Reversal agents for non-vitamin K antagonist oral anticoagulants

• Published in: Nature reviews cardiology Vol. 15; no. 5; p. 273
• Main Authors: Levy, Jerrold H, Douketis, James, Weitz, Jeffrey I
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2018
• Subjects: Anticoagulants; Coagulation; Patients

The non-vitamin K antagonist oral anticoagulants (NOACs) include dabigatran, which inhibits thrombin, and apixaban, betrixaban, edoxaban, and rivaroxaban, which inhibit coagulation factor Xa. Although clinical studies of NOACs were conducted without antidotes, patient outcomes with major bleeding wh...