Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

• Published in: Nature immunology Vol. 21; no. 12; pp. 1552 - 1562
• Main Authors: Galletti, Giovanni, De Simone, Gabriele, Mazza, Emilia M. C., Puccio, Simone, Mezzanotte, Claudia, Bi, Timothy M., Davydov, Alexey N., Metsger, Maria, Scamardella, Eloise, Alvisi, Giorgia, De Paoli, Federica, Zanon, Veronica, Scarpa, Alice, Camisa, Barbara, Colombo, Federico S., Anselmo, Achille, Peano, Clelia, Polletti, Sara, Mavilio, Domenico, Gattinoni, Luca, Boi, Shannon K., Youngblood, Benjamin A., Jones, Rhiannon E., Baird, Duncan M., Gostick, Emma, Llewellyn-Lacey, Sian, Ladell, Kristin, Price, David A., Chudakov, Dmitriy M., Newell, Evan W., Casucci, Monica, Lugli, Enrico
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2020; Nature Publishing Group
• Subjects: 631/250/1619/554/1834; 631/250/2152/1566/1571; Animals; Antigens; Apoptosis; Biomarkers; Biomedical and Life Sciences; Biomedicine; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Differentiation - immunology; Computational Biology - methods; Gene Expression Profiling; Heterogeneity; High-Throughput Nucleotide Sequencing; Humans; Immunoglobulins; Immunologic Memory; Immunological memory; Immunology; Immunophenotyping; Immunoreceptor tyrosine-based inhibition motif; Immunotherapy; Infectious Diseases; Lymphocytes; Lymphocytes T; Lymphoid Progenitor Cells - cytology; Lymphoid Progenitor Cells - immunology; Lymphoid Progenitor Cells - metabolism; Memory cells; Mice; PD-1 protein; Progenitor cells; Ribonucleic acid; RNA; Stem cells; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Telomere Homeostasis; Transcription

T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We us...