Orbitofrontal dysfunction related to depressive symptomatology in subjects with borderline personality disorder
Abstract Objective In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Methods Seve...
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| Published in | Journal of affective disorders Vol. 134; no. 1; pp. 410 - 415 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Oxford
Elsevier B.V
01.11.2011
Elsevier |
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| Abstract | Abstract Objective In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Methods Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity. Results Although no interaction group × picture category × brain region was found, a significant interaction group × brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p < .05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: − 0.48, p < 0.05), with score in the Cornell Dysthymia rating scale (r: − 0.52, p < 0.05) and with the number of criteria met for depressive personality disorder (r: − 0.44, p < 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r − 0.63, p < 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms. Conclusions Abnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. |
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| AbstractList | Objective: In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Methods: Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity. Results: Although no interaction group x picture category x brain region was found, a significant interaction group x brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p .05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: -- 0.48, p 0.05), with score in the Cornell Dysthymia rating scale (r: -- 0.52, p 0.05) and with the number of criteria met for depressive personality disorder (r: -- 0.44, p 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r -- 0.63, p 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms. Conclusions: Abnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. [Copyright Elsevier B.V.] In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity. Although no interaction group × picture category × brain region was found, a significant interaction group × brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p<.05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: -0.48, p < 0.05), with score in the Cornell Dysthymia rating scale (r: -0.52, p < 0.05) and with the number of criteria met for depressive personality disorder (r: -0.44, p < 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r-0.63, p < 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms. Abnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. OBJECTIVEIn order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images.METHODSSeventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity.RESULTSAlthough no interaction group × picture category × brain region was found, a significant interaction group × brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p<.05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: -0.48, p < 0.05), with score in the Cornell Dysthymia rating scale (r: -0.52, p < 0.05) and with the number of criteria met for depressive personality disorder (r: -0.44, p < 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r-0.63, p < 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms.CONCLUSIONSAbnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity. Although no interaction group×picture category×brain region was found, a significant interaction group×brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F=26.4; p<.05; F=31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: −0.48, p<0.05), with score in the Cornell Dysthymia rating scale (r: −0.52, p<0.05) and with the number of criteria met for depressive personality disorder (r: −0.44, p<0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r−0.63, p<0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms. Abnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. Abstract Objective In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images. Methods Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity. Results Although no interaction group × picture category × brain region was found, a significant interaction group × brain region appeared for orbito-frontal cortex (OFC). BPD patients showed significantly reduced magnetocortical activity in left OFC across all picture categories (F = 26.4; p < .05; F = 31.4). Left OFC activity was inversely correlated with depression score in the BDI (r: − 0.48, p < 0.05), with score in the Cornell Dysthymia rating scale (r: − 0.52, p < 0.05) and with the number of criteria met for depressive personality disorder (r: − 0.44, p < 0.05). Left orbitofrontal activity was also inversely correlated with the global score in the GAF (r − 0.63, p < 0.01). No correlations were found between OFC activity and impulsivity or global severity of BPD symptoms. Conclusions Abnormal functioning at orbitofrontal areas in BPD could be related to the presence of affective symptomatology and is associated with greater functional deterioration of patients. |
| Author | López-Ibor, J.J Carrasco, J.L Díaz-Marsá, M Ortiz, T López-Ibor, M Montes, A Moratti, S |
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| Keywords | Orbito-frontal Dysthymia Affective Magnetoencephalography Brain function Borderline personality disorder Human Mood disorder Affect affectivity Orbitofrontal cortex Borderline Central nervous system Depression Personality disorder Encephalon Symptomatology |
| Language | English |
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| Snippet | Abstract Objective In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the... In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors... Objective: In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors... OBJECTIVEIn order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Affect Affective Biological and medical sciences Borderline personality disorder Borderline Personality Disorder - diagnosis Borderline Personality Disorder - physiopathology Borderline Personality Disorder - psychology Brain - physiopathology Brain function Brain Mapping Cortex Depression Depressive Disorder - physiopathology Dysfunction Dysthymia Emotions Evoked Potentials, Visual Female Frontal Lobe - physiopathology Humans Impulsive Behavior - psychology Impulsivity Magnetoencephalography Male Medical sciences Mood disorders Orbito-frontal Personality disorders Personality Inventory Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Stimulation Young Adult |
| Title | Orbitofrontal dysfunction related to depressive symptomatology in subjects with borderline personality disorder |
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