Med. (Maywood), 230, 82-88. – reference: 9) Mican, J. A., Arora, N., Burd, P. R. and Metcalfe, D. D. (1992) Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J. Allergy Clin. Immunol., 90, 815-824. – reference: 26) Walsh, L. J., Trinchieri, G., Waldorf, H. A., Whitaker, D. and Murphy, G. F. (1991) Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A., 88, 4220-4224. – reference: 10) Bradding, P., Feather, I. H., Wilson, S., Bardin, P. G., Heusser, C. H., Holgate, S. T. and Howarth, P. H. (1993) Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J. Immunol., 151, 3853-3865. – reference: 17) Ryu, B. K., Ahn, B. O., Oh, T. Y., Kim, S. H., Kim, W. B. and Lee, E. B. (1998) Studies on protective effect of DA-9601, Artemisia asiatica extract, on acetaminophen- and CCl4-induced liver damage in rats. Arch. Pharm. Res., 21, 508-513. – reference: 3) Church, M. K. and Levi-Schaffer, F. (1997) The human mast cell. J. Allergy Clin. Immunol., 99, 155-160. – reference: 13) Seo, H. J., Park, K. K., Han, S. S., Chung, W. Y., Son, M. W., Kim, W. B. and Surh, Y. J. (2002) Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Int. J. Cancer, 100, 456-462. – reference: 2) Metcalfe, D. D., Kaliner, M. and Donlon, M. A. (1981) The mast cell. Crit. Rev. Immunol., 3, 23-74. – reference: 6) Lagunoff, D., Martin, T. W. and Read, G. (1983) Agents that release histamine from mast cells. Annu. Rev. Pharmacol. Toxicol., 23, 331-351. – reference: 22) Wershil, B. K., Mekori, Y. A., Murakami, T. and Galli, S. J. (1987) 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J. Immunol., 139, 2605-2614. – reference: 14) Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W. and Hahm, K. B. (2001) Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment. Free Radic. Biol. Med., 30, 905-915. – reference: 20) Kim, S. H. and Sharma, R. P. (2003) Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines: involvement of reactive oxygen species, Ca(2+) homeostasis, and cytokine gene expression. Toxicol. In Vitro, 17, 385-395. – reference: 23) Mousli, M., Bronner, C., Bockaert, J., Rouot, B. and Landry, Y. (1990) Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein. Immunol. Lett., 25, 355-357. – reference: 24) Bueb, J. L., Mousli, M., Bronner, C., Rouot, B. and Landry, Y. (1990) Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mol. Pharmacol., 38, 816-822. – reference: 4) Petersen, L. J., Mosbech, H. and Skov, P. S. (1996) Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol., 97, 672-679. – reference: 1) Kemp, S. F. and Lockey, R. F. (2002) Anaphylaxis: a review of causes and mechanisms. J. Allergy Clin. Immunol., 110, 341-348. – reference: 21) Yang, E. K. and Kim, I. (2001) Pulse exposure to ethanol augments vascular contractility through stress response. Korean J. Physiol. Pharmacol., 5, 47-53. – reference: 5) Ennis, M., Pearce, F. L. and Weston, P. M. (1980) Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol., 70, 329-334. – reference: 12) Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P. and Paul, W. E. (1989) Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (London), 339, 64-67. – reference: 15) Oh, T. Y., Lee, J. S., Ahn, B. O., Cho, H., Kim, W. B., Kim, Y. B., Surh, Y. J., Cho, S. W., Lee, K. M. and Hahm, K. B. (2001) Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut, 49, 364-371. – reference: 25) Tasaka, K., Mio, M. and Okamoto, M. (1986) Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy, 56, 464-469. – reference: 19) Shin, T. Y., Kim, S. H., Suk, K., Ha, J. H., Kim, I., Lee, M. G., Jun, C. D., Kim, S. Y., Lim, J. P., Eun, J. S., Shin, H. Y. and Kim, H. M. (2005) Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model. Toxicol. Appl. Pharmacol., 209, 255-262. – reference: 8) Kim, S. H. and Shin, T. Y. (2005) Amomum xanthiodes inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Exp. Biol. Med. (Maywood), 230, 681-687. – reference: 27) Sillaber, C., Bevec, D., Butterfield, J. 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| Title | DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-α Production |
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