Synthesis of Hafnium(IV) Polyaminoacetates

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 12; p. 3725
• Main Authors: Shulyak, Alexandra T., Bortnikov, Evgeniy O., Kubasov, Alexey S., Selivanov, Nikita A., Lipengolts, Alexey A., Zhdanov, Andrey P., Bykov, Alexander Yu, Zhizhin, Konstantin Yu, Kuznetsov, Nikolai T.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18.06.2021; MDPI
• Subjects: Alcohol; Chloride; complexonates; contrast agent; Contrast agents; coordination chemistry; Crystal structure; Dichlorides; DTPA; Ethylenediamine; Hafnium; Ligands; Nitrilotriacetic acid; Salt; Salts; Single crystals; Sodium; structure elucidation; Toxicity; X-ray diffraction
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26123725

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.