Synthesis of Hafnium(IV) Polyaminoacetates

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediam...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 12; p. 3725
Main Authors Shulyak, Alexandra T., Bortnikov, Evgeniy O., Kubasov, Alexey S., Selivanov, Nikita A., Lipengolts, Alexey A., Zhdanov, Andrey P., Bykov, Alexander Yu, Zhizhin, Konstantin Yu, Kuznetsov, Nikolai T.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 18.06.2021
MDPI
Subjects
Alcohol
Chloride
complexonates
contrast agent
Contrast agents
coordination chemistry
Crystal structure
Dichlorides
DTPA
Ethylenediamine
Hafnium
Ligands
Nitrilotriacetic acid
Salt
Salts
Single crystals
Sodium
structure elucidation
Toxicity
X-ray diffraction
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Abstract The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.
AbstractList The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.
The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N , N , N ′, N ′-tetraacetic acid (dpta), and N -(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na 2 [Hf(NTA) 2 ]·3H 2 O ( 1 ), Na[HfDTPA]·3H 2 O ( 2 ), [HfCDTA(H 2 O) 2 ] ( 3 ), and Na[Hf 2 (dpta) 2 ]·7.5H 2 O·0.5C 2 H 5 OH ( 4 ) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H 2 O) 2 ] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.
Author Shulyak, Alexandra T.
Zhdanov, Andrey P.
Selivanov, Nikita A.
Zhizhin, Konstantin Yu
Bykov, Alexander Yu
Kuznetsov, Nikolai T.
Lipengolts, Alexey A.
Bortnikov, Evgeniy O.
Kubasov, Alexey S.
AuthorAffiliation 3 Organic Chemistry Department, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; bortnikovevol@gmail.com
4 N.N. Blokhin National Medical Research Center of Oncology, Federal State Budgetary Institution, Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Kashirskoye Shosse 24, 115478 Moscow, Russia; lipengolz@gmail.com
2 Inorganic Chemistry Department, Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, pr. Vernadskogo, 86, 119454 Moscow, Russia
1 Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, Russia; fobosax@mail.ru (A.S.K.); govee@yandex.ru (N.A.S.); zhdanov@igic.ras.ru (A.P.Z.); bykov@igic.ras.ru (A.Y.B.); zhizhin@igic.ras.ru (K.Y.Z.); ntkuz@igic.ras.ru (N.T.K.)
AuthorAffiliation_xml – name: 2 Inorganic Chemistry Department, Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, pr. Vernadskogo, 86, 119454 Moscow, Russia
– name: 3 Organic Chemistry Department, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; bortnikovevol@gmail.com
– name: 1 Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, Russia; fobosax@mail.ru (A.S.K.); govee@yandex.ru (N.A.S.); zhdanov@igic.ras.ru (A.P.Z.); bykov@igic.ras.ru (A.Y.B.); zhizhin@igic.ras.ru (K.Y.Z.); ntkuz@igic.ras.ru (N.T.K.)
– name: 4 N.N. Blokhin National Medical Research Center of Oncology, Federal State Budgetary Institution, Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Kashirskoye Shosse 24, 115478 Moscow, Russia; lipengolz@gmail.com
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  fullname: Kuznetsov, Nikolai T.
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Snippet The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA),...
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StartPage 3725
SubjectTerms Alcohol
Chloride
complexonates
contrast agent
Contrast agents
coordination chemistry
Crystal structure
Dichlorides
DTPA
Ethylenediamine
Hafnium
Ligands
Nitrilotriacetic acid
Salt
Salts
Single crystals
Sodium
structure elucidation
Toxicity
X-ray diffraction
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Title Synthesis of Hafnium(IV) Polyaminoacetates
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https://pubmed.ncbi.nlm.nih.gov/PMC8234123
https://doaj.org/article/7cb4395e22bf43de8792102c23ee6b44
Volume 26
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