Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 173; pp. 317 - 322
• Main Authors: Smith, Lynette M., Gallagher, J. Christopher, Suiter, Corinna
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2017
• Subjects: Accidental Falls - prevention & control; Aged; Cholecalciferol - administration & dosage; Cholecalciferol - blood; Cholecalciferol - therapeutic use; Clinical trial; Dietary Supplements - analysis; Double-Blind Method; Falls; Female; Humans; Middle Aged; Vitamin D - administration & dosage; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - therapeutic use; Vitamin D Deficiency - blood; Vitamin D Deficiency - drug therapy; Vitamin D supplementation; Vitamins - administration & dosage; Vitamins - blood; Vitamins - therapeutic use; Falls; Clinical trial; Vitamin D supplementation

•One year double blind trial, 7 daily oral doses of vitamin D or placebo, on incidence Fallers.•Faller rate was a U shaped curve, maximum decrease on doses 1600–3200 IU or serum 25OHD of 32–38ng/ml.•High vitamin D dose 4000–4800 IU increases Faller incidence in those with previous Fall history. Fall...