Structure-Based Bioisosterism Design, Synthesis, Biological Activity and Toxicity of 1,2,4-Oxadiazole Substituted Benzamides Analogues Containing Pyrazole Rings

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 15; p. 4692
• Main Authors: Tu, Min-Ting, Shao, Ying-Ying, Yang, Sen, Sun, Bin-Long, Wang, Ying-Ying, Tan, Cheng-Xia, Wang, Xue-Dong
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.07.2022; MDPI
• Subjects: 1,2,4-oxadiazole; Antifungal agents; benzamide compounds; biological activity; Chromatography; Embryos; Ethanol; Hydrocarbons; Mortality; pyrazole; Solvents; synthesis

In order to discover pesticidal lead compounds with high activity and low toxicity, a series of novel benzamides substituted with pyrazole-linked 1,2,4-oxadiazole were designed via bioisosterism. The chemical structures of the target compounds were confirmed via 1H NMR, 13C NMR and HRMS analysis. Th...