Cardiovascular and airway relaxant activities of peony root extract
Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to s...
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Published in | Canadian journal of physiology and pharmacology Vol. 86; no. 11; pp. 793 - 803 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Plattsburgh, NY
National Research Council of Canada
01.11.2008
NRC Research Press Canadian Science Publishing NRC Research Press |
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Abstract | Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to segments of guinea pig atria and trachea and rat aorta suspended separately in tissue baths. Activity against arachidonic acid (AA)-induced platelet aggregation was measured in human platelet-rich plasma. Airway relaxant effect was evaluated against acetylcholine (ACh)-induced airway contraction in mouse lung slices loaded with fluo-4. Pe.Cr (0.3-10 mg/mL) showed an atropine-resistant negative inotropic effect in atria. In rat aorta, an endothelium-independent vasodilatory effect (0.3-10 mg/mL) was seen in phenylephrine- and high-K
+
-induced contractions. Pe.Cr (0.01-1 mg/mL) also inhibited AA-induced platelet aggregation. In isolated trachea, Pe.Cr (0.3-10 mg/mL) relaxed carbachol- and histamine-induced contractions independently of β-adrenergic receptors. In mouse lung slices, Pe.Cr (0.3-1 mg/mL) inhibited ACh-induced airway narrowing and oscillations of intracellular Ca
2+
in airway smooth muscle cells. The results showed cardiosuppressant, vasodilatory, antiplatelet, and tracheal and airway relaxant activities of peony, providing potential justification for its medicinal use in different hyperactive cardiovascular and respiratory disorders. |
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AbstractList | Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to segments of guinea pig atria and trachea and rat aorta suspended separately in tissue baths. Activity against arachidonic acid (AA)-induced platelet aggregation was measured in human platelet-rich plasma. Airway relaxant effect was evaluated against acetylcholine (ACh)-induced airway contraction in mouse lung slices loaded with fluo-4. Pe.Cr (0.3-10 mg/mL) showed an atropine-resistant negative inotropic effect in atria. In rat aorta, an endothelium-independent vasodilatory effect (0.3-10 mg/mL) was seen in phenylephrine- and high-K
+
-induced contractions. Pe.Cr (0.01-1 mg/mL) also inhibited AA-induced platelet aggregation. In isolated trachea, Pe.Cr (0.3-10 mg/mL) relaxed carbachol- and histamine-induced contractions independently of β-adrenergic receptors. In mouse lung slices, Pe.Cr (0.3-1 mg/mL) inhibited ACh-induced airway narrowing and oscillations of intracellular Ca
2+
in airway smooth muscle cells. The results showed cardiosuppressant, vasodilatory, antiplatelet, and tracheal and airway relaxant activities of peony, providing potential justification for its medicinal use in different hyperactive cardiovascular and respiratory disorders. Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to segments of guinea pig atria and trachea and rat aorta suspended separately in tissue baths. Activity against arachidonic acid (AA)-induced platelet aggregation was measured in human platelet-rich plasma. Airway relaxant effect was evaluated against acetylcholine (ACh)-induced airway contraction in mouse lung slices loaded with fluo-4. Pe.Cr (0.3–10 mg/mL) showed an atropine-resistant negative inotropic effect in atria. In rat aorta, an endothelium-independent vasodilatory effect (0.3–10 mg/mL) was seen in phenylephrine- and high-K + -induced contractions. Pe.Cr (0.01–1 mg/mL) also inhibited AA-induced platelet aggregation. In isolated trachea, Pe.Cr (0.3–10 mg/mL) relaxed carbachol- and histamine-induced contractions independently of β-adrenergic receptors. In mouse lung slices, Pe.Cr (0.3–1 mg/mL) inhibited ACh-induced airway narrowing and oscillations of intracellular Ca 2+ in airway smooth muscle cells. The results showed cardiosuppressant, vasodilatory, antiplatelet, and tracheal and airway relaxant activities of peony, providing potential justification for its medicinal use in different hyperactive cardiovascular and respiratory disorders. Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to segments of guinea pig atria and trachea and rat aorta suspended separately in tissue baths. Activity against arachidonic acid (AA)-induced platelet aggregation was measured in human platelet-rich plasma. Airway relaxant effect was evaluated against acetylcholine (ACh)-induced airway contraction in mouse lung slices loaded with fluo-4. Pe.Cr (0.3-10 mg/mL) showed an atropine-resistant negative inotropic effect in atria. In rat aorta, an endothelium-independent vasodilatory effect (0.3-10 mg/mL) was seen in phenylephrine- and high-K+-induced contractions. Pe.Cr (0.01-1 mg/mL) also inhibited AA-induced platelet aggregation. In isolated trachea, Pe.Cr (0.3-10 mg/mL) relaxed carbachol- and histamine-induced contractions independently of beta-adrenergic receptors. In mouse lung slices, Pe.Cr (0.3-1 mg/mL) inhibited ACh-induced airway narrowing and oscillations of intracellular Ca2+ in airway smooth muscle cells. The results showed cardiosuppressant, vasodilatory, antiplatelet, and tracheal and airway relaxant activities of peony, providing potential justification for its medicinal use in different hyperactive cardiovascular and respiratory disorders. Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in the scientific literature examining its use in such conditions. We prepared a 70% ethanolic extract of peony root (Pe.Cr) and applied it to segments of guinea pig atria and trachea and rat aorta suspended separately in tissue baths. Activity against arachidonic acid (AA)-induced platelet aggregation was measured in human platelet-rich plasma. Airway relaxant effect was evaluated against acetylcholine (ACh)-induced airway contraction in mouse lung slices loaded with fluo-4. Pe.Cr (0.3-10 mg/mL) showed an atropine-resistant negative inotropic effect in atria. In rat aorta, an endothelium-independent vasodilatory effect (0.3-10 mg/mL) was seen in phenylephrine- and high-[K.sup.+]induced contractions. Pe.Cr (0.01-1 mg/mL) also inhibited AA-induced platelet aggregation. In isolated trachea, Pe.Cr (0.3-10 mg/mL) relaxed carbachol- and histamine-induced contractions independently of β-adrenergic receptors. In mouse lung slices, Pe.Cr (0.3-1 mg/mL) inhibited ACh-induced airway narrowing and oscillations of intracellular [Ca.sup.2+] in airway smooth muscle cells. The results showed cardiosuppressant, vasodilatory, antiplatelet, and tracheal and airway relaxant activities of peony, providing potential justification for its medicinal use in different hyperactive cardiovascular and respiratory disorders. |
Abstract_FL | Paeonia emodi, aussi appelée pivoine de l'Himalaya, est une plante médicinale bien connue utilisée pour traiter l'hypertension, les palpitations et l'asthme. Malgré sa popularité, il existe peu d'articles justifiant son utilisation dans de telles situations pathologiques, d'où l'intérêt de la présente étude. On a préparé un extrait éthanolique à 70 % (Pe.Cr) de racines de pivoine. On a suspendu séparément des segments d'oreillettes et de trachées de cobayes et des segments d'aortes de rats dans des bains de tissus. On a mesuré l'activité contre l'agrégation induite par l'acide arachidonique (AA) dans du plasma riche en plaquettes humaines. On a évalué l'effet relaxant sur la contraction bronchique induite par l'acétylcholine (ACh) dans des tranches de poumons murins chargées avec du fluo-4. Pe.Cr (0,3-10 mg/mL) a montré un effet inotrope négatif résistant à l'atropine dans les oreillettes. Dans l'aorte, un effet vasodilatateur indépendant de l'endothélium (0,3-10 mg/mL) a été observé sur les contractions induites par la phényléphrine et par un haut taux de K
+
. Pe.Cr (0,01-1 mg/mL) a aussi inhibé l'agrégation des plaquettes induite par l'AA. Dans la trachée isolée, Pe.Cr (0,3-10 mg/mL) a relaxé les contractions induites par le carbachol et l'histamine, indépendamment des récepteurs β-adrénergiques. Dans les tranches de poumons de souris, Pe.Cr (0,3-1 mg/mL) a inhibé le rétrécissement des voies aériennes induit par l'ACh et les oscillations du Ca
2+
dans les cellules musculaires lisses bronchiques. Ces résultats montrent que la pivoine a des activités cardio-inhibitrices, vasodilatatrices, antiplaquettaires et relaxantes dans la trachée et les voies aériennes. Ces observations justifient le potentiel de cette plante médicinale pour traiter différents troubles respiratoires et cardiovasculaires. |
Audience | Academic |
Author | Ismail, Muhammad Iqbal, Zafar Ghayur, Muhammad N Saeed, Sheikh A Khan, Abdullah Janssen, Luke J Gilani, Anwarul H Rasheed, Huma |
Author_xml | – sequence: 1 givenname: Muhammad N surname: Ghayur fullname: Ghayur, Muhammad N email: nghayur@mcmaster.ca organization: Department of Medicine, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada – sequence: 2 givenname: Anwarul H surname: Gilani fullname: Gilani, Anwarul H organization: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan – sequence: 3 givenname: Huma surname: Rasheed fullname: Rasheed, Huma organization: Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan – sequence: 4 givenname: Abdullah surname: Khan fullname: Khan, Abdullah organization: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan – sequence: 5 givenname: Zafar surname: Iqbal fullname: Iqbal, Zafar organization: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan – sequence: 6 givenname: Muhammad surname: Ismail fullname: Ismail, Muhammad organization: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan – sequence: 7 givenname: Sheikh A surname: Saeed fullname: Saeed, Sheikh A organization: Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan – sequence: 8 givenname: Luke J surname: Janssen fullname: Janssen, Luke J organization: Department of Medicine, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada |
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Cites_doi | 10.1016/j.lfs.2003.06.039 10.1007/BF02969283 10.1007/BF02993965 10.1161/01.RES.82.12.1323 10.1111/j.1476-5381.1959.tb00928.x 10.1085/jgp.119.2.187 10.1085/jgp.200409216 10.1139/Y08-030 10.1248/cpb.48.1771 10.1073/pnas.72.8.2994 10.1006/phrs.1997.0195 10.1515/znb-1999-0419 10.1152/ajplung.00130.2004 10.1016/j.phytochem.2003.10.012 10.1042/cs0770099 10.1097/00005344-200501000-00013 10.1080/14756360400026220 10.1080/1057563021000060103 10.1183/09031936.00025907 10.1146/annurev.ph.48.030186.001515 10.1186/1465-9921-7-123 10.3923/pjbs.2003.984.986 10.1038/288373a0 10.3923/ijp.2006.33.41 10.1248/cpb.51.252 |
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Snippet | Paeonia emodi (peony) is a well known plant used medicinally to treat hypertension, palpitations, and asthma. Despite its popularity, there are few reports in... |
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SubjectTerms | agrégation des plaquettes Animals Aorta, Thoracic - drug effects aorte de rat avec endothélium intact Arachidonic Acids - pharmacology Biological and medical sciences Calcium Signaling - drug effects Cardiovascular diseases Care and treatment Chemical properties confocal microscopy Coronary vessels endothelium-intact rat aorta Ethanol Female Flowers & plants fluorescence fluorescence du Ca Fundamental and applied biological sciences. Psychology guinea pig atria Guinea Pigs Health aspects Heart Atria Herbal medicine Image Processing, Computer-Assisted In Vitro Techniques Lung - drug effects Male Materia medica, Vegetable microscopie confocale Microscopy, Confocal mouse lung slices Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth, Vascular - drug effects oreillette de cobaye Paeonia - chemistry Paeonia emodi Peonies Plant extracts Plant Extracts - pharmacology platelet aggregation Platelet Aggregation - drug effects Rats Rats, Sprague-Dawley Solvents Studies Trachea - drug effects tranches de poumon de souris Vasodilator Agents - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
Title | Cardiovascular and airway relaxant activities of peony root extract |
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