Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

• Published in: Journal of neuroimmune pharmacology Vol. 14; no. 1; pp. 110 - 119
• Main Authors: Ko, Allen, Kang, Guobin, Hattler, Julian B., Galadima, Hadiza I., Zhang, Junfeng, Li, Qingsheng, Kim, Woong-Ki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2019; Springer Nature B.V
• Subjects: Antiretroviral drugs; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Deoxyribonucleic acid; DNA; Drug therapy; Immunology; Neurosciences; Original; Original Article; Pharmacology/Toxicology; Virology; HIV-1; Brain; Reservoir; Antiretroviral therapy; HIV-associated neurocognitive disorders; Macrophage

The question of whether the human brain is an anatomical site of persistent HIV-1 infection during suppressive antiretroviral therapy (ART) is critical, but remains unanswered. The presence of virus in the brains of HIV patients whose viral load is effectively suppressed would demonstrate not only t...