NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells

• Published in: Cell death & disease Vol. 10; no. 12; pp. 896 - 14
• Main Authors: Jones, Lauren G., Vaida, Andra, Thompson, Louise M., Ikuomola, Felix I., Caamaño, Jorge H., Burkitt, Michael D., Miyajima, Fabio, Williams, Jonathan M., Campbell, Barry J., Pritchard, D. Mark, Duckworth, Carrie A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.11.2019; Springer Nature B.V
• Subjects: 13/100; 13/106; 13/2; 13/21; 13/51; 14/63; 631/532/2118/2437; 64/60; 692/308/1426; 692/420/256/1980; 692/420/2780; 692/699/1503/257; 96/1; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Biochemistry; Biomedical and Life Sciences; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Caspase-3; Cell Biology; Cell Culture; Cell Degranulation - drug effects; Cell Proliferation - drug effects; Colitis; Colon; Culture Media, Conditioned - pharmacology; Degranulation; Dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Enterocytes - cytology; Enterocytes - drug effects; Enterocytes - metabolism; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Immunology; Inflammatory bowel diseases; Interferon-gamma - pharmacology; Intestine, Small - metabolism; Life Sciences; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Mice, Inbred C57BL; Mucosa; NF-kappa B p52 Subunit - metabolism; NF-κB protein; Organoids - metabolism; Paneth Cells - drug effects; Paneth Cells - metabolism; Permeability; Reproducibility of Results; Sepsis; Signal Transduction; Small intestine; Transcription; Tumor necrosis factor; Tumor Necrosis Factor-alpha - pharmacology; γ-Interferon

Alternative pathway NF-κB signalling regulates susceptibility towards developing inflammatory bowel disease (IBD), colitis-associated cancer and sepsis-associated intestinal epithelial cell apoptosis and shedding. However, the cell populations responsible for the perturbed alternative pathway NF-κB...