Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 17; p. 5724
• Main Authors: Xiao, Mengjie, Cao, Fei, Huang, Tao, Tang, Yun-Sang, Zhao, Xin, Shaw, Pang-Chui
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 05.09.2022; MDPI
• Subjects: Binding sites; Bioassays; Canarium album (Lour.) DC; Cytokines; Edema; Infections; Influenza; influenza virus; Lungs; NA inhibitor; Pathology; Phytochemicals; Hong Kong China; California; United States > US; China

Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus. To find and characterize anti-influenza virus phytochemicals from GLY, we performed (1) bioassay-guided i...