Plasma Levels of Transforming Growth Factor-β1 Reflect Left Ventricular Remodeling in Aortic Stenosis

• Published in: PloS one Vol. 4; no. 12; p. e8476
• Main Authors: Villar, Ana V., Cobo, Manuel, Llano, Miguel, Montalvo, Cecilia, González-Vílchez, Francisco, Martín-Durán, Rafael, Hurlé, María A., Nistal, J. Francisco
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 30.12.2009
• Subjects: Adaptation; Aorta; Aortic arch; Aortic stenosis; Apoptosis; Calcification; Cardiomyocytes; Cardiovascular disease; Cardiovascular Disorders; Cardiovascular Disorders/Heart Failure; Chains; Collagen; Cytokines; Diuretics; Enzyme-linked immunosorbent assay; Eutrophication; Extracellular matrix; Fibroblasts; Fibronectin; Fibrosis; Gender differences; Gene expression; Genes; Growth factors; Heart; Heart diseases; Heart failure; Hypertension; Hypertrophy; Kinases; Marfan syndrome; Men; Mice; Myosin; Paracrine signalling; Patients; Physiology/Cardiovascular Physiology and Circulation; Plasma levels; Plasmas (physics); Pressure; Rodents; Stenosis; Surgery; Transcription; Transforming growth factor; Transforming growth factor-b1; Ventricle; Womens health

Background TGF-β1 is involved in cardiac remodeling through an auto/paracrine mechanism. The contribution of TGF-β1 from plasmatic source to pressure overload myocardial remodeling has not been analyzed. We investigated, in patients with valvular aortic stenosis (AS), and in mice subjected to transv...