Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model
Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mo...
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Published in | Scientific reports Vol. 8; no. 1; pp. 7609 - 14 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
15.05.2018
Nature Publishing Group Nature Portfolio |
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Abstract | Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway. The combination of high throughput data analysis and the results of qRT-PCR validation in lungs of chronic CS-induced COPD mouse model, 16HBE cells with CSE treatment and PBMC from patients with COPD revealed that NR_102714 and its associated protein-coding gene UCHL1 might be involved in the development of COPD both in mouse and human. In conclusion, our study demonstrated that aberrant expression profiles of lncRNAs and mRNAs existed in lungs of chronic CS-induced COPD mouse model. From animal models perspective, these results might provide further clues to investigate biological functions of lncRNAs and their potential target protein-coding genes in the pathogenesis of COPD. |
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AbstractList | Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway. The combination of high throughput data analysis and the results of qRT-PCR validation in lungs of chronic CS-induced COPD mouse model, 16HBE cells with CSE treatment and PBMC from patients with COPD revealed that NR_102714 and its associated protein-coding gene UCHL1 might be involved in the development of COPD both in mouse and human. In conclusion, our study demonstrated that aberrant expression profiles of lncRNAs and mRNAs existed in lungs of chronic CS-induced COPD mouse model. From animal models perspective, these results might provide further clues to investigate biological functions of lncRNAs and their potential target protein-coding genes in the pathogenesis of COPD. Abstract Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway. The combination of high throughput data analysis and the results of qRT-PCR validation in lungs of chronic CS-induced COPD mouse model, 16HBE cells with CSE treatment and PBMC from patients with COPD revealed that NR_102714 and its associated protein-coding gene UCHL1 might be involved in the development of COPD both in mouse and human. In conclusion, our study demonstrated that aberrant expression profiles of lncRNAs and mRNAs existed in lungs of chronic CS-induced COPD mouse model. From animal models perspective, these results might provide further clues to investigate biological functions of lncRNAs and their potential target protein-coding genes in the pathogenesis of COPD. Abstract Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway. The combination of high throughput data analysis and the results of qRT-PCR validation in lungs of chronic CS-induced COPD mouse model, 16HBE cells with CSE treatment and PBMC from patients with COPD revealed that NR_102714 and its associated protein-coding gene UCHL1 might be involved in the development of COPD both in mouse and human. In conclusion, our study demonstrated that aberrant expression profiles of lncRNAs and mRNAs existed in lungs of chronic CS-induced COPD mouse model. From animal models perspective, these results might provide further clues to investigate biological functions of lncRNAs and their potential target protein-coding genes in the pathogenesis of COPD. |
ArticleNumber | 7609 |
Author | Sun, Dejun Li, Defu Zhang, Chenting Wang, Jian Zhang, Haiyun Liang, Xue Xu, Jingyi Zheng, Zeguang Wang, Sheng Lu, Wenju |
Author_xml | – sequence: 1 givenname: Haiyun surname: Zhang fullname: Zhang, Haiyun organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 2 givenname: Dejun surname: Sun fullname: Sun, Dejun organization: Division of Pulmonary Medicine, The People’s Hospital of Inner Mongolia, Inner Mongolia Medical University – sequence: 3 givenname: Defu surname: Li fullname: Li, Defu organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 4 givenname: Zeguang surname: Zheng fullname: Zheng, Zeguang organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 5 givenname: Jingyi surname: Xu fullname: Xu, Jingyi organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 6 givenname: Xue surname: Liang fullname: Liang, Xue organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 7 givenname: Chenting surname: Zhang fullname: Zhang, Chenting organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 8 givenname: Sheng orcidid: 0000-0001-5924-3929 surname: Wang fullname: Wang, Sheng organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University – sequence: 9 givenname: Jian surname: Wang fullname: Wang, Jian email: jianwang1986@yahoo.com organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Division of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona – sequence: 10 givenname: Wenju surname: Lu fullname: Lu, Wenju email: wlu92@yahoo.com organization: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29765063$$D View this record in MEDLINE/PubMed |
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Snippet | Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in... Abstract Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been... Abstract Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been... |
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SubjectTerms | 13/1 45/90 631/208/199 64/60 692/699/1785/4037 A549 Cells Animal models Animals Cells, Cultured Chronic obstructive pulmonary disease Cigarette smoke Data processing Disease Models, Animal Endoplasmic reticulum Gene expression Gene Expression Profiling - methods Gene Expression Regulation Gene Regulatory Networks - drug effects Humanities and Social Sciences Humans Lung - chemistry Lung - drug effects Lungs Male Mice multidisciplinary Non-coding RNA Peripheral blood mononuclear cells Proteins Pulmonary Disease, Chronic Obstructive - chemically induced Pulmonary Disease, Chronic Obstructive - genetics RNA, Long Noncoding - genetics Rodents Science Science (multidisciplinary) Sequence Analysis, RNA Taurine Tobacco Products - adverse effects Ubiquitin Thiolesterase - genetics |
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Title | Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model |
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