Do Statins Impair Cognition? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Published in: Journal of general internal medicine : JGIM Vol. 30; no. 3; pp. 348 - 358
• Main Authors: Ott, Brian R., Daiello, Lori A., Dahabreh, Issa J., Springate, Beth A., Bixby, Kimberly, Murali, Manjari, Trikalinos, Thomas A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2015; Springer Nature B.V
• Subjects: Clinical trials; Cognition & reasoning; Cognition Disorders - chemically induced; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Internal Medicine; Medicine; Medicine & Public Health; Neuropsychological Tests - standards; Randomized Controlled Trials as Topic - standards; Review; Statins; Systematic review; meta-analysis; cognition; systematic review; randomized control trials; statins

ABSTRACT BACKGROUND In 2012, the United States Food and Drug Administration (FDA) issued a warning regarding potential adverse effects of HMG-CoA reductase inhibitors (statins) on cognition, based on the Adverse Events Reporting System and a review of the medical literature. We aimed to synthesize r...