Physiology-Based Pharmacokinetic Study on 18β-Glycyrrhetic Acid Mono-Glucuronide (GAMG) Prior to Glycyrrhizin in Rats

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 14; p. 4657
• Main Authors: Cao, Mengxin, Zuo, Jiawei, Yang, Jian-Guo, Wu, Chenyao, Yang, Yongan, Tang, Wenjian, Zhu, Lili
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 21.07.2022; MDPI
• Subjects: Accuracy; Acids; Biological products; GAMG; glycyrrhetic acid; glycyrrhizin; Metabolism; Metabolites; pharmacodynamics; Pharmacokinetics; Physiology; Plasma; tissue distribution; United States > US; China

To understand that 18β-Glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG) showed better pharmacological activity and drug-like properties than 18β-Glycyrrhizin (GL); a rapid and sensitive HPLC-MS/MS method was established for the simultaneous determination of GAMG and its metabolite 18β-Glycyrrhetini...