Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes

• Published in: Frontiers in neuroscience Vol. 15; p. 768262
• Main Authors: Wang, Xuankang, Zhang, Zhihao, Zhu, Zhijie, Liang, Zhuowen, Zuo, Xiaoshuang, Ju, Cheng, Song, Zhiwen, Li, Xin, Hu, Xueyu, Wang, Zhe
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 02.11.2021; Frontiers Media S.A
• Subjects: A1/A2 astrocytes; Antibodies; Astrocytes; basic fibroblast growth factor; Compression; Dorsal root ganglia; Fibroblast growth factors; Genetic transformation; Growth factors; Immune system; Inflammation; Lasers; Neuroprotection; Neuroscience; Neurotoxicity; Phenotypes; photobiomodulation; Spinal cord injuries; spinal cord injury; Transforming growth factor-b; transforming growth factor-β; China

After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) can promote motor function recovery...