A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

• Published in: Clinical cancer research Vol. 23; no. 24; pp. 7621 - 7632
• Main Authors: Kreuzinger, Caroline, Geroldinger, Angelika, Smeets, Dominiek, Braicu, Elena Ioana, Sehouli, Jalid, Koller, Julia, Wolf, Andrea, Darb-Esfahani, Silvia, Joehrens, Korinna, Vergote, Ignace, Vanderstichele, Adriaan, Boeckx, Bram, Lambrechts, Diether, Gabra, Hani, Wisman, G Bea A, Trillsch, Fabian, Heinze, Georg, Horvat, Reinhard, Polterauer, Stephan, Berns, Els, Theillet, Charles, Cacsire Castillo-Tong, Dan
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 15.12.2017; American Association for Cancer Research
• Subjects: Adipose tissue; Adult; Aged; Antigen (tumor-associated); Antigens; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; B7 antigen; Cancer; Carcinoembryonic antigen; CD28 antigen; Cell Line, Tumor; Clustering; Complexity; Cystadenocarcinoma, Serous - genetics; Cystadenocarcinoma, Serous - immunology; Cystadenocarcinoma, Serous - pathology; Experimental design; Extracellular matrix; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene sequencing; Genes; Humans; Immune checkpoint; Immune response; Immune status; Immune system; Life Sciences; Medical treatment; Middle Aged; Molecular biology; Neoplasm Grading; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - immunology; Ovarian Neoplasms - pathology; Patients; Regulators; Ribonucleic acid; RNA; Sequence Analysis, RNA; Tissues; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumors

Most high-grade serous ovarian cancer (HGSOC) patients develop recurrent disease after first-line treatment, frequently with fatal outcome. This work aims at studying the molecular biology of both primary and recurrent HGSOC. Gene expression profiles of matched primary and recurrent fresh-frozen tum...