Targeting the inflammasome in Parkinson’s disease

• Published in: Frontiers in aging neuroscience Vol. 14; p. 957705
• Main Authors: Su, Qi, Ng, Wei Lun, Goh, Suh Yee, Gulam, Muhammad Yaaseen, Wang, Lin-Fa, Tan, Eng-King, Ahn, Matae, Chao, Yin-Xia
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 12.10.2022; Frontiers Media S.A
• Subjects: Apoptosis; Brain; Cytokines; Dopamine; inflammasome; Inflammasomes; Inflammation; inhibitor; Kinases; Movement disorders; Mutation; Neurodegeneration; Neurodegenerative diseases; neuroinflammation; Neurons; Neuroscience; NLRP3; Orthostatic hypotension; Parkinson's disease; Pathogenesis; Proteins; Synuclein; Tumor necrosis factor-TNF

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relatio...