Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

• Published in: Cell death and differentiation Vol. 27; no. 11; pp. 3196 - 3207
• Main Authors: Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, Ippolito, Giuseppe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2020; Nature Publishing Group
• Subjects: 13/21; 13/31; 631/250/255; 692/699/255; Adult; Apoptosis; Betacoronavirus - pathogenicity; Biochemistry; Biomedical and Life Sciences; CD4-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - immunology; CD95 antigen; Cell activation; Cell Biology; Cell Cycle Analysis; Convalescence; Coronavirus Infections - immunology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Cytokines - metabolism; Cytotoxicity; Disease Progression; Effector cells; Female; Humans; Immune response; Inflammation; Inflammation - immunology; Interleukin 6; Leukocytes (mononuclear); Life Sciences; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Lymphopenia; Myeloid-Derived Suppressor Cells - cytology; Myeloid-Derived Suppressor Cells - immunology; Neutrophilia; Pandemics; Peripheral blood; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Stem Cells; Suppressor cells

SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The pathogenesis of severe cases remains unknown. We performed an in-depth prospective analysis of immune and inflammation markers in two patients with severe COVID-19 disease from presentation to convalescence. Per...