Targeting the inflammasome in Parkinson’s disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relatio...

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Published inFrontiers in aging neuroscience Vol. 14; p. 957705
Main Authors Su, Qi, Ng, Wei Lun, Goh, Suh Yee, Gulam, Muhammad Yaaseen, Wang, Lin-Fa, Tan, Eng-King, Ahn, Matae, Chao, Yin-Xia
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 12.10.2022
Frontiers Media S.A
Subjects
Apoptosis
Brain
Cytokines
Dopamine
inflammasome
Inflammasomes
Inflammation
inhibitor
Kinases
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
neuroinflammation
Neurons
Neuroscience
NLRP3
Orthostatic hypotension
Parkinson's disease
Pathogenesis
Proteins
Synuclein
Tumor necrosis factor-TNF
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Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential in vitro and in vivo models that are available for therapeutic discovery and development.
AbstractList Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential in vitro and in vivo models that are available for therapeutic discovery and development.
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential in vitro and in vivo models that are available for therapeutic discovery and development.
Author Ng, Wei Lun
Chao, Yin-Xia
Tan, Eng-King
Ahn, Matae
Gulam, Muhammad Yaaseen
Su, Qi
Goh, Suh Yee
Wang, Lin-Fa
AuthorAffiliation 2 Department of Neurology, Singapore General Hospital , Singapore , Singapore
4 Neuroscience and Behavioural Disorders Program, Duke–NUS Medical School , Singapore , Singapore
1 Programme in Emerging Infectious Diseases, Duke–NUS Medical School , Singapore , Singapore
3 Department of Research, National Neuroscience Institute , Singapore , Singapore
AuthorAffiliation_xml – name: 1 Programme in Emerging Infectious Diseases, Duke–NUS Medical School , Singapore , Singapore
– name: 4 Neuroscience and Behavioural Disorders Program, Duke–NUS Medical School , Singapore , Singapore
– name: 2 Department of Neurology, Singapore General Hospital , Singapore , Singapore
– name: 3 Department of Research, National Neuroscience Institute , Singapore , Singapore
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Copyright © 2022 Su, Ng, Goh, Gulam, Wang, Tan, Ahn and Chao. 2022 Su, Ng, Goh, Gulam, Wang, Tan, Ahn and Chao
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– notice: Copyright © 2022 Su, Ng, Goh, Gulam, Wang, Tan, Ahn and Chao. 2022 Su, Ng, Goh, Gulam, Wang, Tan, Ahn and Chao
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This article was submitted to Parkinson’s Disease and Aging-related Movement Disorders, a section of the journal Frontiers in Aging Neuroscience
These authors have contributed equally to this work
Reviewed by: Yogesh Singh, University of Tübingen, Germany
Edited by: Kunlin Jin, University of North Texas Health Science Center, United States
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Snippet Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of...
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SubjectTerms Apoptosis
Brain
Cytokines
Dopamine
inflammasome
Inflammasomes
Inflammation
inhibitor
Kinases
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
neuroinflammation
Neurons
Neuroscience
NLRP3
Orthostatic hypotension
Parkinson's disease
Pathogenesis
Proteins
Synuclein
Tumor necrosis factor-TNF
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Title Targeting the inflammasome in Parkinson’s disease
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