Stability of the human faecal microbiome in a cohort of adult men

• Published in: Nature microbiology Vol. 3; no. 3; pp. 347 - 355
• Main Authors: Mehta, Raaj S., Abu-Ali, Galeb S., Drew, David A., Lloyd-Price, Jason, Subramanian, Ayshwarya, Lochhead, Paul, Joshi, Amit D., Ivey, Kerry L., Khalili, Hamed, Brown, Gordon T., DuLong, Casey, Song, Mingyang, Nguyen, Long H., Mallick, Himel, Rimm, Eric B., Izard, Jacques, Huttenhower, Curtis, Chan, Andrew T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Nature Publishing Group
• Subjects: 631/326/2565/2134; 631/326/2565/2142; 631/326/2565/855; 631/326/41/2532; 631/337/2019; Adult; Aged; Bacteria - classification; Biomedical and Life Sciences; Cohort Studies; Feces - microbiology; Follow-Up Studies; Gastrointestinal Microbiome; Gene Expression; Gene Expression Profiling; Health Personnel - statistics & numerical data; High-Throughput Nucleotide Sequencing; Humans; Infectious Diseases; Intestinal microflora; Life Sciences; Male; Medical Microbiology; Medical personnel; Metagenomics; Microbiology; Microbiomes; Microbiota; Middle Aged; Parasitology; Prospective Studies; Therapeutic applications; Variation; Virology

Characterizing the stability of the gut microbiome is important to exploit it as a therapeutic target and diagnostic biomarker. We metagenomically and metatranscriptomically sequenced the faecal microbiomes of 308 participants in the Health Professionals Follow-Up Study. Participants provided four s...