Reciprocal MicroRNA Expression in Mesocortical Circuit and Its Interplay with Serotonin Transporter Define Resilient Rats in the Chronic Mild Stress

• Published in: Molecular neurobiology Vol. 54; no. 8; pp. 5741 - 5751
• Main Authors: Zurawek, Dariusz, Kusmider, Maciej, Faron-Gorecka, Agata, Gruca, Piotr, Pabian, Paulina, Solich, Joanna, Kolasa, Magdalena, Papp, Mariusz, Dziedzicka-Wasylewska, Marta
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2017; Springer Nature B.V
• Subjects: Anhedonia - drug effects; Animals; Antidepressive Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Chronic illnesses; Depression - drug therapy; Depression - genetics; Disease Models, Animal; Gene expression; Gene Expression - drug effects; Hedonic response; Male; Mental depression; MicroRNAs; MicroRNAs - metabolism; miRNA; Neurobiology; Neurology; Neurosciences; Prefrontal cortex; Prefrontal Cortex - metabolism; Rats; Rats, Wistar; Rodents; Serotonin; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Stress; Stress, Psychological - genetics; Stress, Psychological - metabolism; Sucrose; Sugar; Ventral tegmentum; Depression; Chronic mild stress; MicroRNA; Serotonin transporter; Resilient; Stress

Prolonged stress perturbs physiological balance of a subject and thus can lead to depression. Nevertheless, some individuals are more resilient to stress than the others. Defining molecular factors underlying resilience to stress may contribute to the development of a new antidepressant strategy bas...