Kaempferol: Paving the path for advanced treatments in aging-related diseases
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical p...
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| Published in | Experimental gerontology Vol. 188; p. 112389 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Inc
01.04.2024
Elsevier |
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| Abstract | Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) and modulates crucial cellular pathways, thereby combating oxidative stress and inflammation, hallmarks of ARDs. Kaempferol's low toxicity and wide safety margins, as demonstrated by preclinical and clinical studies, further substantiate its therapeutic potential. Compelling evidence supports Kaempferol's substantial potential in addressing ARDs through several mechanisms, notably anti-inflammatory, antioxidant, and anti-apoptotic actions. Kaempferol exhibits a versatile neuroprotective effect by modulating various proinflammatory signaling pathways, including NF-kB, p38MAPK, AKT, and the β-catenin cascade. Additionally, it hinders the formation and aggregation of beta-amyloid protein and regulates brain-derived neurotrophic factors. In terms of its anticancer potential, kaempferol acts through diverse pathways, inducing apoptosis, arresting the cell cycle at the G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, and affecting the phosphoinositide 3-kinase/protein kinase B signaling pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, and conducting comprehensive clinical trials to translate these findings into effective therapeutic applications.
•ARDs major global health issue, need for therapies•Kaempferol promising for ARDs, found in plants•Kaempferol has antioxidative, anti-inflammatory structure.•Counters ROS, fights ARD oxidative stress and inflammation•Low toxicity, safe per studies, good for ARD therapy |
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| AbstractList | Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) and modulates crucial cellular pathways, thereby combating oxidative stress and inflammation, hallmarks of ARDs. Kaempferol's low toxicity and wide safety margins, as demonstrated by preclinical and clinical studies, further substantiate its therapeutic potential. Compelling evidence supports Kaempferol's substantial potential in addressing ARDs through several mechanisms, notably anti-inflammatory, antioxidant, and anti-apoptotic actions. Kaempferol exhibits a versatile neuroprotective effect by modulating various proinflammatory signaling pathways, including NF-kB, p38MAPK, AKT, and the β-catenin cascade. Additionally, it hinders the formation and aggregation of beta-amyloid protein and regulates brain-derived neurotrophic factors. In terms of its anticancer potential, kaempferol acts through diverse pathways, inducing apoptosis, arresting the cell cycle at the G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, and affecting the phosphoinositide 3-kinase/protein kinase B signaling pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, and conducting comprehensive clinical trials to translate these findings into effective therapeutic applications.Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) and modulates crucial cellular pathways, thereby combating oxidative stress and inflammation, hallmarks of ARDs. Kaempferol's low toxicity and wide safety margins, as demonstrated by preclinical and clinical studies, further substantiate its therapeutic potential. Compelling evidence supports Kaempferol's substantial potential in addressing ARDs through several mechanisms, notably anti-inflammatory, antioxidant, and anti-apoptotic actions. Kaempferol exhibits a versatile neuroprotective effect by modulating various proinflammatory signaling pathways, including NF-kB, p38MAPK, AKT, and the β-catenin cascade. Additionally, it hinders the formation and aggregation of beta-amyloid protein and regulates brain-derived neurotrophic factors. In terms of its anticancer potential, kaempferol acts through diverse pathways, inducing apoptosis, arresting the cell cycle at the G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, and affecting the phosphoinositide 3-kinase/protein kinase B signaling pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, and conducting comprehensive clinical trials to translate these findings into effective therapeutic applications. Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) and modulates crucial cellular pathways, thereby combating oxidative stress and inflammation, hallmarks of ARDs. Kaempferol's low toxicity and wide safety margins, as demonstrated by preclinical and clinical studies, further substantiate its therapeutic potential. Compelling evidence supports Kaempferol's substantial potential in addressing ARDs through several mechanisms, notably anti-inflammatory, antioxidant, and anti-apoptotic actions. Kaempferol exhibits a versatile neuroprotective effect by modulating various proinflammatory signaling pathways, including NF-kB, p38MAPK, AKT, and the β-catenin cascade. Additionally, it hinders the formation and aggregation of beta-amyloid protein and regulates brain-derived neurotrophic factors. In terms of its anticancer potential, kaempferol acts through diverse pathways, inducing apoptosis, arresting the cell cycle at the G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, and affecting the phosphoinositide 3-kinase/protein kinase B signaling pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, and conducting comprehensive clinical trials to translate these findings into effective therapeutic applications. Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) and modulates crucial cellular pathways, thereby combating oxidative stress and inflammation, hallmarks of ARDs. Kaempferol's low toxicity and wide safety margins, as demonstrated by preclinical and clinical studies, further substantiate its therapeutic potential. Compelling evidence supports Kaempferol's substantial potential in addressing ARDs through several mechanisms, notably anti-inflammatory, antioxidant, and anti-apoptotic actions. Kaempferol exhibits a versatile neuroprotective effect by modulating various proinflammatory signaling pathways, including NF-kB, p38MAPK, AKT, and the β-catenin cascade. Additionally, it hinders the formation and aggregation of beta-amyloid protein and regulates brain-derived neurotrophic factors. In terms of its anticancer potential, kaempferol acts through diverse pathways, inducing apoptosis, arresting the cell cycle at the G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, and affecting the phosphoinositide 3-kinase/protein kinase B signaling pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, and conducting comprehensive clinical trials to translate these findings into effective therapeutic applications. •ARDs major global health issue, need for therapies•Kaempferol promising for ARDs, found in plants•Kaempferol has antioxidative, anti-inflammatory structure.•Counters ROS, fights ARD oxidative stress and inflammation•Low toxicity, safe per studies, good for ARD therapy |
| ArticleNumber | 112389 |
| Author | Wong, Ling Shing Almalki, Waleed Hassan Kazmi, Imran Shahwan, Moyad Kukreti, Neelima Kumarasamy, Vinoth Altamimi, Abdulmalik Saleh Alfawaz Alzarea, Sami I. Gupta, Gaurav Subramaniyan, Vetriselvan Hussain, Md Sadique Afzal, Muhammad |
| Author_xml | – sequence: 1 givenname: Md Sadique surname: Hussain fullname: Hussain, Md Sadique organization: School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017 Jaipur, Rajasthan, India – sequence: 2 givenname: Abdulmalik Saleh Alfawaz surname: Altamimi fullname: Altamimi, Abdulmalik Saleh Alfawaz organization: Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia – sequence: 3 givenname: Muhammad surname: Afzal fullname: Afzal, Muhammad organization: Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia – sequence: 4 givenname: Waleed Hassan surname: Almalki fullname: Almalki, Waleed Hassan organization: Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia – sequence: 5 givenname: Imran surname: Kazmi fullname: Kazmi, Imran organization: Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia – sequence: 6 givenname: Sami I. surname: Alzarea fullname: Alzarea, Sami I. organization: Department of Pharmacology, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia – sequence: 7 givenname: Gaurav surname: Gupta fullname: Gupta, Gaurav organization: Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India – sequence: 8 givenname: Moyad surname: Shahwan fullname: Shahwan, Moyad organization: Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, Ajman 346, United Arab Emirates – sequence: 9 givenname: Neelima surname: Kukreti fullname: Kukreti, Neelima organization: School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India – sequence: 10 givenname: Ling Shing surname: Wong fullname: Wong, Ling Shing organization: Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia – sequence: 11 givenname: Vinoth surname: Kumarasamy fullname: Kumarasamy, Vinoth email: vinoth@ukm.edu.my organization: Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia – sequence: 12 givenname: Vetriselvan surname: Subramaniyan fullname: Subramaniyan, Vetriselvan email: subramaniyan.vetriselvan@monash.edu organization: Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38432575$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s13311-020-00853-2 10.2337/dci17-0005 10.2174/1570159X17666190801155922 10.1002/(SICI)1520-6866(1996)16:4<229::AID-TCM4>3.0.CO;2-K 10.1021/jf9902651 10.1016/j.pharep.2017.05.002 10.1016/j.phymed.2020.153235 10.1167/iovs.16-20312 10.1167/iovs.18-23893 10.1017/S000711450999170X 10.1021/jf9811065 10.1002/iid3.163 10.1016/j.cell.2013.03.030 10.1016/j.jmb.2019.09.016 10.3390/molecules25184073 10.1186/ar3687 10.1007/s10787-017-0416-2 10.3390/molecules201018031 10.3390/ijms18051001 10.1111/jcmm.12186 10.1016/j.foodchem.2012.11.139 10.1002/bmc.4736 10.1038/nm.4324 10.1155/2022/8383315 10.1016/j.biopha.2017.05.075 10.1007/s11011-019-0389-5 10.1093/cvr/cvab161 10.1902/jop.2012.120180 10.1111/jfbc.14305 10.1016/j.ejmech.2014.08.011 10.3390/biom8040124 10.1007/s00335-015-9568-9 10.4155/fmc-2021-0127 10.1111/j.1474-9726.2010.00660.x 10.1055/a-1345-9528 10.2174/1573401318666220527124759 10.1161/01.RES.0000233315.38086.bc 10.1016/j.neulet.2019.134633 10.2174/1389200024605082 10.1016/j.pneurobio.2011.04.013 10.3892/ijmm.2013.1468 10.1038/s41392-021-00765-3 10.1042/bj2480953 10.1016/j.biomag.2013.05.004 10.1167/iovs.13-11612 10.3389/fphar.2022.1046523 10.1016/j.jchromb.2017.05.018 10.1007/BF02406145 10.1111/j.1365-2621.1976.tb00743.x 10.1016/j.prp.2023.154850 10.1016/j.freeradbiomed.2010.09.006 10.1016/j.jff.2020.104041 10.1002/neu.480250807 10.2174/1871527317666180508123050 10.2337/db20-0553 10.1007/s10522-015-9596-6 10.1039/D2FO02688K 10.3892/ijmm.2021.4941 10.1055/s-0043-103415 10.1016/j.cmet.2013.03.009 10.4314/tjpr.v19i3.28 10.3390/nu12020538 10.14336/AD.2017.0103 10.1016/j.fct.2009.06.005 10.1021/jf00024a011 10.1038/nature17172 10.1093/abbs/gmy002 10.3390/genes8120398 10.1016/j.jep.2016.05.014 10.1161/ATVBAHA.120.314333 10.1002/art.21639 10.1002/jbmr.2892 10.1186/s12974-021-02088-0 10.1161/CIRCRESAHA.111.261388 10.1016/j.bbadis.2017.06.011 10.1093/ajcn/80.1.15 10.1080/1071576021000016463 10.1016/j.jss.2018.08.009 10.18632/aging.101469 10.1007/s002030050010 10.1172/JCI44303 10.1179/1351000214Y.0000000117 10.5603/cd.97473 10.1038/s41572-021-00269-y 10.3389/fnut.2021.688086 10.2119/molmed.2009.00162 10.1186/s12974-019-1654-6 10.3897/pharmacia.69.e87013 10.1016/j.brainres.2019.146361 10.5603/cd.97294 10.1055/s-0033-1350808 10.1016/S0014-5793(97)00467-5 10.3390/molecules27196164 10.1159/000122962 10.1016/j.fitote.2010.06.028 10.1016/j.freeradbiomed.2021.05.013 10.1016/j.mrfmmm.2014.12.011 10.1210/endo-103-5-1860 10.1021/np9904509 10.1038/nature05529 10.1615/JEnvironPatholToxicolOncol.2018027246 10.1038/sj.ejcn.1601916 10.1155/2018/1610751 10.3390/molecules25204649 10.1093/carcin/10.10.1953 10.1186/s12885-021-08158-z 10.1155/2022/8878923 10.1007/s00394-007-0670-y 10.1155/2013/485201 10.1152/ajpgi.00223.2002 10.3389/fncel.2014.00373 10.3389/fendo.2020.00280 10.1093/mutage/12.5.383 10.3390/nu11102288 10.2174/138955711795305335 10.1002/jbmr.1851 10.1038/nrd1693 10.1080/00207454.2019.1653867 10.1038/nm.4385 10.1111/acel.13657 10.3390/ijms22052245 10.1155/2015/904142 10.1016/j.intimp.2012.07.007 10.3390/ijms222413384 10.1615/JEnvironPatholToxicolOncol.2022042088 10.1007/s11033-022-07863-7 10.1016/j.gendis.2021.02.009 10.1615/IntJMedMushrooms.2019030351 10.1016/j.atherosclerosis.2014.03.019 10.1039/C5FO01258A 10.2217/rme-2023-0077 10.1080/10408398.2021.1980762 10.1161/CIRCRESAHA.120.318353 10.1155/2022/2273000 10.1039/c4fo00068d 10.1001/jamapediatrics.2015.0439 10.1016/j.jep.2012.03.013 10.1007/s11356-022-20240-y 10.1038/nn.3786 10.1002/ptr.6300 10.1155/2022/6741995 10.1371/journal.pone.0032673 10.1016/j.mad.2013.07.002 10.1096/fasebj.31.1_supplement.681.7 10.1073/pnas.89.10.4668 10.1161/CIRCRESAHA.120.317348 10.3390/molecules20034813 10.3390/ijms22010217 10.1016/j.foodres.2017.10.010 10.1016/j.lfs.2005.04.072 10.1007/s12020-018-1525-4 10.1126/science.abb5916 10.2174/1573401319666221226144613 10.3390/ijms24108630 10.3390/nu11030572 10.1038/s41586-020-1984-7 10.2147/DDDT.S315060 10.1016/S0300-483X(02)00198-1 10.3390/ijms21072358 10.1186/s12979-017-0108-1 10.1016/j.fct.2017.05.043 10.1016/j.bmc.2015.12.021 10.1159/000524942 10.1056/NEJMc1305541 10.2147/DDDT.S304911 10.1002/biof.2009 10.1002/fsn3.3499 10.1016/0304-3835(96)04251-6 10.3389/fphar.2022.967164 10.1042/BJ20040990 10.1016/j.phymed.2015.09.003 10.3390/nu15163578 10.15585/mmwr.mm6609e1 10.1007/s40520-019-01359-4 10.3390/cells12121568 10.1038/s41571-022-00668-4 10.18632/aging.101820 10.1016/j.ejphar.2011.08.011 10.1080/09637480601154228 10.1016/j.ejphar.2006.11.014 10.1002/bdd.677 10.1158/2159-8290.CD-16-0217 10.1155/2013/104308 10.1248/bpb.34.1291 10.1016/j.ceca.2020.102282 10.3389/fphar.2021.739326 10.1111/j.1745-4565.1983.tb00455.x 10.1097/01.blo.0000143818.74887.b1 10.1016/j.bbrep.2021.100920 10.1097/MD.0000000000032059 10.1002/jbt.23482 10.1089/jop.2022.0128 10.1007/BF03190482 10.1161/CIRCRESAHA.111.300543 10.1002/mnfr.200500144 10.1074/jbc.M606804200 10.1002/wnan.1840 10.1155/2019/8748253 10.1038/nrneurol.2010.178 10.3389/fcell.2021.656201 10.1016/j.bbadis.2018.08.008 10.1016/j.jff.2020.104140 10.1039/C0FO00106F 10.3389/fonc.2023.1169168 10.1124/pr.115.010652 10.1038/s41531-022-00347-2 10.1210/jc.2014-1222 10.3389/fphys.2018.01798 10.1016/B978-0-444-52899-5.00025-3 10.1007/s00125-019-4934-x 10.1093/cvr/cvac013 10.1167/iovs.16-19727 10.1007/s11357-009-9124-1 10.1016/j.jchromb.2009.08.046 10.1021/jf402838a 10.1016/j.lfs.2007.12.021 10.21037/apm-21-1691 10.2174/1871529X21666210812111931 10.1007/s00204-007-0215-4 10.2174/1573409919666230112123213 10.1007/s12272-009-1127-z 10.1172/jci.insight.120157 10.2174/138920009787846369 10.1038/s41598-018-20499-7 10.1016/0165-1161(78)90020-1 10.1155/2013/250725 10.1016/j.pneurobio.2022.102270 10.1016/j.ijbiomac.2021.09.115 10.2174/1568026622666220907112822 10.12659/MSM.902491 10.3390/ijms23137461 10.1021/jf000892m 10.15252/embj.2018100492 10.1111/j.1476-5381.2011.01389.x 10.1111/j.1474-9726.2007.00350.x 10.3233/JAD-161221 10.1021/jf9029942 10.1124/pr.58.2.3 10.1016/j.intimp.2018.01.002 10.3390/ijms232315054 10.5603/DK.a2023.0015 10.1002/ptr.4648 10.1038/tp.2017.165 10.1172/JCI95147 10.4103/1673-5374.238714 10.3390/molecules27154952 10.1186/ar2592 10.1248/bpb.26.1120 10.1210/endocr/bqz028 10.1016/j.freeradbiomed.2004.01.002 10.1021/jf0612981 10.1002/(SICI)1097-4547(19990801)57:3<399::AID-JNR12>3.0.CO;2-W 10.3390/ijms11020595 10.1016/j.exger.2014.07.003 10.1038/s41401-019-0279-8 10.1080/15548627.2019.1596481 10.3390/molecules23071751 10.1186/1476-511X-12-115 10.1016/0165-1218(89)90114-6 10.1002/art.38641 10.1016/j.prp.2023.154738 10.1016/j.cbi.2022.110135 10.1016/j.mad.2018.10.005 10.14740/jem884 10.1016/j.prp.2023.154773 10.3390/ijms20081844 10.1002/cbdv.201800129 10.1021/jf073444o 10.1155/2013/162750 10.1007/s00018-019-03420-x 10.1248/bpb.32.489 10.1016/j.taap.2005.04.004 10.1111/j.1365-2621.1989.tb05143.x 10.1016/j.cell.2013.05.039 10.3390/ijms232415747 10.1007/s13105-016-0479-3 10.3390/ijms23031058 10.1186/1423-0127-19-104 10.1038/s41598-020-59244-4 10.1016/j.cbi.2022.109842 10.1093/geroni/igab046.1440 10.1007/s13580-015-0114-1 10.1038/s41568-022-00450-9 |
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| Keywords | Aging-related disorders Antioxidant Kaempferol Toxicity Therapeutic implications Flavonoid |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. |
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| References | Bokkenheuser, Shackleton, Winter (bb0130) 1987; 248 Zhao, Zhang, Xia, Shi, Wang, Zheng, Hu, Zhang (bb1565) 2014; 18 Gandhi, Mahant, Sharma, Kumar, Dua, Chellappan, Singh, Gupta, Aljabali, Tambuwala, Kapoor (bb0400) 2023 de la Garza, Garza-Cuellar, Silva-Hernandez, Cardenas-Perez, Reyes-Castro, Zambrano, Gonzalez-Hernandez, Garza-Ocañas, Fuentes-Mera, Camacho (bb0275) 2019; 11 Wang, Bennett (bb1385) 2012; 111 Xie, Zeng, Liao, Zhou, Wu, Xu (bb1450) 2021; 12 Hussain, Afzal, Gupta, Altamimi, Almalki, Alzarea, Kazmi, Kukreti, Gupta, Sulakhiya, Singh, Dua (bb0585) 2023; 249 Stilling, Benito, Gertig, Barth, Capece, Burkhardt, Bonn, Fischer (bb1280) 2014; 8 Zarei, Mohammadi, Jabbari, Shahidi (bb1515) 2019; 129 Georgiadou, Rutter (bb0430) 2020; 91 Vezzani, French, Bartfai, Baram (bb1365) 2011; 7 Brozovich, Nicholson, Degen, Gao, Aggarwal, Morgan (bb0145) 2016; 68 Wang, Yao, Zeng (bb1390) 2003; 28 Bahl, Hussain, Saraswat, Agrawal (bb0070) 2023; 12 Al-Numair, Chandramohan, Veeramani, Alsaif (bb0045) 2015; 20 Cortes (bb0240) 2021; 5 Sengupta, Biswas, Roy, Lovett, Simington, Fry, Travis (bb1205) 2022; 22 Montero, Lobatón, Hernández-Sanmiguel, Santodomingo, Vay, Moreno, Alvarez (bb0980) 2004; 384 Hua, Li, Zhang, Zhou, Wang, Ling, Bao (bb0545) 2022; 46 Blasiak (bb0125) 2020; 77 Martin, Horwitz, Ryan, McGuire (bb0925) 1978; 103 Han, Sun, Sun, Song, Zhu, Song, Chen, Sun, Xia, Ding, Lu, Yao, Hu (bb0490) 2019; 15 Rim, Nam, Ju (bb1125) 2020; 21 Boyang, Yuexing, Yiping, Haiyang, Lingjie, Liancheng, Xufei, Jie, Yunzhi (bb0140) 2022; 101 López-Otín, Blasco, Partridge, Serrano, Kroemer (bb0875) 2013; 153 Manach, Morand, Demigné, Texier, Régérat, Rémésy (bb0915) 1997; 409 Weissman, Maack (bb1405) 2021; 171 Midha, Pan, Abarca, Andle, Carapeto, Bonner-Weir, Aguayo-Mazzucato (bb0955) 2021; 70 Gao, Wang, Peng, Deng (bb0405) 2019; 34 de Yébenes, Briones, Martos-Folgado, Mur, Oller, Bilal, González-Amor, Méndez-Barbero, Silla-Castro, Were, Jiménez-Borreguero, Sánchez-Cabo, Bueno, Salaices, Redondo, Ramiro (bb0280) 2020; 40 Wang, Lankhorst, Bernards (bb1400) 2022; 22 Wiciński, Erdmann, Nowacka, Kuźmiński, Michalak, Janowski, Ohla, Biernaciak, Szambelan, Zabrzyński (bb1415) 2023; 15 Blanco-Salas, Vazquez, Hortigón-Vinagre, Ruiz-Tellez (bb0120) 2019; 8 Kouhestani, Jafari, Babaei (bb0725) 2018; 13 Kumar, Pandey (bb0745) 2013; 2013 Castejón, Montoya, Alarcón-de-la-Lastra, Sánchez-Hidalgo (bb0170) 2020; 9 Barve, Chen, Hebbar, Desiderio, Saw, Kong (bb0090) 2009; 30 Huang, Wen, Wang, Xu, Zhou, Li (bb0550) 2020; 34 Xu, Zhao, Peng, Xie, Liu (bb1460) 2017; 50 Kadioglu, Nass, Saeed, Schuler, Efferth (bb0665) 2015; 35 Holder, Churchwell, Doerge (bb0530) 1999; 47 Tuñón, García-Mediavilla, Sánchez-Campos, González-Gallego (bb1355) 2009; 10 Abdullah, Ravanan (bb0010) 2018; 8 DuPont, Day, Bennett, Mellon, Kroon (bb0305) 2004; 58 Farlow, Miller, Pejovic (bb0325) 2008; 25 Sharoar, Thapa, Shahnawaz, Ramasamy, Woo, Shin, Park (bb1235) 2012; 19 Yu, Chen, Wang, Kuang, Liu, Zhang, Du (bb1505) 2013; 8 Häkkinen, Kärenlampi, Heinonen, Mykkänen, Törrönen (bb0480) 1999; 47 Park, Sapkota, Kim, Kim, Kim (bb1050) 2011; 164 Lemos, Peters, Jansen, Martel, Calhau (bb0780) 2007; 46 Shi, Zhao, Feng, Miao, Dong, Wang, Stalin, Zhang, Tu, Liu, Sun, Wu (bb1240) 2022; 13 Sohrabji, Greene, Miranda, Toran-Allerand (bb1265) 1994; 25 Bahl, Upadhyay, Varma, Singh, Das, Hussain (bb0080) 2023; 12 Kim, Park, Lee, Yang, Park, Kim, Yi, Baek, Sung, Hossen, Lee, Kim, Cho (bb0705) 2015; 2015 Özay, Güzel, Yumrutaş, Pehlivanoğlu, Erdoğdu, Yildirim, Türk, Darcan (bb1025) 2019; 233 Taliyan, Sharma (bb1305) 2012; 26 Lee, Lin, Copland, Dick, Liu (bb0770) 2021; 18 Antal (bb0060) 2010; 17 Beg, Jyoti, Naz, Rahul, Ali, Ali, Reyad, Siddique (bb0095) 2018; 17 Toussaint, Béziau, Charbel, Blanchette, Mayer, Comtois, Ledoux (bb1340) 2017; 31 Copland, Theodoropoulou, Liu, Dick (bb0235) 2018; 59 Triastuti, Park, Choi (bb1345) 2009; 15 Cabrera, Bhaskaran, Xu, Yang, Scott, Mohideen, Ghosh (bb0150) 2016; 57 Zhang, Zhang, Zhang, Lu (bb1530) 2009; 877 Aa, Fei, Qi, Sun, Gu, Di, Aa, Wang, Liu (bb0005) 2020; 41 Chen, Chen (bb0180) 2013; 138 Hussain, Sharma (bb0575) 2022; 72 Alshehri, El-Kott, Eleawa, El-Gerbed, Khalifa, El-Kenawy, Albadrani, Abdel-Daim (bb0050) 2021; 72 Akiyama, Mizokami, Ito, Ikeda (bb0015) 2023; 11 Safarpour, Pirzadeh, Ebrahimpour, Shirafkan, Madani, Hosseini, Moghadamnia, Kazemi (bb1150) 2022; 2022 Kwon, Iba, Kim, Masliah (bb0755) 2020; 17 Chen, Sun, Chen, Xiao, Liu, Chen, Cai, Cai (bb0185) 2010; 81 Pyo, Yun, Yoon, Choi, Lee (bb1085) 2020; 25 Gupta, Hussain, Thapa, Dahiya, Mahapatra, Bhat, Singla, Subramaniyan, Rawat, Jakhmola, S, Dua (bb0475) 2023; 18 Huo, Wang, Zheng, Cong, Xiang, Wang, Sun, Wang, Zhang, Deng, Wu, Ma (bb0560) 2017; 1059 Sharifi-Rad, Fokou, Sharopov, Martorell, Ademiluyi, Rajkovic, Salehi, Martins, Iriti, Sharifi-Rad (bb1225) 2018; 23 Chen, Wang, Sun, Zhang, Ullah, Sun (bb0205) 2021; 128 Hu, Cheng, Heller, Krasnoff, Glahn, Welch (bb0540) 2006; 54 Srivastava (bb1275) 2017; 8 Li, Cheng, Yang, Liu, Zhang, Wang, Du (bb0810) 2019; 1722 Kim, Lee, Kim, Yu, Chung (bb0700) 2010; 32 Fonseca, Gromada, Urano (bb0360) 2011; 22 Memete, Timar, Vuscan, Miere Groza, Venter, Vicas (bb0950) 2022; 11 Huwait, Ayoub, Karim (bb0605) 2022; 23 Cheng, Yang, Yang, Wang, Du (bb0220) 2018; 56 Tasdemir, Banito, Roe, Alonso-Curbelo, Camiolo, Tschaharganeh, Huang, Aksoy, Bolden, Chen, Fennell, Thapar, Chicas, Vakoc, Lowe (bb1325) 2016; 6 Alharbi, Singh, Afzal, Alfawaz Altamimi, Kazmi, Al-Abbasi, Alzarea, Chellappan, Singh, Dua, Gupta (bb0035) 2022; 49 de Zegher, Díaz, Ibáñez (bb0285) 2015; 169 Lytrivi, Castell, Poitout, Cnop (bb0885) 2020; 432 Węsierska, Kloska, Medina, Jakóbkiewicz-Banecka, Gabig-Cimińska, Radzińska, Moskot, Malinowska (bb1410) 2022; 23 Forni, Facchiano, Bartoli, Pieretti, Facchiano, D’Arcangelo, Norelli, Valle, Nisini, Beninati, Tabolacci, Jadeja (bb0370) 2019; 2019 Zhang, Gai, Ma, Tang, Yang, Zu (bb1555) 2023; 102 Zhang, Liu (bb1525) 2011; 670 Huwait, Awaji, Kumosani, Barbour, Abulnaja, Moselhy (bb0600) 2022; 29 Schmitt, Wang, Demaria (bb1185) 2022; 19 Xing, Chen, Zhong (bb1455) 2005; 78 Silva, Rodrigues, Gaspar, Maia, Laires, Rueff (bb1250) 1996; 16 Kampkötter, Gombitang Nkwonkam, Zurawski, Timpel, Chovolou, Wätjen, Kahl (bb0675) 2007; 81 Savarese, Becher, Lund, Seferovic, Rosano, Coats (bb1170) 2023; 118 Bhattacharya, Christensen, Olsen, Christensen, Grevsen, Færgeman, Kristiansen, Young, Oksbjerg (bb0110) 2013; 61 Fang, Gao, Zhu (bb0320) 2008; 82 Nomikos, Nikolaidis, Sousa, Papalois, Rosemann, Knechtle (bb1015) 2018; 9 Farr, Xu, Weivoda, Monroe, Fraser, Onken, Negley, Sfeir, Ogrodnik, Hachfeld, LeBrasseur, Drake, Pignolo, Pirtskhalava, Tchkonia, Oursler, Kirkland, Khosla (bb0335) 2017; 23 Harbo, Delaisse, Kjaersgaard-Andersen, Soerensen, Koelvraa, Bendix (bb0505) 2013; 134 Dai, Shan, Nakamura, Masuko-Hongo, Kato, Nishioka, Yudoh (bb0255) 2006; 54 Pignolo, Suda, McMillan, Shen, Lee, Choi, Wright, Johnson (bb1075) 2008; 7 Chaum, Winborn, Bhattacharya (bb0175) 2015; 26 Leandro, Sykora, Bohr (bb0765) 2015; 776 Zhu, Wen, Zhong, Xiong, Liang, Wang (bb1590) 2018; 15 Yan, He, Xu, Wu, Xiao, Bi, Jia (bb1475) 2019; 33 Hurd, Martorell, Langa (bb0565) 2013; 369 Fielder, von Zglinicki, Jurk (bb0350) 2017; 60 Hussain, Majami, Ali, Gupta, Almalki, Alzarea, Kazmi, Syed, Khalifa, Bin Break, Khan, Altwaijry, Sharma (bb0595) 2023; 251 Yang, Gao, Bajpai, El-Kammar, Simal-Gandara, Cao, Cheng, Wang, Arroo, Zou, Farag, Zhao, Xiao (bb1490) 2023; 63 Jadeja, Powell, Jones, Fuller, Joseph, Thounaojam, Bartoli, Martin (bb0610) 2018; 10 Loeser, Gandhi, Long, Yin, Chubinskaya (bb0860) 2014; 66 Hanaki, Murakami, Akagi, Irie (bb0495) 2016; 24 Rajendran, Ammar, Al-Saeedi, Mohamed, ElNaggar, Al-Ramadan, Bekhet, Soliman (bb1100) 2020; 22 Alam, Khan, Shah, Cauli, Saso (bb0020) 2020; 25 Xiao, Lu, Liu, Luo (bb1435) 2016; 72 Terao, Murota, Kawai (bb1330) 2011; 2 Gupta, Kazmi, Afzal, Rahman, Saleem, Ashraf, Khusroo, Nazeer, Ahmed, Mujeeb, Ahmed, Anwar (bb0470) 2012; 141 Matthews, Gorenne, Scott, Figg, Kirkpatrick, Ritchie, Goddard, Bennett (bb0945) 2006; 99 Loeser (bb0855) 2017; 128 Pathak, Gupta, Gilhotra (bb1060) 2021; 35 Jia, Du, Xu, Dong (bb0645) 2020; 19 Nowak, Matuszewska, Nikodem, Filipiak, Landwójtowicz, Sadanowicz, Jędrzejuk, Rzeszutko, Zduniak, Piasecki, Kowalski, Dziewiszek, Merwid-Ląd, Trocha, Sozański, Kwiatkowska, Bolanowski, Szeląg (bb1020) 2017; 69 Dabeek, Marra (bb0250) 2019; 11 Tang, Li, Chen (bb1315) 2020; 11 Xue, Zender, Miething, Dickins, Hernando, Krizhanovsky, Cordon-Cardo, Lowe (bb1470) 2007; 445 Silva, Rodrigues, Gaspar, Maia, Laires, Rueff (bb1255) 1997; 12 Hertog, Hollman, Katan (bb0520) 1992; 40 Niu, Liao, Zhou, Wang, Wang, Fan (bb1005) 2022; 27 Patel (bb1055) 2021; 21 Chen, Liu, Robinson, Clauson, Blair, Robbins, Niedernhofer, Ouyang (bb0195) 2013; 28 Hein, Rose, van’t Slot, Friedrich, Humpf (bb0510) 2008; 56 Wu, Zhang, Zhang (bb1430) 2017; 14 Chen, Yang, Liu, Guan, Feng, Dong, Chu, Liu, Tian, Ci, Li, Wei, Deng, Deng, Chi, Sun (bb0190) 2012; 14 MacGregor, Jurd (bb0900) 1978; 54 Zhang, Gaiteri, Bodea, Wang, McElwee, Podtelezhnikov, Zhang, Xie, Tran, Dobrin, Fluder, Clurman, Melquist, Narayanan, Suver, Shah, Mahajan, Gillis, Mysore, MacDonald, Lamb, Bennett, Molony, Stone, Gudnason, Myers, Schadt, Neumann, Zhu, Emilsson (bb1535) 2013; 153 Alharbi, Afzal, Almalki, Kazmi, Javed Shaikh, Thangavelu, Gulati, Singh, Jha, Gupta, Chellappan, Oliver, Dua, Gupta (bb0030) 2022; 354 Potschka, Brodie (bb1080) 2012; 108 Parfitt (bb1045) 1984; 36 Saeed, Qiu, Li, Flyvbjerg, Abdallah, Kassem (bb1145) 2015; 16 Zhang, Raghavan, Satin (bb1540) 2020; 161 Labib, Hummel, Richling, Humpf, Schreier (bb0760) 2006; 50 Kong, Luo, Li, Zhou, He (bb0720) 2013; 12 Anderson, Lagnado, Maggiorani, Walaszczyk, Dookun, Chapman, Birch, Salmonowicz, Ogrodnik, Jurk, Proctor, Correia-Melo, Victorelli, Fielder, Berlinguer-Palmini, Owens, Greaves, Kolsky, Parini, Douin-Echinard, LeBrasseur, Arthur, Tual-Chalot, Schafer, Roos, Miller, Robertson, Mann, Adams, Tchkonia, Kirkland, Mialet-Perez, Richardson, Passos (bb0055) 2019; 38 Mira, Fernandez, Santos, Rocha, Florêncio, Jennings (bb0970) 200 Kim (10.1016/j.exger.2024.112389_bb0700) 2010; 32 Jeon (10.1016/j.exger.2024.112389_bb0625) 2017; 23 Hussain (10.1016/j.exger.2024.112389_bb0580) 2023; 249 Kowalczyk (10.1016/j.exger.2024.112389_bb0730) 2021; 22 Alevriadou (10.1016/j.exger.2024.112389_bb0025) 2021; 320 Li (10.1016/j.exger.2024.112389_bb0815) 2020; 72 Pan (10.1016/j.exger.2024.112389_bb1035) 2020; 74 Liu (10.1016/j.exger.2024.112389_bb0850) 2019; 21 Zhang (10.1016/j.exger.2024.112389_bb1535) 2013; 153 Alshehri (10.1016/j.exger.2024.112389_bb0050) 2021; 72 Roy (10.1016/j.exger.2024.112389_bb1140) 2016; 531 Kishore (10.1016/j.exger.2024.112389_bb0710) 2018; 26 Vezzani (10.1016/j.exger.2024.112389_bb1365) 2011; 7 Jeppesen (10.1016/j.exger.2024.112389_bb0635) 2011; 94 Tang (10.1016/j.exger.2024.112389_bb1315) 2020; 11 Khan (10.1016/j.exger.2024.112389_bb0685) 2019; 55 Lemos (10.1016/j.exger.2024.112389_bb0780) 2007; 46 Hurd (10.1016/j.exger.2024.112389_bb0565) 2013; 369 Montero (10.1016/j.exger.2024.112389_bb0980) 2004; 384 Xu (10.1016/j.exger.2024.112389_bb1460) 2017; 50 Fontana (10.1016/j.exger.2024.112389_bb0365) 2018; 176 de la Garza (10.1016/j.exger.2024.112389_bb0275) 2019; 11 Matsumoto (10.1016/j.exger.2024.112389_bb0940) 2015; 20 Huang (10.1016/j.exger.2024.112389_bb0550) 2020; 34 Huang (10.1016/j.exger.2024.112389_bb0555) 2021 Pignolo (10.1016/j.exger.2024.112389_bb1075) 2008; 7 DuPont (10.1016/j.exger.2024.112389_bb0305) 2004; 58 Lee (10.1016/j.exger.2024.112389_bb0770) 2021; 18 Tuñón (10.1016/j.exger.2024.112389_bb1355) 2009; 10 Aunan (10.1016/j.exger.2024.112389_bb0065) 2017; 8 Chen (10.1016/j.exger.2024.112389_bb0185) 2010; 81 Almatroudi (10.1016/j.exger.2024.112389_bb0040) 2023; 24 Li (10.1016/j.exger.2024.112389_bb0785) 2011; 34 Bahl (10.1016/j.exger.2024.112389_bb0075) 2023; 13 González-Trujano (10.1016/j.exger.2024.112389_bb0450) 2017; 92 Stilling (10.1016/j.exger.2024.112389_bb1280) 2014; 8 Sujarwo (10.1016/j.exger.2024.112389_bb1290) 2016; 189 Mahomoodally (10.1016/j.exger.2024.112389_bb0910) 2022; 13 Hua (10.1016/j.exger.2024.112389_bb0545) 2022; 46 Xie (10.1016/j.exger.2024.112389_bb1450) 2021; 12 Yan (10.1016/j.exger.2024.112389_bb1480) 2021; 10 Niering (10.1016/j.exger.2024.112389_bb1000) 2005; 209 Wang (10.1016/j.exger.2024.112389_bb1385) 2012; 111 Bermont (10.1016/j.exger.2024.112389_bb0105) 2020; 12 Sohrabji (10.1016/j.exger.2024.112389_bb1265) 1994; 25 Zhang (10.1016/j.exger.2024.112389_bb1555) 2023; 102 Blanco-Salas (10.1016/j.exger.2024.112389_bb0120) 2019; 8 Kubina (10.1016/j.exger.2024.112389_bb0740) 2023; 12 Li (10.1016/j.exger.2024.112389_bb0810) 2019; 1722 MacGregor (10.1016/j.exger.2024.112389_bb0900) 1978; 54 Sengupta (10.1016/j.exger.2024.112389_bb1200) 2022; 214 Wang (10.1016/j.exger.2024.112389_bb1395) 2021; 21 Walle (10.1016/j.exger.2024.112389_bb1380) 2004; 36 Antal (10.1016/j.exger.2024.112389_bb0060) 2010; 17 Roth (10.1016/j.exger.2024.112389_bb1135) 1999; 57 Anderson (10.1016/j.exger.2024.112389_bb0055) 2019; 38 Gupta (10.1016/j.exger.2024.112389_bb0470) 2012; 141 Janić (10.1016/j.exger.2024.112389_bb0615) 2019; 20 Suchal (10.1016/j.exger.2024.112389_bb1285) 2017; 18 Abdullah (10.1016/j.exger.2024.112389_bb0010) 2018; 8 Hussain (10.1016/j.exger.2024.112389_bb0585) 2023; 249 Schneider (10.1016/j.exger.2024.112389_bb1190) 2000; 173 Kong (10.1016/j.exger.2024.112389_bb0720) 2013; 12 Copland (10.1016/j.exger.2024.112389_bb0235) 2018; 59 Xue (10.1016/j.exger.2024.112389_bb1470) 2007; 445 Jia (10.1016/j.exger.2024.112389_bb0640) 2019; 1865 Kroon (10.1016/j.exger.2024.112389_bb0735) 2004; 80 Liu (10.1016/j.exger.2024.112389_bb0845) 2013; 112 Kumar (10.1016/j.exger.2024.112389_bb0750) 2023; 19 Xu (10.1016/j.exger.2024.112389_bb1465) 2023; 14 Kaneko (10.1016/j.exger.2024.112389_bb0680) 2017; 5 Tang (10.1016/j.exger.2024.112389_bb1320) 2022; 2022 Farlow (10.1016/j.exger.2024.112389_bb0325) 2008; 25 Yu (10.1016/j.exger.2024.112389_bb1510) 2022; 366 Rajendran (10.1016/j.exger.2024.112389_bb1095) 2014; 86 Chen (10.1016/j.exger.2024.112389_bb0180) 2013; 138 Lotito (10.1016/j.exger.2024.112389_bb0880) 2006; 281 Chen (10.1016/j.exger.2024.112389_bb0210) 2022; 118 Liu (10.1016/j.exger.2024.112389_bb0840) 2009; 32 Rim (10.1016/j.exger.2024.112389_bb1125) 2020; 21 Wu (10.1016/j.exger.2024.112389_bb1430) 2017; 14 Hussain (10.1016/j.exger.2024.112389_bb0595) 2023; 251 Wall (10.1016/j.exger.2024.112389_bb1375) 2013; 2013 Yan (10.1016/j.exger.2024.112389_bb1475) 2019; 33 Shahnawaz (10.1016/j.exger.2024.112389_bb1215) 2020; 578 Gupta (10.1016/j.exger.2024.112389_bb0475) 2023; 18 Xiao (10.1016/j.exger.2024.112389_bb1440) 2021; 6 Niu (10.1016/j.exger.2024.112389_bb1005) 2022; 27 Li (10.1016/j.exger.2024.112389_bb0825) 2022; 101 Hussain (10.1016/j.exger.2024.112389_bb0590) 2023; 37 Saeed (10.1016/j.exger.2024.112389_bb1145) 2015; 16 Kampkötter (10.1016/j.exger.2024.112389_bb0675) 2007; 81 Palmer (10.1016/j.exger.2024.112389_bb1030) 2019; 62 Huo (10.1016/j.exger.2024.112389_bb0560) 2017; 1059 Howden (10.1016/j.exger.2024.112389_bb0535) 2013; 2013 Bonetti (10.1016/j.exger.2024.112389_bb0135) 2007; 58 Grootaert (10.1016/j.exger.2024.112389_bb0455) 2021; 128 Halbwirth (10.1016/j.exger.2024.112389_bb0485) 2010; 11 Loeser (10.1016/j.exger.2024.112389_bb0855) 2017; 128 Węsierska (10.1016/j.exger.2024.112389_bb1410) 2022; 23 Barve (10.1016/j.exger.2024.112389_bb0090) 2009; 30 Madhu (10.1016/j.exger.2024.112389_bb0905) 2017; 11 Silva (10.1016/j.exger.2024.112389_bb1255) 1997; 12 Scheibye-Knudsen (10.1016/j.exger.2024.112389_bb1175) 2016; 63 Huwait (10.1016/j.exger.2024.112389_bb0600) 2022; 29 Farr (10.1016/j.exger.2024.112389_bb0335) 2017; 23 Choi (10.1016/j.exger.2024.112389_bb0230) 2013; 84 Francis (10.1016/j.exger.2024.112389_bb0380) 1989; 10 Ren (10.1016/j.exger.2024.112389_bb1110) 2016; 6 Beg (10.1016/j.exger.2024.112389_bb0095) 2018; 17 Toussaint (10.1016/j.exger.2024.112389_bb1340) 2017; 31 Feng (10.1016/j.exger.2024.112389_bb0340) 2017; 83 Nowak (10.1016/j.exger.2024.112389_bb1020) 2017; 69 Han (10.1016/j.exger.2024.112389_bb0490) 2019; 15 Taliyan (10.1016/j.exger.2024.112389_bb1305) 2012; 26 Mira (10.1016/j.exger.2024.112389_bb0970) 2002; 36 Santos (10.1016/j.exger.2024.112389_bb1165) 2017 Bokkenheuser (10.1016/j.exger.2024.112389_bb0130) 1987; 248 Zarei (10.1016/j.exger.2024.112389_bb1515) 2019; 129 Zhu (10.1016/j.exger.2024.112389_bb1590) 2018; 15 Wiciński (10.1016/j.exger.2024.112389_bb1415) 2023; 15 Zeng (10.1016/j.exger.2024.112389_bb1520) 2021; 47 Zhong (10.1016/j.exger.2024.112389_bb1585) 2022; 8 Savarese (10.1016/j.exger.2024.112389_bb1170) 2023; 118 Alharbi (10.1016/j.exger.2024.112389_bb0035) 2022; 49 Singh (10.1016/j.exger.2024.112389_bb1260) 2023; 19 Boyang (10.1016/j.exger.2024.112389_bb0140) 2022; 101 Chen (10.1016/j.exger.2024.112389_bb0215) 2023; 12 Martin (10.1016/j.exger.2024.112389_bb0930) 2004 Alharbi (10.1016/j.exger.2024.112389_bb0030) 2022; 354 Salehi (10.1016/j.exger.2024.112389_bb1160) 2018; 8 Huwait (10.1016/j.exger.2024.112389_bb0605) 2022; 23 Georgiadou (10.1016/j.exger.2024.112389_bb0430) 2020; 91 Noguchi (10.1016/j.exger.2024.112389_bb1010) 2023; 39 Sene (10.1016/j.exger.2024.112389_bb1195) 2013; 17 Parfitt (10.1016/j.exger.2024.112389_bb1045) 1984; 36 Jayaprakashkamath (10.1016/j.exger.2024.112389_bb0620) 2023; 19 Schiro (10.1016/j.exger.2024.112389_bb1180) 2014; 234 Biundo (10.1016/j.exger.2024.112389_bb0115) 2017; 7 Takahashi (10.1016/j.exger.2024.112389_bb1295) 2014; 9 Crespy (10.1016/j.exger.2024.112389_bb0245) 2003; 284 Fonseca (10.1016/j.exger.2024.112389_bb0360) 2011; 22 Vijayaprakash (10.1016/j.exger.2024.112389_bb1370) 2013; 3 Matthews (10.1016/j.exger.2024.112389_bb0945) 2006; 99 Fürer (10.1016/j.exger.2024.112389_bb0385) 2013; 79 Wang (10.1016/j.exger.2024.112389_bb1390) 2003; 28 Manivannan (10.1016/j.exger.2024.112389_bb0920) 2015; 56 Bhattacharya (10.1016/j.exger.2024.112389_bb0110) 2013; 61 Du (10.1016/j.exger.2024.112389_bb0295) 2018; 2018 Kouhestani (10.1016/j.exger.2024.112389_bb0725) 2018; 13 Sharma (10.1016/j.exger.2024.112389_bb1230) 2020; 76 Dwivedy (10.1016/j.exger.2024.112389_bb0310) 2017; 106 Milošević (10.1016/j.exger.2024.112389_bb0965) 2021; 8 Zhao (10.1016/j.exger.2024.112389_bb1570) 2020; 716 Bahl (10.1016/j.exger.2024.112389_bb0080) 2023; 12 Reuter (10.1016/j.exger.2024.112389_bb1120) 2010; 49 Husnunnisa (10.1016/j.exger.2024.112389_bb0570) 2022; 69 Li (10.1016/j.exger.2024.112389_bb0805) 2019; 20 García-Mediavilla (10.1016/j.exger.2024.112389_bb0415) 2007; 557 Knopman (10.1016/j.exger.2024.112389_bb0715) 2021; 7 Murillo-Rodríguez (10.1016/j.exger.2024.112389_bb0985) 2020; 18 Forni (10.1016/j.exger.2024.112389_bb0370) 2019; 2019 Deng (10.1016/j.exger.2024.112389_bb0290) 2022; 9 Al-Numair (10.1016/j.exger.2024.112389_bb0045) 2015; 20 Pietta (10.1016/j.exger.2024.112389_bb1070) 2000; 63 Loeser (10.1016/j.exger.2024.112389_bb0860) 2014; 66 Özay (10.1016/j.exger.2024.112389_bb1025) 2019; 233 Jung (10.1016/j.exger.2024.112389_bb0660) 2022; 23 Ma (10.1016/j.exger.2024.112389_bb0895) 2015; 22 Kim (10.1016/j.exger.2024.112389_bb0705) 2015; 2015 Park (10.1016/j.exger.2024.112389_bb1050) 2011; 164 Trovato Salinaro (10.1016/j.exger.2024.112389_bb1350) 2018; 15 Ferreira (10.1016/j.exger.2024.112389_bb0345) 2018; 103 Jadeja (10.1016/j.exger.2024.112389_bb0610) 2018; 10 Zhao (10.1016/j.exger.2024.112389_bb1560) 2011; 121 Jia (10.1016/j.exger.2024.112389_bb0645) 2020; 19 Garg (10.1016/j.exger.2024.112389_bb0420) 2018 Manach (10.1016/j.exger.2024.112389_bb0915) 1997; 409 Hanaki (10.1016/j.exger.2024.112389_bb0495) 2016; 24 Martini (10.1016/j.exger.2024.112389_bb0935) 2021; 22 Khandelwal (10.1016/j.exger.2024.112389_bb0690) 2023; 12 Sengupta (10.1016/j.exger.2024.112389_bb1205) 2022; 22 Jiapaer (10.1016/j.exger.2024.112389_bb0650) 2022; 21 Schmitt (10.1016/j.exger.2024.112389_bb1185) 2022; 19 Sharoar (10.1016/j.exger.2024.112389_bb1235) 2012; 19 Takanashi (10.1016/j.exger.2024.112389_bb1300) 1983; 5 López-Otín (10.1016/j.exger.2024.112389_bb0875) 2013; 153 Cheng (10.1016/j.exger.2024.112389_bb0220) 2018; 56 Barbour (10.1016/j.exger.2024.112389_bb0085) 2017; 66 Zheng (10.1016/j.exger.2024.112389_bb1575) 2022; 2022 Panahi (10.1016/j.exger.2024.112389_bb1040) 2016; 15 Akiyama ( |
| References_xml | – volume: 94 start-page: 166 year: 2011 end-page: 200 ident: bb0635 article-title: DNA repair deficiency in neurodegeneration publication-title: Prog. Neurobiol. – volume: 8 year: 2019 ident: bb0120 article-title: Bioactive phytochemicals from Mercurialis spp. used in traditional spanish medicine publication-title: Plants (Basel, Switzerland) – volume: 15 year: 2023 ident: bb0225 article-title: Immunomodulation in age-related disorders and nanotechnology interventions publication-title: Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. – volume: 14 start-page: 218 year: 1993 end-page: 221 ident: bb0890 article-title: Second peak of plasma diazepam concentration and enterogastric circulation publication-title: Zhongguo Yao Li Xue Bao = Acta Pharmacol. Sin. – volume: 21 start-page: 104 year: 2021 end-page: 114 ident: bb1055 article-title: Pharmacological activities and therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: a review of medicinal importance and health benefits publication-title: Cardiovasc. Hematol. Disord. Drug Targets – volume: 72 year: 2021 ident: bb0050 article-title: Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1. Journal of physiology and pharmacology : an official journal of the Polish Physiological publication-title: Society – volume: 128 start-page: 474 year: 2021 end-page: 491 ident: bb0455 article-title: SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis publication-title: Circ. Res. – volume: 22 start-page: 266 year: 2011 end-page: 274 ident: bb0360 article-title: Endoplasmic reticulum stress and pancreatic β-cell death publication-title: Trends Endocrinol. Metab. – volume: 369 start-page: 489 year: 2013 end-page: 490 ident: bb0565 article-title: Monetary costs of dementia in the United States publication-title: N. Engl. J. Med. – volume: 13 year: 2022 ident: bb0910 article-title: Plants’ bioactive secondary metabolites in the management of sepsis: recent findings on their mechanism of action publication-title: Front. Pharmacol. – volume: 177 start-page: 91 year: 2002 end-page: 104 ident: bb0390 article-title: Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics publication-title: Toxicology – volume: 5 start-page: 55 year: 1983 end-page: 60 ident: bb1300 article-title: Carcinogenicity test of quercetin and kaempferol in rats by oral administration publication-title: J. Food Saf. – volume: 16 start-page: 144 year: 2010 end-page: 153 ident: bb0865 article-title: A new view of carcinogenesis and an alternative approach to cancer therapy publication-title: Molecular Medicine (Cambridge, Mass). – volume: 54 start-page: 1492 year: 1989 end-page: 1495 ident: bb0355 article-title: Mutagenic flavonol aglycones in infusions and in fresh and pickled vegetables publication-title: J. Food Sci. – volume: 14 start-page: 209 year: 2012 end-page: 216 ident: bb0190 article-title: Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice publication-title: Int. Immunopharmacol. – volume: 366 year: 2022 ident: bb1510 article-title: Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity publication-title: Chem. Biol. Interact. – volume: 24 year: 2023 ident: bb0040 article-title: Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways publication-title: Int. J. Mol. Sci. – volume: 56 start-page: 29 year: 2018 end-page: 35 ident: bb0220 article-title: Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway publication-title: Int. Immunopharmacol. – volume: 222 start-page: 393 year: 1989 end-page: 401 ident: bb0375 article-title: Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids publication-title: Mutat. Res. – volume: 50 year: 2017 ident: bb1460 article-title: Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment publication-title: Brazilian Journal of Medical and Biological Research = Revista brasileira de pesquisas medicas e biologicas. – volume: 20 year: 2019 ident: bb0615 article-title: Expression of longevity genes induced by a low-dose fluvastatin and valsartan combination with the potential to prevent/treat “aging-related disorders” publication-title: Int. J. Mol. Sci. – volume: 63 start-page: 2773 year: 2023 end-page: 2789 ident: bb1490 article-title: Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives publication-title: Crit. Rev. Food Sci. Nutr. – volume: 36 start-page: 1199 year: 2002 end-page: 1208 ident: bb0970 article-title: Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity publication-title: Free Radic. Res. – volume: 91 year: 2020 ident: bb0430 article-title: Control by Ca(2+) of mitochondrial structure and function in pancreatic β-cells publication-title: Cell Calcium – volume: 80 start-page: 15 year: 2004 end-page: 21 ident: bb0735 article-title: How should we assess the effects of exposure to dietary polyphenols in vitro? publication-title: Am. J. Clin. Nutr. – volume: 9 year: 2020 ident: bb0525 article-title: Pharmacological targets of kaempferol within inflammatory pathways-a hint towards the central role of tryptophan metabolism publication-title: Antioxidants (Basel, Switzerland) – volume: 15 start-page: 3425 year: 2021 end-page: 3441 ident: bb1550 article-title: Network pharmacology and experimental evidence: PI3K/AKT signaling pathway is involved in the antidepressive roles of Chaihu Shugan San publication-title: Drug Des. Devel. Ther. – volume: 41 start-page: 73 year: 2020 end-page: 81 ident: bb0005 article-title: Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol publication-title: Acta Pharmacol. Sin. – volume: 6 year: 2016 ident: bb1110 article-title: Neuroprotective effects of a standardized flavonoid extract of safflower against neurotoxin-induced cellular and animal models of Parkinson’s disease publication-title: Sci. Rep. – volume: 20 start-page: 198 year: 2015 end-page: 209 ident: bb0045 article-title: Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats publication-title: Redox Report: Communications in Free Radical Research. – volume: 40 start-page: 2379 year: 1992 end-page: 2383 ident: bb0520 article-title: Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands publication-title: J. Agric. Food Chem. – volume: 22 start-page: 1159 year: 2015 end-page: 1162 ident: bb0895 article-title: Kaempferitrin prevents bone lost in ovariectomized rats publication-title: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. – volume: 112 start-page: e99 year: 2013 end-page: 109 ident: bb0845 article-title: Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells publication-title: Circ. Res. – volume: 1865 start-page: 1802 year: 2019 end-page: 1809 ident: bb0640 article-title: Endothelial cell senescence in aging-related vascular dysfunction publication-title: Biochim. Biophys. Acta Mol. basis Dis. – volume: 104 start-page: 193 year: 1996 end-page: 196 ident: bb1155 article-title: Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei publication-title: Cancer Lett. – volume: 82 start-page: 615 year: 2008 end-page: 622 ident: bb0320 article-title: Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity publication-title: Life Sci. – volume: 12 year: 2023 ident: bb0080 article-title: Chronic calcific pancreatitis presented with secondary diabetes and diabetic ketoacidosis: a case report publication-title: Clin. Diabetol. – volume: 22 year: 2021 ident: bb0935 article-title: Selective cardiomyocyte oxidative stress leads to bystander senescence of cardiac stromal cells publication-title: Int. J. Mol. Sci. – volume: 11 start-page: 224 year: 2009 ident: bb0435 article-title: Cartilage homeostasis in health and rheumatic diseases publication-title: Arthritis Res. Ther. – volume: 50 start-page: 78 year: 2006 end-page: 86 ident: bb0760 article-title: Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds publication-title: Mol. Nutr. Food Res. – volume: 2022 year: 2022 ident: bb1090 article-title: Orientin prolongs the longevity of Caenorhabditis elegans and postpones the development of neurodegenerative diseases via nutrition sensing and cellular protective pathways publication-title: Oxidative Med. Cell. Longev. – volume: 2 start-page: 11 year: 2011 end-page: 17 ident: bb1330 article-title: Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo publication-title: Food Funct. – volume: 1059 start-page: 14 year: 2017 end-page: 20 ident: bb0560 article-title: Comparative pharmacokinetic study of baicalin and its metabolites after oral administration of baicalin and Chaiqin Qingning capsule in normal and febrile rats publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – volume: 134 start-page: 367 year: 2013 end-page: 372 ident: bb0505 article-title: The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis publication-title: Mech. Ageing Dev. – volume: 8 year: 2017 ident: bb1275 article-title: The mitochondrial basis of aging and age-related disorders publication-title: Genes – volume: 11 start-page: 1177 year: 2019 end-page: 1188 ident: bb0995 article-title: Nutraceutical effects of Emblicaofficinalis in age-related macular degeneration publication-title: Aging – volume: 21 year: 2022 ident: bb0650 article-title: Regulation and roles of RNA modifications in aging-related diseases publication-title: Aging Cell – volume: 24 start-page: 304 year: 2016 end-page: 313 ident: bb0495 article-title: Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids publication-title: Bioorg. Med. Chem. – volume: 15 start-page: 8 year: 2018 ident: bb1350 article-title: Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms publication-title: Immun. Ageing – volume: 9 start-page: 62 year: 2022 end-page: 79 ident: bb0290 article-title: Age-related macular degeneration: epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy publication-title: Genes & Diseases. – volume: 14 start-page: 56 year: 2023 end-page: 73 ident: bb1465 article-title: Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging publication-title: Food Funct. – volume: 12 year: 2023 ident: bb0215 article-title: A critical review of kaempferol in intestinal health and diseases publication-title: Antioxidants (Basel, Switzerland) – volume: 557 start-page: 221 year: 2007 end-page: 229 ident: bb0415 article-title: The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang liver cells publication-title: Eur. J. Pharmacol. – volume: 25 year: 2021 ident: bb1210 article-title: P53 regulation of osteoblast differentiation is mediated through specific microRNAs publication-title: Biochemistry and Biophysics Reports. – volume: 35 start-page: 25 year: 2021 end-page: 33 ident: bb1060 article-title: The role of diazepam in epigenetics: from the molecular level to clinical implications publication-title: Adv. Mind Body Med. – volume: 34 start-page: 1291 year: 2011 end-page: 1296 ident: bb0785 article-title: Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson’s disease publication-title: Biol. Pharm. Bull. – volume: 13 year: 2022 ident: bb1240 article-title: Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: network pharmacology and experimental validation publication-title: Front. Pharmacol. – volume: 49 start-page: 3106 year: 2001 end-page: 3112 ident: bb0960 article-title: Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants publication-title: J. Agric. Food Chem. – volume: 5 start-page: 371 year: 2021 ident: bb0240 article-title: Exercise-associated pathways as novel neuroprotectants against CNS aging and Alzheimer’s disease publication-title: Innov. Aging – volume: 23 year: 2022 ident: bb1065 article-title: Kaempferol: antimicrobial properties, sources, clinical, and traditional applications publication-title: Int. J. Mol. Sci. – volume: 118 start-page: 1173 year: 2022 end-page: 1187 ident: bb0210 article-title: Senescence mechanisms and targets in the heart publication-title: Cardiovasc. Res. – volume: 10 start-page: 2464 year: 2020 ident: bb1545 article-title: Dysregulated metabolic pathways in age-related macular degeneration publication-title: Sci. Rep. – volume: 12 year: 2023 ident: bb0740 article-title: Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells publication-title: Cells – volume: 21 start-page: 396 year: 2021 ident: bb1395 article-title: Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling publication-title: BMC Cancer – volume: 59 start-page: amd83 year: 2018 end-page: amd92 ident: bb0235 article-title: A perspective of AMD through the eyes of immunology publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 111 start-page: 245 year: 2012 end-page: 259 ident: bb1385 article-title: Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence publication-title: Circ. Res. – volume: 54 start-page: 9254 year: 2006 end-page: 9261 ident: bb0540 article-title: Kaempferol in red and pinto bean seed (Phaseolus vulgaris L.) coats inhibits iron bioavailability using an in vitro digestion/human Caco-2 cell model publication-title: J. Agric. Food Chem. – volume: 12 year: 2023 ident: bb0690 article-title: The intersection of obesity and skeletal health: insights from post-COVID-19 Indian population publication-title: Clinical Diabetology. – volume: 101 year: 2022 ident: bb0825 article-title: Potential active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking publication-title: Medicine – volume: 16 start-page: 229 year: 1996 end-page: 241 ident: bb1250 article-title: Mutagenicity of kaempferol in V79 cells: the role of cytochromes P450 publication-title: Teratog. Carcinog. Mutagen. – volume: 84 start-page: 545 year: 2013 end-page: 555 ident: bb0230 article-title: Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction publication-title: J. Periodontol. – volume: 18 start-page: 32 year: 2021 ident: bb0770 article-title: Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration publication-title: J. Neuroinflammation – volume: 103 start-page: 249 year: 2010 end-page: 255 ident: bb0160 article-title: The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake publication-title: Br. J. Nutr. – volume: 27 year: 2022 ident: bb1005 article-title: Flavonoids from publication-title: Molecules (Basel, Switzerland) – volume: 20 start-page: 728 year: 2019 end-page: 734 ident: bb0805 article-title: Synergistic effect of kaempferol and 5-fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway publication-title: Mol. Med. Rep. – volume: 3 year: 2018 ident: bb0835 article-title: Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration publication-title: JCI Insight – volume: 13 start-page: 1827 year: 2018 end-page: 1832 ident: bb0725 article-title: Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia publication-title: Neural Regen. Res. – volume: 19 start-page: 651 year: 2020 end-page: 659 ident: bb0645 article-title: Comparative pharmacokinetic study of five flavonoids in normal rats and rats with gastric ulcer following oral administration of Mongolian medicine, Shudage-4 by UPLC–ESI–MS/MS publication-title: Trop. J. Pharm. Res. – volume: 251 year: 2023 ident: bb0595 article-title: The complex role of MEG3: an emerging long non-coding RNA in breast cancer publication-title: Pathol. Res. Pract. – volume: 35 start-page: 2645 year: 2015 end-page: 2650 ident: bb0665 article-title: Kaempferol is an anti-inflammatory compound with activity towards NF-κB pathway proteins publication-title: Anticancer Res. – volume: 578 start-page: 273 year: 2020 end-page: 277 ident: bb1215 article-title: Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy publication-title: Nature – volume: 23 year: 2018 ident: bb1225 article-title: Antiulcer agents: from plant extracts to phytochemicals in healing promotion publication-title: Molecules (Basel, Switzerland) – volume: 22 year: 2021 ident: bb0730 article-title: Mitochondrial oxidative stress-a causative factor and therapeutic target in many diseases publication-title: Int. J. Mol. Sci. – volume: 76 year: 2020 ident: bb1230 article-title: Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: an in vitro and in vivo study in diabetic nephropathy mice model publication-title: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. – volume: 409 start-page: 12 year: 1997 end-page: 16 ident: bb0915 article-title: Bioavailability of rutin and quercetin in rats publication-title: FEBS Lett. – volume: 16 start-page: 733 year: 2015 end-page: 745 ident: bb1145 article-title: Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway publication-title: Biogerontology – volume: 36 start-page: 829 year: 2004 end-page: 837 ident: bb1380 article-title: Absorption and metabolism of flavonoids publication-title: Free Radic. Biol. Med. – volume: 6 start-page: 612 year: 2016 end-page: 629 ident: bb1325 article-title: BRD4 connects enhancer remodeling to senescence immune surveillance publication-title: Cancer Discov. – volume: 26 start-page: 1823 year: 2012 end-page: 1829 ident: bb1305 article-title: Protective effect and potential mechanism of Ginkgo biloba extract EGb 761 on STZ-induced neuropathic pain in rats publication-title: Phytotherapy Research: PTR. – volume: 65 start-page: 615 year: 2022 end-page: 636 ident: bb0410 article-title: Pathophysiology of age-related macular degeneration: implications for treatment publication-title: Ophthalmic Res. – volume: 11 start-page: 280 year: 2020 ident: bb1315 article-title: Cardiomyocyte senescence and cellular communications within myocardial microenvironments publication-title: Front. Endocrinol. – volume: 17 start-page: 1156 year: 2014 end-page: 1163 ident: bb0270 article-title: Alzheimer’s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci publication-title: Nat. Neurosci. – year: 2021 ident: bb0555 article-title: Traditional Chinese Medicine Drynariae Rhizoma and Cuscuta Chinensis Suppress Osteoarthritis by Quercetin-AKT1 and Luteolin-IL6/VEGFA Direct Binding – volume: 19 start-page: 619 year: 2022 end-page: 636 ident: bb1185 article-title: Senescence and cancer - role and therapeutic opportunities publication-title: Nat. Rev. Clin. Oncol. – volume: 66 start-page: 246 year: 2017 end-page: 253 ident: bb0085 article-title: Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2013-2015 publication-title: MMWR Morb. Mortal Wkly. Rep. – volume: 58 start-page: 14 year: 2014 end-page: 18 ident: bb0425 article-title: What is an anti-aging treatment? publication-title: Exp. Gerontol. – volume: 11 start-page: 433 year: 1976 end-page: 448 ident: bb0515 article-title: Flavonols and flavones in food plants: a review publication-title: Int. J. Food Sci. Technol. – volume: 716 year: 2020 ident: bb1570 article-title: Kaempferol protects retinal ganglion ceils from high-glucose-induced injury by regulating vasohibin-1 publication-title: Neurosci. Lett. – volume: 103 start-page: 110 year: 2018 end-page: 120 ident: bb0345 article-title: Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: an in vitro evaluation with focus on antiepileptic drugs publication-title: Food Research International (Ottawa, Ont). – volume: 30 start-page: 356 year: 2009 end-page: 365 ident: bb0090 article-title: Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats publication-title: Biopharm. Drug Dispos. – volume: 128 start-page: 1229 year: 2018 end-page: 1237 ident: bb0630 article-title: Senescent cells and osteoarthritis: a painful connection publication-title: J. Clin. Invest. – volume: 5 start-page: 1395 year: 2014 end-page: 1402 ident: bb1485 article-title: Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells publication-title: Food Funct. – volume: 10 start-page: 1306 year: 2018 end-page: 1323 ident: bb0610 article-title: Loss of NAMPT in aging retinal pigment epithelium reduces NAD(+) availability and promotes cellular senescence publication-title: Aging – volume: 18 start-page: 283 year: 2014 end-page: 292 ident: bb1565 article-title: Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling publication-title: J. Cell. Mol. Med. – volume: 26 start-page: 210 year: 2015 end-page: 221 ident: bb0175 article-title: Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium publication-title: Mammalian Genome: Official Journal of the International Mammalian Genome Society. – volume: 531 start-page: 508 year: 2016 end-page: 512 ident: bb1140 article-title: Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease publication-title: Nature – volume: 10 start-page: 7706 year: 2021 end-page: 7720 ident: bb1480 article-title: Molecular mechanism of Wutou Decoction in the treatment of osteoarthritis: a bioinformatics and molecular docking study publication-title: Annals of Palliative Medicine. – volume: 354 year: 2022 ident: bb0030 article-title: Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases publication-title: Chem. Biol. Interact. – volume: 138 start-page: 2099 year: 2013 end-page: 2107 ident: bb0180 article-title: A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention publication-title: Food Chem. – volume: 101 year: 2022 ident: bb0140 article-title: Mechanism of Epimedium intervention in heart failure based on network pharmacology and molecular docking technology publication-title: Medicine – volume: 877 start-page: 3595 year: 2009 end-page: 3600 ident: bb1530 article-title: Sensitive determination of kaempferol in rat plasma by high-performance liquid chromatography with chemiluminescence detection and application to a pharmacokinetic study publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – volume: 12 start-page: 115 year: 2013 ident: bb0720 article-title: The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits publication-title: Lipids Health Dis. – volume: 81 start-page: 1045 year: 2010 end-page: 1052 ident: bb0185 article-title: Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats publication-title: Fitoterapia – volume: 7 start-page: 33 year: 2021 ident: bb0715 article-title: Alzheimer disease publication-title: Nat. Rev. Dis. Primers – volume: 32 start-page: 489 year: 2009 end-page: 492 ident: bb0840 article-title: Synergistic effect of kaempferol glycosides purified from Laurus nobilis and fluoroquinolones on methicillin-resistant Staphylococcus aureus publication-title: Biol. Pharm. Bull. – volume: 23 start-page: 3925 year: 2017 end-page: 3931 ident: bb1595 article-title: Kaempferol alleviates the interleukin-1β-induced inflammation in rat osteoarthritis chondrocytes via suppression of NF-κB publication-title: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. – volume: 60 start-page: 83 year: 2018 end-page: 94 ident: bb0200 article-title: Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress publication-title: Endocrine – volume: 8 year: 2013 ident: bb1505 article-title: Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke publication-title: PLoS One – volume: 14 start-page: R12 year: 2012 ident: bb0500 article-title: The distribution pattern of critically short telomeres in human osteoarthritic knees publication-title: Arthritis Res. Ther. – volume: 18 start-page: 97 year: 2020 end-page: 108 ident: bb0985 article-title: The endocannabinoid system may modulate sleep disorders in aging publication-title: Curr. Neuropharmacol. – volume: 153 start-page: 707 year: 2013 end-page: 720 ident: bb1535 article-title: Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease publication-title: Cell – start-page: S96 year: 2004 end-page: S103 ident: bb0930 article-title: Chondrocyte senescence, joint loading and osteoarthritis publication-title: Clin. Orthop. Relat. Res. – volume: 11 year: 2019 ident: bb0250 article-title: Dietary quercetin and kaempferol: bioavailability and potential cardiovascular-related bioactivity in humans publication-title: Nutrients – volume: 17 start-page: 935 year: 2020 end-page: 954 ident: bb0755 article-title: Immunotherapies for aging-related neurodegenerative diseases-emerging perspectives and new targets publication-title: Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics. – volume: 21 year: 2020 ident: bb1125 article-title: The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression publication-title: Int. J. Mol. Sci. – volume: 2013 year: 2013 ident: bb0445 article-title: Blockade of airway inflammation by kaempferol via disturbing Tyk-STAT signaling in airway epithelial cells and in asthmatic mice publication-title: Evidence-based Complementary and Alternative Medicine: eCAM. – volume: 21 start-page: 323 year: 2019 end-page: 330 ident: bb0850 article-title: Role of aqueous extract of the wood ear mushroom, Auricularia polytricha (Agaricomycetes), in avoidance of haloperidol-lnduced catalepsy via oxidative stress in rats publication-title: Int J Med Mushrooms. – volume: 9 year: 2020 ident: bb0170 article-title: Potential protective role exerted by secoiridoids from Olea europaea L. in cancer, cardiovascular, neurodegenerative, aging-related, and immunoinflammatory diseases publication-title: Antioxidants (Basel, Switzerland) – volume: 34 year: 2020 ident: bb0550 article-title: Anticomplement and antitussive activities of major compound extracted from Chimonanthus nitens Oliv. leaf publication-title: Biomedical Chromatography: BMC. – volume: 19 start-page: 104 year: 2012 ident: bb1235 article-title: Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates publication-title: J. Biomed. Sci. – volume: 2022 year: 2022 ident: bb1575 article-title: Molecular mechanism investigation on monomer kaempferol of the traditional medicine Dingqing tablet in promoting apoptosis of acute myeloid leukemia HL-60 cells publication-title: Evidence-Based Complementary and Alternative Medicine: eCAM. – volume: 11 start-page: 595 year: 2010 end-page: 621 ident: bb0485 article-title: The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway publication-title: Int. J. Mol. Sci. – volume: 191 start-page: 432 year: 2021 end-page: 444 ident: bb1220 article-title: Current update on psyllium and alginate incorporate for interpenetrating polymer network (IPN) and their biomedical applications publication-title: Int. J. Biol. Macromol. – volume: 31 year: 2017 ident: bb1340 article-title: Endothelial mitochondria regulate local calcium signalling in mesenteric arteries from mice publication-title: FASEB J. – volume: 2019 year: 2019 ident: bb0370 article-title: Beneficial role of phytochemicals on oxidative stress and age-related diseases publication-title: Biomed. Res. Int. – volume: 2013 year: 2013 ident: bb0535 article-title: Nrf2 and cardiovascular defense publication-title: Oxidative Med. Cell. Longev. – volume: 54 start-page: 3738 year: 2013 end-page: 3750 ident: bb0165 article-title: Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 99 start-page: 156 year: 2006 end-page: 164 ident: bb0945 article-title: Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress publication-title: Circ. Res. – volume: 11 year: 2022 ident: bb0950 article-title: Phytochemical composition of different botanical parts of Morus species, health benefits and application in food industry publication-title: Plants (Basel, Switzerland) – volume: 58 start-page: 2832 year: 2017 end-page: 2842 ident: bb0870 article-title: Cellular senescence is associated with human retinal microaneurysm formation during aging publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 102 year: 2023 ident: bb1555 article-title: Understanding the molecular mechanism of Ginkgo Folium-Forsythiae Fructus for cerebral atherosclerosis treatment using network pharmacology and molecular docking publication-title: Medicine – volume: 17 year: 2010 ident: bb0060 article-title: Medicinal plants with antioxidant properties from Banat region (Romania): a rich pool for the discovery of multi-target phytochemicals active in free-radical related disorders publication-title: Analele Universitatii din Oradea-Fascicula Biologie. – volume: 28 start-page: 173 year: 2003 end-page: 177 ident: bb1390 article-title: Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets publication-title: Eur. J. Drug Metab. Pharmacokinet. – volume: 19 start-page: 529 year: 2023 end-page: 548 ident: bb1260 article-title: Phytochemistry and pharmacological profile of drumstick tree “Moringa oleifera lam”: an overview publication-title: Curr. Nutr. Food Sci. – volume: 12 year: 2023 ident: bb0070 article-title: Beyond diabetes management: unraveling metformin's long-term effects on vitamin B12 publication-title: Clin. Diabetol. – volume: 11 start-page: 298 year: 2011 end-page: 344 ident: bb0155 article-title: A review on the dietary flavonoid kaempferol publication-title: Mini-Rev. Med. Chem. – volume: 320 start-page: C465 year: 2021 end-page: c482 ident: bb0025 article-title: Molecular nature and physiological role of the mitochondrial calcium uniporter channel publication-title: Am. J. Phys. Cell Phys. – volume: 40 start-page: 440 year: 2017 end-page: 443 ident: bb0670 article-title: Diabetes and aging: unique considerations and goals of care publication-title: Diabetes Care – volume: 56 start-page: 2281 year: 2008 end-page: 2290 ident: bb0510 article-title: Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH) publication-title: J. Agric. Food Chem. – volume: 1863 start-page: 2307 year: 2017 end-page: 2318 ident: bb1425 article-title: Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: therapeutical effects of kaempferol publication-title: Biochimica et Biophysica Acta Molecular Basis of Disease – volume: 70 start-page: 1098 year: 2021 end-page: 1116 ident: bb0955 article-title: Unique human and mouse β-cell senescence-associated secretory phenotype (SASP) reveal conserved signaling pathways and heterogeneous factors publication-title: Diabetes – volume: 8 year: 2018 ident: bb1160 article-title: Antioxidants: positive or negative actors? publication-title: Biomolecules – volume: 15 start-page: 1779 year: 2021 end-page: 1795 ident: bb0830 article-title: Integrating network pharmacology and experimental validation to decipher the mechanism of action of Huanglian Jiedu decoction in treating atherosclerosis publication-title: Drug Des. Devel. Ther. – volume: 39 start-page: 80 year: 2023 end-page: 85 ident: bb1010 article-title: Kaempferol protects against retinal photoreceptor degeneration in a mouse model of light-induced retinal injury publication-title: Journal of Ocular Pharmacology and Therapeutics: The Official Journal of the Association for Ocular Pharmacology and Therapeutics. – volume: 12 start-page: 383 year: 1997 end-page: 390 ident: bb1255 article-title: Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol publication-title: Mutagenesis – volume: 248 start-page: 953 year: 1987 end-page: 956 ident: bb0130 article-title: Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans publication-title: Biochem. J. – volume: 40 start-page: 2408 year: 2020 end-page: 2424 ident: bb0280 article-title: Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 23 year: 2022 ident: bb0605 article-title: Investigation of the molecular mechanisms underlying the antiatherogenic actions of kaempferol in human THP-1 macrophages publication-title: Int. J. Mol. Sci. – volume: 56 start-page: 105 year: 2015 end-page: 113 ident: bb0920 article-title: Blue LED light enhances growth, phytochemical contents, and antioxidant enzyme activities of Rehmannia glutinosa cultured in vitro publication-title: Hortic. Environ. Biotechnol. – volume: 8 start-page: 2189 year: 2018 ident: bb0010 article-title: Kaempferol mitigates endoplasmic reticulum stress induced cell death by targeting caspase 3/7 publication-title: Sci. Rep. – volume: 19 start-page: 627 year: 2020 end-page: 634 ident: bb0695 article-title: Recent studies on kaempferol and its biological and pharmacological activities publication-title: EXCLI J. – volume: 7 start-page: 861 year: 2016 end-page: 871 ident: bb1270 article-title: Bioefficacy of Graviola leaf extracts in scavenging free radicals and upregulating antioxidant genes publication-title: Food Funct. – volume: 6 year: 2011 ident: bb0460 article-title: Short telomeres compromise β-cell signaling and survival publication-title: PLoS One – volume: 2022 year: 2022 ident: bb1150 article-title: Protective effect of kaempferol and its nanoparticles on 5-fluorouracil-induced cardiotoxicity in rats publication-title: Biomed. Res. Int. – volume: 86 start-page: 103 year: 2014 end-page: 112 ident: bb1095 article-title: Kaempferol, a potential cytostatic and cure for inflammatory disorders publication-title: Eur. J. Med. Chem. – volume: 46 start-page: 329 year: 2007 end-page: 336 ident: bb0780 article-title: Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds publication-title: Eur. J. Nutr. – volume: 3 start-page: 119 year: 2013 end-page: 124 ident: bb1370 article-title: Nephro-protective significance of kaempferol on mercuric chloride induced toxicity in Wistar albino rats publication-title: Biomedicine & Aging Pathology. – volume: 47 start-page: 3764 year: 1999 end-page: 3770 ident: bb0530 article-title: Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS publication-title: J. Agric. Food Chem. – volume: 776 start-page: 31 year: 2015 end-page: 39 ident: bb0765 article-title: The impact of base excision DNA repair in age-related neurodegenerative diseases publication-title: Mutat. Res. – volume: 2013 year: 2013 ident: bb1375 article-title: Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro publication-title: Oxidative Med. Cell. Longev. – volume: 47 start-page: 2274 year: 1999 end-page: 2279 ident: bb0480 article-title: Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries publication-title: J. Agric. Food Chem. – volume: 4 start-page: 331 year: 2005 end-page: 344 ident: bb1420 article-title: Osteoarthritis - an untreatable disease? publication-title: Nat. Rev. Drug Discov. – volume: 11 year: 2020 ident: bb1245 article-title: The pharmacological action of kaempferol in central nervous system diseases: a review publication-title: Front. Pharmacol. – volume: 176 start-page: 19 year: 2018 end-page: 23 ident: bb0365 article-title: Caloric restriction and cellular senescence publication-title: Mech. Ageing Dev. – volume: 63 start-page: 1035 year: 2000 end-page: 1042 ident: bb1070 article-title: Flavonoids as antioxidants publication-title: J. Nat. Prod. – volume: 10 start-page: 263 year: 2011 end-page: 276 ident: bb0265 article-title: Age-related alterations in the dynamic behavior of microglia publication-title: Aging Cell – year: 2018 ident: bb0420 article-title: Anti-aging Effects of Sulfur-containing Amino Acids and Nutraceuticals – volume: 49 start-page: 11101 year: 2022 end-page: 11111 ident: bb0035 article-title: Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders publication-title: Mol. Biol. Rep. – volume: 384 start-page: 19 year: 2004 end-page: 24 ident: bb0980 article-title: Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids publication-title: Biochem. J. – volume: 69 start-page: 1113 year: 2017 end-page: 1119 ident: bb1020 article-title: Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia publication-title: Pharmacological Reports: PR. – volume: 15 start-page: 167 year: 2009 end-page: 172 ident: bb1345 article-title: Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats publication-title: Nat. Prod. Sci. – volume: 61 start-page: 11033 year: 2013 end-page: 11040 ident: bb0110 article-title: Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans publication-title: J. Agric. Food Chem. – volume: 20 start-page: 4813 year: 2015 end-page: 4832 ident: bb0975 article-title: In vitro neuroprotective activities of compounds from Angelica shikokiana Makino publication-title: Molecules (Basel, Switzerland). – volume: 13 year: 2023 ident: bb0440 article-title: Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing publication-title: Front. Oncol. – volume: 50 start-page: 246 year: 2018 end-page: 253 ident: bb0800 article-title: Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO publication-title: Acta Biochim. Biophys. Sin. – volume: 164 start-page: 1008 year: 2011 end-page: 1025 ident: bb1050 article-title: Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells publication-title: Br. J. Pharmacol. – volume: 32 start-page: 971 year: 2013 end-page: 977 ident: bb1500 article-title: Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs publication-title: Int. J. Mol. Med. – volume: 25 start-page: 974 year: 1994 end-page: 988 ident: bb1265 article-title: Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells publication-title: J. Neurobiol. – volume: 234 start-page: 295 year: 2014 end-page: 302 ident: bb1180 article-title: Endothelial microparticles as conveyors of information in atherosclerotic disease publication-title: Atherosclerosis – volume: 17 start-page: 421 year: 2018 end-page: 429 ident: bb0095 article-title: Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer's disease publication-title: CNS Neurol. Disord. Drug Targets – volume: 106 start-page: 175 year: 2017 end-page: 184 ident: bb0310 article-title: Chemically characterized Mentha cardiaca L. essential oil as plant based preservative in view of efficacy against biodeteriorating fungi of dry fruits, aflatoxin secretion, lipid peroxidation and safety profile assessment publication-title: Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. – year: 2023 ident: bb1115 article-title: Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower. bioRxiv:2023.2006. 2022.546132 – volume: 141 start-page: 810 year: 2012 end-page: 816 ident: bb0470 article-title: Sedative, antiepileptic and antipsychotic effects of publication-title: J. Ethnopharmacol. – volume: 281 start-page: 37102 year: 2006 end-page: 37110 ident: bb0880 article-title: Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism publication-title: J. Biol. Chem. – volume: 58 start-page: 140 year: 2006 end-page: 161 ident: bb0260 article-title: Multidrug resistance-associated proteins: expression and function in the central nervous system publication-title: Pharmacol. Rev. – volume: 37 year: 2023 ident: bb0590 article-title: From nature to therapy: luteolin’s potential as an immune system modulator in inflammatory disorders publication-title: J. Biochem. Mol. Toxicol. – volume: 8 year: 2021 ident: bb0965 article-title: Memorable food: fighting age-related neurodegeneration by precision nutrition publication-title: Front. Nutr. – volume: 169 start-page: 787 year: 2015 end-page: 788 ident: bb0285 article-title: Association between long telomere length and insulin sensitization in adolescent girls with hyperinsulinemic androgen excess publication-title: JAMA Pediatr. – volume: 118 start-page: 3272 year: 2023 end-page: 3287 ident: bb1170 article-title: Global burden of heart failure: a comprehensive and updated review of epidemiology publication-title: Cardiovasc. Res. – volume: 33 start-page: 1065 year: 2019 end-page: 1073 ident: bb1475 article-title: Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway publication-title: Phytotherapy Research: PTR. – volume: 8 start-page: 82 year: 2022 ident: bb1585 article-title: A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease publication-title: NPJ Parkinson's Disease. – volume: 161 year: 2020 ident: bb1540 article-title: The endoplasmic reticulum and calcium homeostasis in pancreatic beta cells publication-title: Endocrinology – volume: 32 start-page: 133 year: 2009 end-page: 138 ident: bb0790 article-title: Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats publication-title: Arch. Pharm. Res. – volume: 7 start-page: 23 year: 2008 end-page: 31 ident: bb1075 article-title: Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis publication-title: Aging Cell – volume: 445 start-page: 656 year: 2007 end-page: 660 ident: bb1470 article-title: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas publication-title: Nature – volume: 209 start-page: 114 year: 2005 end-page: 122 ident: bb1000 article-title: Protective and detrimental effects of kaempferol in rat H4IIE cells: implication of oxidative stress and apoptosis publication-title: Toxicol. Appl. Pharmacol. – volume: 58 start-page: 947 year: 2004 end-page: 954 ident: bb0305 article-title: Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans publication-title: Eur. J. Clin. Nutr. – volume: 7 year: 2012 ident: bb0395 article-title: Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation publication-title: PLoS One – volume: 11 start-page: 36 year: 2017 end-page: 41 ident: bb0905 article-title: Anti-psychotic activity of aqueous root extract of Hemidesmus indicus: a time bound study in rats publication-title: Recent Pat. Drug Deliv. Formul. – volume: 189 start-page: 186 year: 2016 end-page: 193 ident: bb1290 article-title: Ethnobotanical uses of neem (Azadirachta indica A. Juss.; Meliaceae) leaves in Bali (Indonesia) and the Indian subcontinent in relation with historical background and phytochemical properties publication-title: J. Ethnopharmacol. – volume: 15 year: 2023 ident: bb1415 article-title: Natural phytochemicals as SIRT activators-focus on potential biochemical mechanisms publication-title: Nutrients – volume: 23 start-page: 775 year: 2017 end-page: 781 ident: bb0625 article-title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment publication-title: Nat. Med. – volume: 128 start-page: 492 year: 2021 end-page: 507 ident: bb0205 article-title: Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway publication-title: Circ. Res. – volume: 23 start-page: 1072 year: 2017 end-page: 1079 ident: bb0335 article-title: Targeting cellular senescence prevents age-related bone loss in mice publication-title: Nat. Med. – volume: 121 start-page: 369 year: 2011 end-page: 383 ident: bb1560 article-title: mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice publication-title: J. Clin. Invest. – volume: 42 start-page: 1 year: 2023 end-page: 16 ident: bb1130 article-title: Exploring the mechanical perspective of a new anti-tumor agent: melatonin publication-title: Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer. – volume: 25 year: 2020 ident: bb1085 article-title: Mechanisms of aging and the preventive effects of resveratrol on age-related diseases publication-title: Molecules (Basel, Switzerland) – volume: 81 start-page: 849 year: 2007 end-page: 858 ident: bb0675 article-title: Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans publication-title: Arch. Toxicol. – volume: 37 start-page: 199 year: 2018 end-page: 208 ident: bb0300 article-title: Herbal medicines in neurodegenerative disorders: an evolutionary approach through novel drug delivery system publication-title: Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer. – volume: 92 start-page: 240 year: 2017 end-page: 248 ident: bb0450 article-title: Justicia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural products publication-title: Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. – volume: 171 start-page: 345 year: 2021 end-page: 364 ident: bb1405 article-title: Redox signaling in heart failure and therapeutic implications publication-title: Free Radic. Biol. Med. – volume: 10 start-page: 1953 year: 1989 end-page: 1955 ident: bb0380 article-title: Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine publication-title: Carcinogenesis – volume: 58 start-page: 620 year: 2010 end-page: 627 ident: bb0775 article-title: Flavonol glycosides of sea buckthorn (Hippophaë rhamnoides ssp. sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion publication-title: J. Agric. Food Chem. – volume: 214 year: 2022 ident: bb1200 article-title: Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases publication-title: Prog. Neurobiol. – volume: 9 start-page: 1798 year: 2018 ident: bb1015 article-title: Exercise, telomeres, and cancer: “the exercise-telomere hypothesis” publication-title: Front. Physiol. – volume: 233 start-page: 284 year: 2019 end-page: 296 ident: bb1025 article-title: Wound healing effect of kaempferol in diabetic and nondiabetic rats publication-title: J. Surg. Res. – volume: 18 year: 2017 ident: bb1285 article-title: Molecular pathways involved in the amelioration of myocardial injury in diabetic rats by kaempferol publication-title: Int. J. Mol. Sci. – volume: 46 year: 2022 ident: bb0545 article-title: Kaempferol-3-O-rutinoside exerts cardioprotective effects through NF-κB/NLRP3/Caspase-1 pathway in ventricular remodeling after acute myocardial infarction publication-title: J. Food Biochem. – volume: 23 year: 2022 ident: bb1410 article-title: Cellular and gene expression response to the combination of genistein and kaempferol in the treatment of mucopolysaccharidosis type I publication-title: Int. J. Mol. Sci. – volume: 1722 year: 2019 ident: bb0810 article-title: Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats publication-title: Brain Res. – volume: 69 start-page: 681 year: 2022 end-page: 687 ident: bb0570 article-title: A review of the Phyllanthus genus plants: their phytochemistry, traditional uses, and potential inhibition of xanthine oxidase publication-title: Pharmacia – volume: 3 start-page: 175 year: 2002 end-page: 187 ident: bb0990 article-title: Neopterin as a marker for immune system activation publication-title: Curr. Drug Metab. – volume: 7 year: 2017 ident: bb0115 article-title: Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations publication-title: Transl. Psychiatry – volume: 66 start-page: 2201 year: 2014 end-page: 2209 ident: bb0860 article-title: Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1 publication-title: Arthritis & Rheumatology (Hoboken, NJ). – volume: 25 year: 2020 ident: bb0020 article-title: Kaempferol as a dietary anti-inflammatory agent: current therapeutic standing publication-title: Molecules (Basel, Switzerland) – volume: 47 start-page: 2196 year: 2009 end-page: 2201 ident: bb1360 article-title: In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves publication-title: Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. – volume: 87 start-page: 584 year: 2021 end-page: 599 ident: bb0315 article-title: Artemisia annua - importance in traditional medicine and current state of knowledge on the chemistry, biological activity and possible applications publication-title: Planta Med. – volume: 19 start-page: 313 year: 2023 end-page: 323 ident: bb0620 article-title: Identification of kaempferol as viral entry inhibitor and DL-arginine as viral replication inhibitor from selected plants of Indian traditional medicine against COVID-19: an in silico guided in vitro approach publication-title: Curr. Comput. Aided Drug Des. – volume: 22 start-page: 340 year: 2022 end-page: 355 ident: bb1400 article-title: Exploiting senescence for the treatment of cancer publication-title: Nat. Rev. Cancer – volume: 2018 year: 2018 ident: bb0295 article-title: Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage publication-title: Oxidative Med. Cell. Longev. – volume: 249 year: 2023 ident: bb0580 article-title: Long non-coding RNAs in lung cancer: unraveling the molecular modulators of MAPK signaling publication-title: Pathol. Res. Pract. – volume: 41 start-page: 1198 year: 2016 end-page: 1203 ident: bb0795 article-title: Biopharmaceutics classification and absorption mechanisms primary study on four kinds of flavonoids publication-title: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China J. Chin. Mater. Med. – volume: 432 start-page: 1514 year: 2020 end-page: 1534 ident: bb0885 article-title: Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes publication-title: J. Mol. Biol. – volume: 72 start-page: 40 year: 2022 end-page: 50 ident: bb0575 article-title: The burden of cardiovascular diseases due to COVID-19 pandemic publication-title: Thorac. Cardiovasc. – volume: 78 start-page: 140 year: 2005 end-page: 146 ident: bb1455 article-title: Absorption and enterohepatic circulation of baicalin in rats publication-title: Life Sci. – volume: 29 start-page: 63369 year: 2022 end-page: 63378 ident: bb0600 article-title: Ruthana date extract inhibited proliferation of human hepatocellular carcinoma (HepG2) cells by modulation of BAX gene publication-title: Environ. Sci. Pollut. Res. Int. – volume: 36 start-page: S123 year: 1984 end-page: S128 ident: bb1045 article-title: Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences publication-title: Calcif. Tissue Int. – volume: 18 start-page: 675 year: 2023 end-page: 678 ident: bb0475 article-title: Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19 publication-title: Regen. Med. – volume: 5 start-page: 265 year: 2017 end-page: 279 ident: bb0680 article-title: Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β-glucuronidase in macrophages publication-title: Immunity, Inflammation and Disease. – volume: 16 start-page: 270 year: 2019 ident: bb0465 article-title: Association of LAG3 genetic variation with an increased risk of PD in Chinese female population publication-title: J. Neuroinflammation – volume: 33 start-page: 823 year: 2021 end-page: 834 ident: bb0100 article-title: Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders publication-title: Aging Clin. Exp. Res. – volume: 15 start-page: 1860 year: 2019 end-page: 1881 ident: bb0490 article-title: Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease publication-title: Autophagy – volume: 128 start-page: 44 year: 2017 end-page: 54 ident: bb0855 article-title: The role of aging in the development of osteoarthritis publication-title: Trans. Am. Clin. Climatol. Assoc. – volume: 9 start-page: 303 year: 2014 end-page: 314 ident: bb1295 article-title: The role of microparticles in chronic obstructive pulmonary disease publication-title: Int. J. Chron. Obstruct. Pulmon. Dis. – volume: 54 start-page: 818 year: 2006 end-page: 831 ident: bb0255 article-title: Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis publication-title: Arthritis Rheum. – volume: 72 start-page: 303 year: 2016 end-page: 313 ident: bb1435 article-title: Kaempferol inhibits the production of ROS to modulate OPN-αvβ3 integrin pathway in HUVECs publication-title: J. Physiol. Biochem. – volume: 20 start-page: 18031 year: 2015 end-page: 18046 ident: bb0940 article-title: Plasma pharmacokinetics of polyphenols in a traditional Japanese medicine, jumihaidokuto, which suppresses Propionibacterium acnes-induced dermatitis in rats publication-title: Molecules (Basel, Switzerland). – volume: 103 start-page: 1860 year: 1978 end-page: 1867 ident: bb0925 article-title: Phytoestrogen interaction with estrogen receptors in human breast cancer cells publication-title: Endocrinology – volume: 74 year: 2020 ident: bb1035 article-title: Antioxidant, anti-inflammatory and neuroprotective effect of kaempferol on rotenone-induced Parkinson’s disease model of rats and SH-S5Y5 cells by preventing loss of tyrosine hydroxylase publication-title: J. Funct. Foods – volume: 38 year: 2019 ident: bb0055 article-title: Length-independent telomere damage drives post-mitotic cardiomyocyte senescence publication-title: EMBO J. – volume: 26 start-page: 1120 year: 2003 end-page: 1124 ident: bb1495 article-title: Glucurono- and sulfo-conjugation of kaempferol in rat liver subcellular preparations and cultured hepatocytes publication-title: Biol. Pharm. Bull. – volume: 26 start-page: 993 year: 2018 end-page: 1003 ident: bb0710 article-title: Effect of Kaempferol isolated from seeds of Eruca sativa on changes of pain sensitivity in Streptozotocin-induced diabetic neuropathy publication-title: Inflammopharmacology – year: 2017 ident: bb1165 article-title: Flavonoids: Classification, Biosynthesis and Chemical Ecology: IntechOpen – volume: 9 year: 2021 ident: bb1600 article-title: Targeting the mitochondria-proteostasis axis to delay aging publication-title: Frontiers in Cell and Developmental Biology. – volume: 249 year: 2023 ident: bb0585 article-title: Probing the links: long non-coding RNAs and NF-κB signalling in atherosclerosis publication-title: Pathol. Res. Pract. – volume: 77 start-page: 789 year: 2020 end-page: 805 ident: bb0125 article-title: Senescence in the pathogenesis of age-related macular degeneration publication-title: Cellular and Molecular Life Sciences: CMLS. – volume: 2015 year: 2015 ident: bb0705 article-title: The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets publication-title: Mediat. Inflamm. – volume: 99 start-page: 2771 year: 2014 end-page: 2777 ident: bb1310 article-title: β-Cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length publication-title: J. Clin. Endocrinol. Metab. – volume: 79 start-page: 1565 year: 2013 end-page: 1571 ident: bb0385 article-title: Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology publication-title: Planta Med. – volume: 25 start-page: 408 year: 2008 end-page: 422 ident: bb0325 article-title: Treatment options in Alzheimer’s disease: maximizing benefit, managing expectations publication-title: Dement. Geriatr. Cogn. Disord. – volume: 17 start-page: 549 year: 2013 end-page: 561 ident: bb1195 article-title: Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration publication-title: Cell Metab. – volume: 47 year: 2021 ident: bb1520 article-title: Advanced oxidation protein products aggravate age-related bone loss by increasing sclerostin expression in osteocytes via ROS-dependent downregulation of Sirt1 publication-title: Int. J. Mol. Med. – volume: 173 start-page: 71 year: 2000 end-page: 75 ident: bb1190 article-title: Anaerobic degradation of flavonoids by Eubacterium ramulus publication-title: Arch. Microbiol. – volume: 27 start-page: 6164 year: 2022 ident: bb1105 article-title: Andrographis paniculata dosage forms and advances in nanoparticulate delivery systems: an overview publication-title: Molecules (Basel, Switzerland) – volume: 83 start-page: 837 year: 2017 end-page: 845 ident: bb0340 article-title: Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress publication-title: Planta Med. – volume: 2022 year: 2022 ident: bb1320 article-title: Research on the mechanism of Kaempferol for treating senile osteoporosis by network pharmacology and molecular docking publication-title: Evidence-based Complementary and Alternative Medicine: eCAM. – volume: 15 year: 2018 ident: bb1590 article-title: Quercetin, kaempferol and isorhamnetin in Elaeagnus pungens Thunb. leaf: pharmacological activities and quantitative determination studies publication-title: Chem. Biodivers. – volume: 8 start-page: 373 year: 2014 ident: bb1280 article-title: De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus publication-title: Front. Cell. Neurosci. – volume: 72 year: 2020 ident: bb0815 article-title: Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat publication-title: J. Funct. Foods – volume: 11 year: 2022 ident: bb0820 article-title: Sirtuin 3 plays a critical role in the antidepressant- and anxiolytic-like effects of kaempferol publication-title: Antioxidants (Basel, Switzerland) – volume: 31 start-page: 1920 year: 2016 end-page: 1929 ident: bb0330 article-title: Identification of senescent cells in the bone microenvironment publication-title: J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. – volume: 8 start-page: 628 year: 2017 end-page: 642 ident: bb0065 article-title: The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks publication-title: Aging Dis. – volume: 2013 year: 2013 ident: bb0745 article-title: Chemistry and biological activities of flavonoids: an overview publication-title: Sci. World J. – volume: 108 start-page: 741 year: 2012 end-page: 757 ident: bb1080 article-title: Pharmacoresistance publication-title: Handb. Clin. Neurol. – volume: 15 start-page: 203 year: 2016 end-page: 210 ident: bb1040 article-title: Efficacy of Elaeagnus angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial publication-title: EXCLI J. – volume: 10 start-page: 256 year: 2009 end-page: 271 ident: bb1355 article-title: Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways publication-title: Curr. Drug Metab. – volume: 284 start-page: G980 year: 2003 end-page: G988 ident: bb0245 article-title: The splanchnic metabolism of flavonoids highly differed according to the nature of the compound publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. – volume: 129 start-page: 1203 year: 2019 end-page: 1212 ident: bb1515 article-title: Intracerebroventricular microinjection of kaempferol on memory retention of passive avoidance learning in rats: involvement of cholinergic mechanism(s) publication-title: Int. J. Neurosci. – volume: 153 start-page: 1194 year: 2013 end-page: 1217 ident: bb0875 article-title: The hallmarks of aging publication-title: Cell – volume: 670 start-page: 325 year: 2011 end-page: 332 ident: bb1525 article-title: Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function publication-title: Eur. J. Pharmacol. – volume: 19 start-page: 105 year: 2023 end-page: 113 ident: bb0750 article-title: An overview of treatment modalities and management aspects for obesity publication-title: Curr. Nutr. Food Sci. – volume: 55 year: 2019 ident: bb0685 article-title: From pre-diabetes to diabetes: diagnosis, treatments and translational research publication-title: Medicina (Kaunas, Lithuania) – volume: 54 start-page: 297 year: 1978 end-page: 309 ident: bb0900 article-title: Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium publication-title: Mutat. Res. – volume: 11 start-page: 5427 year: 2023 end-page: 5437 ident: bb0015 article-title: A randomized, placebo-controlled trial evaluating the safety of excessive administration of kaempferol aglycone publication-title: Food Sci. Nutr. – volume: 6 start-page: 354 year: 2021 ident: bb1440 article-title: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src publication-title: Signal Transduct. Target. Ther. – volume: 89 start-page: 4668 year: 1992 end-page: 4672 ident: bb1335 article-title: Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain publication-title: Proc. Natl. Acad. Sci. USA – volume: 46 start-page: 622 year: 2011 end-page: 630 ident: bb1580 article-title: Advances in the structure-activity relationship study of natural flavonoids and its derivatives publication-title: Yao Xue Xue Bao = Acta Pharm. Sin. – volume: 11 year: 2019 ident: bb0275 article-title: Maternal flavonoids intake reverts depression-like behaviour in rat female offspring publication-title: Nutrients – year: 2023 ident: bb0400 article-title: Exploring the therapeutic potential of naturally occurring piceatannol in non-communicable diseases publication-title: BioFactors (Oxford, England) – volume: 22 year: 2020 ident: bb1100 article-title: Kaempferol inhibits zearalenone-induced oxidative stress and apoptosis via the PI3K/Akt-mediated Nrf2 signaling pathway: in vitro and in vivo studies publication-title: Int. J. Mol. Sci. – volume: 49 start-page: 1603 year: 2010 end-page: 1616 ident: bb1120 article-title: Oxidative stress, inflammation, and cancer: how are they linked? publication-title: Free Radic. Biol. Med. – volume: 57 start-page: 5910 year: 2016 end-page: 5918 ident: bb0150 article-title: Senescence increases choroidal endothelial stiffness and susceptibility to complement injury: implications for Choriocapillaris loss in AMD publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 12 year: 2020 ident: bb0105 article-title: Targeting mitochondrial calcium uptake with the natural flavonol kaempferol, to promote metabolism/secretion coupling in pancreatic β-cells publication-title: Nutrients – volume: 57 start-page: 399 year: 1999 end-page: 404 ident: bb1135 article-title: Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity publication-title: J. Neurosci. Res. – volume: 13 start-page: 89 year: 2023 end-page: 95 ident: bb0075 article-title: Chronic calcific pancreatitis and its association with secondary diabetes mellitus publication-title: Journal of Endocrinology and Metabolism. – volume: 58 start-page: 261 year: 2007 end-page: 269 ident: bb0135 article-title: Urinary excretion of kaempferol from common beans (Phaseolus vulgaris L.) in humans publication-title: Int. J. Food Sci. Nutr. – volume: 68 start-page: 476 year: 2016 end-page: 532 ident: bb0145 article-title: Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders publication-title: Pharmacol. Rev. – volume: 23 year: 2022 ident: bb0660 article-title: Chrysin induces apoptosis via the MAPK pathway and regulates ERK/mTOR-mediated autophagy in MC-3 cells publication-title: Int. J. Mol. Sci. – volume: 371 start-page: 265 year: 2021 end-page: 270 ident: bb0655 article-title: Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders publication-title: Science (New York, N.Y.) – volume: 63 year: 2016 ident: bb1175 article-title: Neurodegeneration in accelerated aging publication-title: Dan. Med. J. – volume: 7 start-page: 31 year: 2011 end-page: 40 ident: bb1365 article-title: The role of inflammation in epilepsy publication-title: Nat. Rev. Neurol. – volume: 13 start-page: 1451 year: 2021 end-page: 1464 ident: bb1445 article-title: Kaempferol attenuates the effects of XIST/miR-130a/STAT3 on inflammation and extracellular matrix degradation in osteoarthritis publication-title: Future Med. Chem. – volume: 60 start-page: S107 year: 2017 end-page: s131 ident: bb0350 article-title: The DNA damage response in neurons: die by apoptosis or survive in a senescence-like state? publication-title: Journal of Alzheimer’s disease : JAD. – volume: 12 year: 2021 ident: bb1450 article-title: Kaempferol ameliorates the inhibitory activity of dexamethasone in the osteogenesis of MC3T3-E1 cells by JNK and p38-MAPK pathways publication-title: Front. Pharmacol. – volume: 22 start-page: 2474 year: 2022 end-page: 2482 ident: bb1205 article-title: Anticancer properties of kaempferol on cellular signaling pathways publication-title: Curr. Top. Med. Chem. – volume: 34 start-page: 485 year: 2019 end-page: 494 ident: bb0405 article-title: Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade publication-title: Metab. Brain Dis. – volume: 28 start-page: 1214 year: 2013 end-page: 1228 ident: bb0195 article-title: DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism publication-title: Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research. – volume: 14 start-page: 5576 year: 2017 end-page: 5582 ident: bb1430 article-title: Kaempferol targets estrogen-related receptor α and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions publication-title: Exp. Ther. Med. – volume: 62 start-page: 1835 year: 2019 end-page: 1841 ident: bb1030 article-title: Cellular senescence: at the nexus between ageing and diabetes publication-title: Diabetologia – volume: 32 start-page: 197 year: 2010 end-page: 208 ident: bb0700 article-title: Kaempferol modulates pro-inflammatory NF-kappaB activation by suppressing advanced glycation endproducts-induced NADPH oxidase publication-title: Age (Dordr.) – volume: 17 start-page: 935 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0755 article-title: Immunotherapies for aging-related neurodegenerative diseases-emerging perspectives and new targets publication-title: Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics. doi: 10.1007/s13311-020-00853-2 – volume: 40 start-page: 440 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0670 article-title: Diabetes and aging: unique considerations and goals of care publication-title: Diabetes Care doi: 10.2337/dci17-0005 – volume: 18 start-page: 97 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0985 article-title: The endocannabinoid system may modulate sleep disorders in aging publication-title: Curr. Neuropharmacol. doi: 10.2174/1570159X17666190801155922 – volume: 16 start-page: 229 year: 1996 ident: 10.1016/j.exger.2024.112389_bb1250 article-title: Mutagenicity of kaempferol in V79 cells: the role of cytochromes P450 publication-title: Teratog. Carcinog. Mutagen. doi: 10.1002/(SICI)1520-6866(1996)16:4<229::AID-TCM4>3.0.CO;2-K – volume: 47 start-page: 3764 year: 1999 ident: 10.1016/j.exger.2024.112389_bb0530 article-title: Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS publication-title: J. Agric. Food Chem. doi: 10.1021/jf9902651 – volume: 14 start-page: 218 year: 1993 ident: 10.1016/j.exger.2024.112389_bb0890 article-title: Second peak of plasma diazepam concentration and enterogastric circulation publication-title: Zhongguo Yao Li Xue Bao = Acta Pharmacol. Sin. – volume: 69 start-page: 1113 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1020 article-title: Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia publication-title: Pharmacological Reports: PR. doi: 10.1016/j.pharep.2017.05.002 – volume: 76 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1230 article-title: Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: an in vitro and in vivo study in diabetic nephropathy mice model publication-title: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. doi: 10.1016/j.phymed.2020.153235 – volume: 58 start-page: 2832 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0870 article-title: Cellular senescence is associated with human retinal microaneurysm formation during aging publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-20312 – volume: 59 start-page: amd83 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0235 article-title: A perspective of AMD through the eyes of immunology publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.18-23893 – volume: 35 start-page: 2645 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0665 article-title: Kaempferol is an anti-inflammatory compound with activity towards NF-κB pathway proteins publication-title: Anticancer Res. – volume: 103 start-page: 249 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0160 article-title: The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake publication-title: Br. J. Nutr. doi: 10.1017/S000711450999170X – volume: 6 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1110 article-title: Neuroprotective effects of a standardized flavonoid extract of safflower against neurotoxin-induced cellular and animal models of Parkinson’s disease publication-title: Sci. Rep. – volume: 15 start-page: 203 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1040 article-title: Efficacy of Elaeagnus angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial publication-title: EXCLI J. – volume: 47 start-page: 2274 year: 1999 ident: 10.1016/j.exger.2024.112389_bb0480 article-title: Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries publication-title: J. Agric. Food Chem. doi: 10.1021/jf9811065 – volume: 11 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1245 article-title: The pharmacological action of kaempferol in central nervous system diseases: a review publication-title: Front. Pharmacol. – volume: 5 start-page: 265 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0680 article-title: Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β-glucuronidase in macrophages publication-title: Immunity, Inflammation and Disease. doi: 10.1002/iid3.163 – volume: 11 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0820 article-title: Sirtuin 3 plays a critical role in the antidepressant- and anxiolytic-like effects of kaempferol publication-title: Antioxidants (Basel, Switzerland) – volume: 153 start-page: 707 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1535 article-title: Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease publication-title: Cell doi: 10.1016/j.cell.2013.03.030 – volume: 432 start-page: 1514 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0885 article-title: Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2019.09.016 – volume: 25 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0020 article-title: Kaempferol as a dietary anti-inflammatory agent: current therapeutic standing publication-title: Molecules (Basel, Switzerland) doi: 10.3390/molecules25184073 – volume: 14 start-page: R12 year: 2012 ident: 10.1016/j.exger.2024.112389_bb0500 article-title: The distribution pattern of critically short telomeres in human osteoarthritic knees publication-title: Arthritis Res. Ther. doi: 10.1186/ar3687 – volume: 26 start-page: 993 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0710 article-title: Effect of Kaempferol isolated from seeds of Eruca sativa on changes of pain sensitivity in Streptozotocin-induced diabetic neuropathy publication-title: Inflammopharmacology doi: 10.1007/s10787-017-0416-2 – volume: 20 start-page: 18031 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0940 article-title: Plasma pharmacokinetics of polyphenols in a traditional Japanese medicine, jumihaidokuto, which suppresses Propionibacterium acnes-induced dermatitis in rats publication-title: Molecules (Basel, Switzerland). doi: 10.3390/molecules201018031 – volume: 18 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1285 article-title: Molecular pathways involved in the amelioration of myocardial injury in diabetic rats by kaempferol publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms18051001 – volume: 18 start-page: 283 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1565 article-title: Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.12186 – volume: 72 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0050 article-title: Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1. Journal of physiology and pharmacology : an official journal of the Polish Physiological publication-title: Society – volume: 138 start-page: 2099 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0180 article-title: A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention publication-title: Food Chem. doi: 10.1016/j.foodchem.2012.11.139 – volume: 34 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0550 article-title: Anticomplement and antitussive activities of major compound extracted from Chimonanthus nitens Oliv. leaf publication-title: Biomedical Chromatography: BMC. doi: 10.1002/bmc.4736 – volume: 23 start-page: 775 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0625 article-title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment publication-title: Nat. Med. doi: 10.1038/nm.4324 – volume: 2022 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1575 article-title: Molecular mechanism investigation on monomer kaempferol of the traditional medicine Dingqing tablet in promoting apoptosis of acute myeloid leukemia HL-60 cells publication-title: Evidence-Based Complementary and Alternative Medicine: eCAM. doi: 10.1155/2022/8383315 – volume: 92 start-page: 240 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0450 article-title: Justicia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural products publication-title: Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. doi: 10.1016/j.biopha.2017.05.075 – volume: 34 start-page: 485 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0405 article-title: Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade publication-title: Metab. Brain Dis. doi: 10.1007/s11011-019-0389-5 – volume: 118 start-page: 1173 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0210 article-title: Senescence mechanisms and targets in the heart publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvab161 – volume: 84 start-page: 545 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0230 article-title: Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction publication-title: J. Periodontol. doi: 10.1902/jop.2012.120180 – volume: 35 start-page: 25 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1060 article-title: The role of diazepam in epigenetics: from the molecular level to clinical implications publication-title: Adv. Mind Body Med. – volume: 8 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0120 article-title: Bioactive phytochemicals from Mercurialis spp. used in traditional spanish medicine publication-title: Plants (Basel, Switzerland) – volume: 46 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0545 article-title: Kaempferol-3-O-rutinoside exerts cardioprotective effects through NF-κB/NLRP3/Caspase-1 pathway in ventricular remodeling after acute myocardial infarction publication-title: J. Food Biochem. doi: 10.1111/jfbc.14305 – volume: 86 start-page: 103 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1095 article-title: Kaempferol, a potential cytostatic and cure for inflammatory disorders publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.08.011 – volume: 8 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1505 article-title: Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke publication-title: PLoS One – volume: 8 year: 2018 ident: 10.1016/j.exger.2024.112389_bb1160 article-title: Antioxidants: positive or negative actors? publication-title: Biomolecules doi: 10.3390/biom8040124 – volume: 26 start-page: 210 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0175 article-title: Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium publication-title: Mammalian Genome: Official Journal of the International Mammalian Genome Society. doi: 10.1007/s00335-015-9568-9 – volume: 13 start-page: 1451 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1445 article-title: Kaempferol attenuates the effects of XIST/miR-130a/STAT3 on inflammation and extracellular matrix degradation in osteoarthritis publication-title: Future Med. Chem. doi: 10.4155/fmc-2021-0127 – volume: 10 start-page: 263 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0265 article-title: Age-related alterations in the dynamic behavior of microglia publication-title: Aging Cell doi: 10.1111/j.1474-9726.2010.00660.x – volume: 87 start-page: 584 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0315 article-title: Artemisia annua - importance in traditional medicine and current state of knowledge on the chemistry, biological activity and possible applications publication-title: Planta Med. doi: 10.1055/a-1345-9528 – volume: 19 start-page: 105 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0750 article-title: An overview of treatment modalities and management aspects for obesity publication-title: Curr. Nutr. Food Sci. doi: 10.2174/1573401318666220527124759 – volume: 99 start-page: 156 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0945 article-title: Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress publication-title: Circ. Res. doi: 10.1161/01.RES.0000233315.38086.bc – year: 2023 ident: 10.1016/j.exger.2024.112389_bb1115 – volume: 716 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1570 article-title: Kaempferol protects retinal ganglion ceils from high-glucose-induced injury by regulating vasohibin-1 publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2019.134633 – volume: 3 start-page: 175 year: 2002 ident: 10.1016/j.exger.2024.112389_bb0990 article-title: Neopterin as a marker for immune system activation publication-title: Curr. Drug Metab. doi: 10.2174/1389200024605082 – volume: 94 start-page: 166 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0635 article-title: DNA repair deficiency in neurodegeneration publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2011.04.013 – volume: 32 start-page: 971 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1500 article-title: Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2013.1468 – year: 2021 ident: 10.1016/j.exger.2024.112389_bb0555 – volume: 6 start-page: 354 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1440 article-title: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src publication-title: Signal Transduct. Target. Ther. doi: 10.1038/s41392-021-00765-3 – volume: 248 start-page: 953 year: 1987 ident: 10.1016/j.exger.2024.112389_bb0130 article-title: Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans publication-title: Biochem. J. doi: 10.1042/bj2480953 – volume: 3 start-page: 119 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1370 article-title: Nephro-protective significance of kaempferol on mercuric chloride induced toxicity in Wistar albino rats publication-title: Biomedicine & Aging Pathology. doi: 10.1016/j.biomag.2013.05.004 – volume: 54 start-page: 3738 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0165 article-title: Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-11612 – volume: 13 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0910 article-title: Plants’ bioactive secondary metabolites in the management of sepsis: recent findings on their mechanism of action publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.1046523 – volume: 1059 start-page: 14 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0560 article-title: Comparative pharmacokinetic study of baicalin and its metabolites after oral administration of baicalin and Chaiqin Qingning capsule in normal and febrile rats publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2017.05.018 – volume: 36 start-page: S123 issue: Suppl. 1 year: 1984 ident: 10.1016/j.exger.2024.112389_bb1045 article-title: Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences publication-title: Calcif. Tissue Int. doi: 10.1007/BF02406145 – volume: 14 start-page: 5576 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1430 article-title: Kaempferol targets estrogen-related receptor α and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions publication-title: Exp. Ther. Med. – volume: 11 start-page: 433 year: 1976 ident: 10.1016/j.exger.2024.112389_bb0515 article-title: Flavonols and flavones in food plants: a review publication-title: Int. J. Food Sci. Technol. doi: 10.1111/j.1365-2621.1976.tb00743.x – volume: 11 start-page: 36 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0905 article-title: Anti-psychotic activity of aqueous root extract of Hemidesmus indicus: a time bound study in rats publication-title: Recent Pat. Drug Deliv. Formul. – volume: 251 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0595 article-title: The complex role of MEG3: an emerging long non-coding RNA in breast cancer publication-title: Pathol. Res. Pract. doi: 10.1016/j.prp.2023.154850 – volume: 49 start-page: 1603 year: 2010 ident: 10.1016/j.exger.2024.112389_bb1120 article-title: Oxidative stress, inflammation, and cancer: how are they linked? publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2010.09.006 – volume: 72 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0815 article-title: Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat publication-title: J. Funct. Foods doi: 10.1016/j.jff.2020.104041 – volume: 11 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0950 article-title: Phytochemical composition of different botanical parts of Morus species, health benefits and application in food industry publication-title: Plants (Basel, Switzerland) – volume: 25 start-page: 974 year: 1994 ident: 10.1016/j.exger.2024.112389_bb1265 article-title: Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells publication-title: J. Neurobiol. doi: 10.1002/neu.480250807 – volume: 17 start-page: 421 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0095 article-title: Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer's disease publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/1871527317666180508123050 – volume: 70 start-page: 1098 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0955 article-title: Unique human and mouse β-cell senescence-associated secretory phenotype (SASP) reveal conserved signaling pathways and heterogeneous factors publication-title: Diabetes doi: 10.2337/db20-0553 – volume: 16 start-page: 733 year: 2015 ident: 10.1016/j.exger.2024.112389_bb1145 article-title: Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway publication-title: Biogerontology doi: 10.1007/s10522-015-9596-6 – volume: 14 start-page: 56 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1465 article-title: Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging publication-title: Food Funct. doi: 10.1039/D2FO02688K – volume: 47 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1520 article-title: Advanced oxidation protein products aggravate age-related bone loss by increasing sclerostin expression in osteocytes via ROS-dependent downregulation of Sirt1 publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2021.4941 – volume: 83 start-page: 837 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0340 article-title: Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress publication-title: Planta Med. doi: 10.1055/s-0043-103415 – volume: 17 start-page: 549 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1195 article-title: Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.03.009 – volume: 15 start-page: 167 year: 2009 ident: 10.1016/j.exger.2024.112389_bb1345 article-title: Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats publication-title: Nat. Prod. Sci. – year: 2018 ident: 10.1016/j.exger.2024.112389_bb0420 – volume: 19 start-page: 651 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0645 article-title: Comparative pharmacokinetic study of five flavonoids in normal rats and rats with gastric ulcer following oral administration of Mongolian medicine, Shudage-4 by UPLC–ESI–MS/MS publication-title: Trop. J. Pharm. Res. doi: 10.4314/tjpr.v19i3.28 – volume: 12 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0105 article-title: Targeting mitochondrial calcium uptake with the natural flavonol kaempferol, to promote metabolism/secretion coupling in pancreatic β-cells publication-title: Nutrients doi: 10.3390/nu12020538 – volume: 8 start-page: 628 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0065 article-title: The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks publication-title: Aging Dis. doi: 10.14336/AD.2017.0103 – volume: 102 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1555 article-title: Understanding the molecular mechanism of Ginkgo Folium-Forsythiae Fructus for cerebral atherosclerosis treatment using network pharmacology and molecular docking publication-title: Medicine – volume: 47 start-page: 2196 year: 2009 ident: 10.1016/j.exger.2024.112389_bb1360 article-title: In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves publication-title: Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. doi: 10.1016/j.fct.2009.06.005 – volume: 40 start-page: 2379 year: 1992 ident: 10.1016/j.exger.2024.112389_bb0520 article-title: Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands publication-title: J. Agric. Food Chem. doi: 10.1021/jf00024a011 – volume: 531 start-page: 508 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1140 article-title: Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease publication-title: Nature doi: 10.1038/nature17172 – volume: 50 start-page: 246 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0800 article-title: Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO publication-title: Acta Biochim. Biophys. Sin. doi: 10.1093/abbs/gmy002 – volume: 8 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1275 article-title: The mitochondrial basis of aging and age-related disorders publication-title: Genes doi: 10.3390/genes8120398 – volume: 20 start-page: 728 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0805 article-title: Synergistic effect of kaempferol and 5-fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway publication-title: Mol. Med. Rep. – volume: 189 start-page: 186 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1290 article-title: Ethnobotanical uses of neem (Azadirachta indica A. Juss.; Meliaceae) leaves in Bali (Indonesia) and the Indian subcontinent in relation with historical background and phytochemical properties publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.05.014 – volume: 40 start-page: 2408 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0280 article-title: Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.120.314333 – volume: 54 start-page: 818 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0255 article-title: Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis publication-title: Arthritis Rheum. doi: 10.1002/art.21639 – volume: 31 start-page: 1920 year: 2016 ident: 10.1016/j.exger.2024.112389_bb0330 article-title: Identification of senescent cells in the bone microenvironment publication-title: J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. doi: 10.1002/jbmr.2892 – volume: 72 start-page: 40 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0575 article-title: The burden of cardiovascular diseases due to COVID-19 pandemic publication-title: Thorac. Cardiovasc. – volume: 18 start-page: 32 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0770 article-title: Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration publication-title: J. Neuroinflammation doi: 10.1186/s12974-021-02088-0 – volume: 111 start-page: 245 year: 2012 ident: 10.1016/j.exger.2024.112389_bb1385 article-title: Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.111.261388 – volume: 1863 start-page: 2307 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1425 article-title: Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: therapeutical effects of kaempferol publication-title: Biochimica et Biophysica Acta Molecular Basis of Disease doi: 10.1016/j.bbadis.2017.06.011 – volume: 80 start-page: 15 year: 2004 ident: 10.1016/j.exger.2024.112389_bb0735 article-title: How should we assess the effects of exposure to dietary polyphenols in vitro? publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/80.1.15 – volume: 36 start-page: 1199 year: 2002 ident: 10.1016/j.exger.2024.112389_bb0970 article-title: Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity publication-title: Free Radic. Res. doi: 10.1080/1071576021000016463 – volume: 233 start-page: 284 year: 2019 ident: 10.1016/j.exger.2024.112389_bb1025 article-title: Wound healing effect of kaempferol in diabetic and nondiabetic rats publication-title: J. Surg. Res. doi: 10.1016/j.jss.2018.08.009 – volume: 10 start-page: 1306 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0610 article-title: Loss of NAMPT in aging retinal pigment epithelium reduces NAD(+) availability and promotes cellular senescence publication-title: Aging doi: 10.18632/aging.101469 – volume: 173 start-page: 71 year: 2000 ident: 10.1016/j.exger.2024.112389_bb1190 article-title: Anaerobic degradation of flavonoids by Eubacterium ramulus publication-title: Arch. Microbiol. doi: 10.1007/s002030050010 – volume: 9 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0170 article-title: Potential protective role exerted by secoiridoids from Olea europaea L. in cancer, cardiovascular, neurodegenerative, aging-related, and immunoinflammatory diseases publication-title: Antioxidants (Basel, Switzerland) – volume: 121 start-page: 369 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1560 article-title: mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice publication-title: J. Clin. Invest. doi: 10.1172/JCI44303 – volume: 20 start-page: 198 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0045 article-title: Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats publication-title: Redox Report: Communications in Free Radical Research. doi: 10.1179/1351000214Y.0000000117 – volume: 12 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0070 article-title: Beyond diabetes management: unraveling metformin's long-term effects on vitamin B12 publication-title: Clin. Diabetol. doi: 10.5603/cd.97473 – volume: 7 start-page: 33 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0715 article-title: Alzheimer disease publication-title: Nat. Rev. Dis. Primers doi: 10.1038/s41572-021-00269-y – volume: 8 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0965 article-title: Memorable food: fighting age-related neurodegeneration by precision nutrition publication-title: Front. Nutr. doi: 10.3389/fnut.2021.688086 – volume: 55 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0685 article-title: From pre-diabetes to diabetes: diagnosis, treatments and translational research publication-title: Medicina (Kaunas, Lithuania) – volume: 16 start-page: 144 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0865 article-title: A new view of carcinogenesis and an alternative approach to cancer therapy publication-title: Molecular Medicine (Cambridge, Mass). doi: 10.2119/molmed.2009.00162 – volume: 16 start-page: 270 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0465 article-title: Association of LAG3 genetic variation with an increased risk of PD in Chinese female population publication-title: J. Neuroinflammation doi: 10.1186/s12974-019-1654-6 – volume: 69 start-page: 681 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0570 article-title: A review of the Phyllanthus genus plants: their phytochemistry, traditional uses, and potential inhibition of xanthine oxidase publication-title: Pharmacia doi: 10.3897/pharmacia.69.e87013 – volume: 1722 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0810 article-title: Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats publication-title: Brain Res. doi: 10.1016/j.brainres.2019.146361 – volume: 9 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0525 article-title: Pharmacological targets of kaempferol within inflammatory pathways-a hint towards the central role of tryptophan metabolism publication-title: Antioxidants (Basel, Switzerland) – volume: 12 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0690 article-title: The intersection of obesity and skeletal health: insights from post-COVID-19 Indian population publication-title: Clinical Diabetology. doi: 10.5603/cd.97294 – volume: 79 start-page: 1565 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0385 article-title: Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology publication-title: Planta Med. doi: 10.1055/s-0033-1350808 – volume: 409 start-page: 12 year: 1997 ident: 10.1016/j.exger.2024.112389_bb0915 article-title: Bioavailability of rutin and quercetin in rats publication-title: FEBS Lett. doi: 10.1016/S0014-5793(97)00467-5 – volume: 27 start-page: 6164 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1105 article-title: Andrographis paniculata dosage forms and advances in nanoparticulate delivery systems: an overview publication-title: Molecules (Basel, Switzerland) doi: 10.3390/molecules27196164 – volume: 25 start-page: 408 year: 2008 ident: 10.1016/j.exger.2024.112389_bb0325 article-title: Treatment options in Alzheimer’s disease: maximizing benefit, managing expectations publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000122962 – volume: 81 start-page: 1045 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0185 article-title: Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats publication-title: Fitoterapia doi: 10.1016/j.fitote.2010.06.028 – volume: 41 start-page: 1198 year: 2016 ident: 10.1016/j.exger.2024.112389_bb0795 article-title: Biopharmaceutics classification and absorption mechanisms primary study on four kinds of flavonoids publication-title: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China J. Chin. Mater. Med. – volume: 171 start-page: 345 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1405 article-title: Redox signaling in heart failure and therapeutic implications publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2021.05.013 – volume: 776 start-page: 31 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0765 article-title: The impact of base excision DNA repair in age-related neurodegenerative diseases publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2014.12.011 – volume: 103 start-page: 1860 year: 1978 ident: 10.1016/j.exger.2024.112389_bb0925 article-title: Phytoestrogen interaction with estrogen receptors in human breast cancer cells publication-title: Endocrinology doi: 10.1210/endo-103-5-1860 – volume: 63 start-page: 1035 year: 2000 ident: 10.1016/j.exger.2024.112389_bb1070 article-title: Flavonoids as antioxidants publication-title: J. Nat. Prod. doi: 10.1021/np9904509 – volume: 445 start-page: 656 year: 2007 ident: 10.1016/j.exger.2024.112389_bb1470 article-title: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas publication-title: Nature doi: 10.1038/nature05529 – volume: 37 start-page: 199 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0300 article-title: Herbal medicines in neurodegenerative disorders: an evolutionary approach through novel drug delivery system publication-title: Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer. doi: 10.1615/JEnvironPatholToxicolOncol.2018027246 – volume: 58 start-page: 947 year: 2004 ident: 10.1016/j.exger.2024.112389_bb0305 article-title: Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans publication-title: Eur. J. Clin. Nutr. doi: 10.1038/sj.ejcn.1601916 – volume: 2018 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0295 article-title: Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2018/1610751 – volume: 25 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1085 article-title: Mechanisms of aging and the preventive effects of resveratrol on age-related diseases publication-title: Molecules (Basel, Switzerland) doi: 10.3390/molecules25204649 – volume: 10 start-page: 1953 year: 1989 ident: 10.1016/j.exger.2024.112389_bb0380 article-title: Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine publication-title: Carcinogenesis doi: 10.1093/carcin/10.10.1953 – volume: 21 start-page: 396 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1395 article-title: Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling publication-title: BMC Cancer doi: 10.1186/s12885-021-08158-z – volume: 2022 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1090 article-title: Orientin prolongs the longevity of Caenorhabditis elegans and postpones the development of neurodegenerative diseases via nutrition sensing and cellular protective pathways publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2022/8878923 – volume: 46 start-page: 329 year: 2007 ident: 10.1016/j.exger.2024.112389_bb0780 article-title: Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds publication-title: Eur. J. Nutr. doi: 10.1007/s00394-007-0670-y – volume: 2013 year: 2013 ident: 10.1016/j.exger.2024.112389_bb1375 article-title: Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2013/485201 – volume: 284 start-page: G980 year: 2003 ident: 10.1016/j.exger.2024.112389_bb0245 article-title: The splanchnic metabolism of flavonoids highly differed according to the nature of the compound publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00223.2002 – volume: 8 start-page: 373 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1280 article-title: De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2014.00373 – volume: 11 start-page: 280 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1315 article-title: Cardiomyocyte senescence and cellular communications within myocardial microenvironments publication-title: Front. Endocrinol. doi: 10.3389/fendo.2020.00280 – volume: 12 start-page: 383 year: 1997 ident: 10.1016/j.exger.2024.112389_bb1255 article-title: Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol publication-title: Mutagenesis doi: 10.1093/mutage/12.5.383 – volume: 11 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0250 article-title: Dietary quercetin and kaempferol: bioavailability and potential cardiovascular-related bioactivity in humans publication-title: Nutrients doi: 10.3390/nu11102288 – volume: 63 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1175 article-title: Neurodegeneration in accelerated aging publication-title: Dan. Med. J. – volume: 46 start-page: 622 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1580 article-title: Advances in the structure-activity relationship study of natural flavonoids and its derivatives publication-title: Yao Xue Xue Bao = Acta Pharm. Sin. – volume: 11 start-page: 298 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0155 article-title: A review on the dietary flavonoid kaempferol publication-title: Mini-Rev. Med. Chem. doi: 10.2174/138955711795305335 – volume: 28 start-page: 1214 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0195 article-title: DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism publication-title: Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research. doi: 10.1002/jbmr.1851 – volume: 9 start-page: 303 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1295 article-title: The role of microparticles in chronic obstructive pulmonary disease publication-title: Int. J. Chron. Obstruct. Pulmon. Dis. – volume: 4 start-page: 331 year: 2005 ident: 10.1016/j.exger.2024.112389_bb1420 article-title: Osteoarthritis - an untreatable disease? publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd1693 – volume: 129 start-page: 1203 year: 2019 ident: 10.1016/j.exger.2024.112389_bb1515 article-title: Intracerebroventricular microinjection of kaempferol on memory retention of passive avoidance learning in rats: involvement of cholinergic mechanism(s) publication-title: Int. J. Neurosci. doi: 10.1080/00207454.2019.1653867 – volume: 23 start-page: 1072 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0335 article-title: Targeting cellular senescence prevents age-related bone loss in mice publication-title: Nat. Med. doi: 10.1038/nm.4385 – volume: 21 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0650 article-title: Regulation and roles of RNA modifications in aging-related diseases publication-title: Aging Cell doi: 10.1111/acel.13657 – volume: 22 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0935 article-title: Selective cardiomyocyte oxidative stress leads to bystander senescence of cardiac stromal cells publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22052245 – volume: 2015 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0705 article-title: The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets publication-title: Mediat. Inflamm. doi: 10.1155/2015/904142 – volume: 14 start-page: 209 year: 2012 ident: 10.1016/j.exger.2024.112389_bb0190 article-title: Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2012.07.007 – volume: 22 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0730 article-title: Mitochondrial oxidative stress-a causative factor and therapeutic target in many diseases publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms222413384 – volume: 42 start-page: 1 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1130 article-title: Exploring the mechanical perspective of a new anti-tumor agent: melatonin publication-title: Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer. doi: 10.1615/JEnvironPatholToxicolOncol.2022042088 – volume: 49 start-page: 11101 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0035 article-title: Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-022-07863-7 – volume: 9 start-page: 62 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0290 article-title: Age-related macular degeneration: epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy publication-title: Genes & Diseases. doi: 10.1016/j.gendis.2021.02.009 – volume: 21 start-page: 323 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0850 article-title: Role of aqueous extract of the wood ear mushroom, Auricularia polytricha (Agaricomycetes), in avoidance of haloperidol-lnduced catalepsy via oxidative stress in rats publication-title: Int J Med Mushrooms. doi: 10.1615/IntJMedMushrooms.2019030351 – volume: 234 start-page: 295 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1180 article-title: Endothelial microparticles as conveyors of information in atherosclerotic disease publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2014.03.019 – volume: 7 start-page: 861 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1270 article-title: Bioefficacy of Graviola leaf extracts in scavenging free radicals and upregulating antioxidant genes publication-title: Food Funct. doi: 10.1039/C5FO01258A – volume: 18 start-page: 675 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0475 article-title: Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19 publication-title: Regen. Med. doi: 10.2217/rme-2023-0077 – volume: 63 start-page: 2773 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1490 article-title: Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2021.1980762 – volume: 128 start-page: 474 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0455 article-title: SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.120.318353 – volume: 2022 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1150 article-title: Protective effect of kaempferol and its nanoparticles on 5-fluorouracil-induced cardiotoxicity in rats publication-title: Biomed. Res. Int. doi: 10.1155/2022/2273000 – volume: 5 start-page: 1395 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1485 article-title: Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells publication-title: Food Funct. doi: 10.1039/c4fo00068d – volume: 169 start-page: 787 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0285 article-title: Association between long telomere length and insulin sensitization in adolescent girls with hyperinsulinemic androgen excess publication-title: JAMA Pediatr. doi: 10.1001/jamapediatrics.2015.0439 – volume: 141 start-page: 810 year: 2012 ident: 10.1016/j.exger.2024.112389_bb0470 article-title: Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.03.013 – volume: 29 start-page: 63369 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0600 article-title: Ruthana date extract inhibited proliferation of human hepatocellular carcinoma (HepG2) cells by modulation of BAX gene publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-022-20240-y – volume: 19 start-page: 627 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0695 article-title: Recent studies on kaempferol and its biological and pharmacological activities publication-title: EXCLI J. – volume: 17 start-page: 1156 year: 2014 ident: 10.1016/j.exger.2024.112389_bb0270 article-title: Alzheimer’s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci publication-title: Nat. Neurosci. doi: 10.1038/nn.3786 – volume: 33 start-page: 1065 year: 2019 ident: 10.1016/j.exger.2024.112389_bb1475 article-title: Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway publication-title: Phytotherapy Research: PTR. doi: 10.1002/ptr.6300 – volume: 2022 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1320 article-title: Research on the mechanism of Kaempferol for treating senile osteoporosis by network pharmacology and molecular docking publication-title: Evidence-based Complementary and Alternative Medicine: eCAM. doi: 10.1155/2022/6741995 – volume: 7 year: 2012 ident: 10.1016/j.exger.2024.112389_bb0395 article-title: Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation publication-title: PLoS One doi: 10.1371/journal.pone.0032673 – volume: 6 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0460 article-title: Short telomeres compromise β-cell signaling and survival publication-title: PLoS One – volume: 134 start-page: 367 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0505 article-title: The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2013.07.002 – volume: 31 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1340 article-title: Endothelial mitochondria regulate local calcium signalling in mesenteric arteries from mice publication-title: FASEB J. doi: 10.1096/fasebj.31.1_supplement.681.7 – volume: 89 start-page: 4668 year: 1992 ident: 10.1016/j.exger.2024.112389_bb1335 article-title: Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.89.10.4668 – volume: 128 start-page: 492 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0205 article-title: Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.120.317348 – volume: 320 start-page: C465 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0025 article-title: Molecular nature and physiological role of the mitochondrial calcium uniporter channel publication-title: Am. J. Phys. Cell Phys. – volume: 20 start-page: 4813 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0975 article-title: In vitro neuroprotective activities of compounds from Angelica shikokiana Makino publication-title: Molecules (Basel, Switzerland). doi: 10.3390/molecules20034813 – volume: 22 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1100 article-title: Kaempferol inhibits zearalenone-induced oxidative stress and apoptosis via the PI3K/Akt-mediated Nrf2 signaling pathway: in vitro and in vivo studies publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22010217 – volume: 103 start-page: 110 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0345 article-title: Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: an in vitro evaluation with focus on antiepileptic drugs publication-title: Food Research International (Ottawa, Ont). doi: 10.1016/j.foodres.2017.10.010 – volume: 78 start-page: 140 year: 2005 ident: 10.1016/j.exger.2024.112389_bb1455 article-title: Absorption and enterohepatic circulation of baicalin in rats publication-title: Life Sci. doi: 10.1016/j.lfs.2005.04.072 – volume: 60 start-page: 83 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0200 article-title: Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress publication-title: Endocrine doi: 10.1007/s12020-018-1525-4 – volume: 371 start-page: 265 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0655 article-title: Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders publication-title: Science (New York, N.Y.) doi: 10.1126/science.abb5916 – volume: 19 start-page: 529 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1260 article-title: Phytochemistry and pharmacological profile of drumstick tree “Moringa oleifera lam”: an overview publication-title: Curr. Nutr. Food Sci. doi: 10.2174/1573401319666221226144613 – volume: 24 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0040 article-title: Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms24108630 – volume: 11 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0275 article-title: Maternal flavonoids intake reverts depression-like behaviour in rat female offspring publication-title: Nutrients doi: 10.3390/nu11030572 – volume: 578 start-page: 273 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1215 article-title: Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy publication-title: Nature doi: 10.1038/s41586-020-1984-7 – volume: 15 start-page: 3425 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1550 article-title: Network pharmacology and experimental evidence: PI3K/AKT signaling pathway is involved in the antidepressive roles of Chaihu Shugan San publication-title: Drug Des. Devel. Ther. doi: 10.2147/DDDT.S315060 – volume: 177 start-page: 91 year: 2002 ident: 10.1016/j.exger.2024.112389_bb0390 article-title: Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics publication-title: Toxicology doi: 10.1016/S0300-483X(02)00198-1 – volume: 21 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1125 article-title: The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21072358 – volume: 15 start-page: 8 year: 2018 ident: 10.1016/j.exger.2024.112389_bb1350 article-title: Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms publication-title: Immun. Ageing doi: 10.1186/s12979-017-0108-1 – volume: 106 start-page: 175 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0310 article-title: Chemically characterized Mentha cardiaca L. essential oil as plant based preservative in view of efficacy against biodeteriorating fungi of dry fruits, aflatoxin secretion, lipid peroxidation and safety profile assessment publication-title: Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. doi: 10.1016/j.fct.2017.05.043 – volume: 24 start-page: 304 year: 2016 ident: 10.1016/j.exger.2024.112389_bb0495 article-title: Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2015.12.021 – volume: 65 start-page: 615 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0410 article-title: Pathophysiology of age-related macular degeneration: implications for treatment publication-title: Ophthalmic Res. doi: 10.1159/000524942 – volume: 369 start-page: 489 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0565 article-title: Monetary costs of dementia in the United States publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc1305541 – volume: 50 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1460 article-title: Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment publication-title: Brazilian Journal of Medical and Biological Research = Revista brasileira de pesquisas medicas e biologicas. – volume: 15 start-page: 1779 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0830 article-title: Integrating network pharmacology and experimental validation to decipher the mechanism of action of Huanglian Jiedu decoction in treating atherosclerosis publication-title: Drug Des. Devel. Ther. doi: 10.2147/DDDT.S304911 – year: 2023 ident: 10.1016/j.exger.2024.112389_bb0400 article-title: Exploring the therapeutic potential of naturally occurring piceatannol in non-communicable diseases publication-title: BioFactors (Oxford, England) doi: 10.1002/biof.2009 – volume: 11 start-page: 5427 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0015 article-title: A randomized, placebo-controlled trial evaluating the safety of excessive administration of kaempferol aglycone publication-title: Food Sci. Nutr. doi: 10.1002/fsn3.3499 – volume: 104 start-page: 193 year: 1996 ident: 10.1016/j.exger.2024.112389_bb1155 article-title: Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei publication-title: Cancer Lett. doi: 10.1016/0304-3835(96)04251-6 – volume: 13 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1240 article-title: Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: network pharmacology and experimental validation publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.967164 – volume: 384 start-page: 19 year: 2004 ident: 10.1016/j.exger.2024.112389_bb0980 article-title: Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids publication-title: Biochem. J. doi: 10.1042/BJ20040990 – volume: 22 start-page: 1159 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0895 article-title: Kaempferitrin prevents bone lost in ovariectomized rats publication-title: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. doi: 10.1016/j.phymed.2015.09.003 – volume: 15 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1415 article-title: Natural phytochemicals as SIRT activators-focus on potential biochemical mechanisms publication-title: Nutrients doi: 10.3390/nu15163578 – volume: 66 start-page: 246 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0085 article-title: Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2013-2015 publication-title: MMWR Morb. Mortal Wkly. Rep. doi: 10.15585/mmwr.mm6609e1 – volume: 33 start-page: 823 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0100 article-title: Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders publication-title: Aging Clin. Exp. Res. doi: 10.1007/s40520-019-01359-4 – volume: 12 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0740 article-title: Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells publication-title: Cells doi: 10.3390/cells12121568 – volume: 101 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0825 article-title: Potential active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking publication-title: Medicine – volume: 19 start-page: 619 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1185 article-title: Senescence and cancer - role and therapeutic opportunities publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/s41571-022-00668-4 – volume: 11 start-page: 1177 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0995 article-title: Nutraceutical effects of Emblicaofficinalis in age-related macular degeneration publication-title: Aging doi: 10.18632/aging.101820 – volume: 670 start-page: 325 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1525 article-title: Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2011.08.011 – volume: 58 start-page: 261 year: 2007 ident: 10.1016/j.exger.2024.112389_bb0135 article-title: Urinary excretion of kaempferol from common beans (Phaseolus vulgaris L.) in humans publication-title: Int. J. Food Sci. Nutr. doi: 10.1080/09637480601154228 – volume: 557 start-page: 221 year: 2007 ident: 10.1016/j.exger.2024.112389_bb0415 article-title: The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang liver cells publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2006.11.014 – volume: 30 start-page: 356 year: 2009 ident: 10.1016/j.exger.2024.112389_bb0090 article-title: Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats publication-title: Biopharm. Drug Dispos. doi: 10.1002/bdd.677 – volume: 6 start-page: 612 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1325 article-title: BRD4 connects enhancer remodeling to senescence immune surveillance publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-16-0217 – volume: 2013 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0535 article-title: Nrf2 and cardiovascular defense publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2013/104308 – volume: 34 start-page: 1291 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0785 article-title: Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson’s disease publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.34.1291 – volume: 91 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0430 article-title: Control by Ca(2+) of mitochondrial structure and function in pancreatic β-cells publication-title: Cell Calcium doi: 10.1016/j.ceca.2020.102282 – volume: 12 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1450 article-title: Kaempferol ameliorates the inhibitory activity of dexamethasone in the osteogenesis of MC3T3-E1 cells by JNK and p38-MAPK pathways publication-title: Front. Pharmacol. doi: 10.3389/fphar.2021.739326 – volume: 5 start-page: 55 year: 1983 ident: 10.1016/j.exger.2024.112389_bb1300 article-title: Carcinogenicity test of quercetin and kaempferol in rats by oral administration publication-title: J. Food Saf. doi: 10.1111/j.1745-4565.1983.tb00455.x – start-page: S96 year: 2004 ident: 10.1016/j.exger.2024.112389_bb0930 article-title: Chondrocyte senescence, joint loading and osteoarthritis publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/01.blo.0000143818.74887.b1 – volume: 25 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1210 article-title: P53 regulation of osteoblast differentiation is mediated through specific microRNAs publication-title: Biochemistry and Biophysics Reports. doi: 10.1016/j.bbrep.2021.100920 – volume: 101 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0140 article-title: Mechanism of Epimedium intervention in heart failure based on network pharmacology and molecular docking technology publication-title: Medicine doi: 10.1097/MD.0000000000032059 – volume: 37 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0590 article-title: From nature to therapy: luteolin’s potential as an immune system modulator in inflammatory disorders publication-title: J. Biochem. Mol. Toxicol. doi: 10.1002/jbt.23482 – volume: 17 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0060 article-title: Medicinal plants with antioxidant properties from Banat region (Romania): a rich pool for the discovery of multi-target phytochemicals active in free-radical related disorders publication-title: Analele Universitatii din Oradea-Fascicula Biologie. – volume: 39 start-page: 80 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1010 article-title: Kaempferol protects against retinal photoreceptor degeneration in a mouse model of light-induced retinal injury publication-title: Journal of Ocular Pharmacology and Therapeutics: The Official Journal of the Association for Ocular Pharmacology and Therapeutics. doi: 10.1089/jop.2022.0128 – volume: 28 start-page: 173 year: 2003 ident: 10.1016/j.exger.2024.112389_bb1390 article-title: Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets publication-title: Eur. J. Drug Metab. Pharmacokinet. doi: 10.1007/BF03190482 – volume: 112 start-page: e99 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0845 article-title: Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.111.300543 – volume: 50 start-page: 78 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0760 article-title: Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.200500144 – volume: 281 start-page: 37102 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0880 article-title: Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism publication-title: J. Biol. Chem. doi: 10.1074/jbc.M606804200 – volume: 15 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0225 article-title: Immunomodulation in age-related disorders and nanotechnology interventions publication-title: Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. doi: 10.1002/wnan.1840 – volume: 2019 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0370 article-title: Beneficial role of phytochemicals on oxidative stress and age-related diseases publication-title: Biomed. Res. Int. doi: 10.1155/2019/8748253 – volume: 7 start-page: 31 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1365 article-title: The role of inflammation in epilepsy publication-title: Nat. Rev. Neurol. doi: 10.1038/nrneurol.2010.178 – volume: 9 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1600 article-title: Targeting the mitochondria-proteostasis axis to delay aging publication-title: Frontiers in Cell and Developmental Biology. doi: 10.3389/fcell.2021.656201 – volume: 1865 start-page: 1802 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0640 article-title: Endothelial cell senescence in aging-related vascular dysfunction publication-title: Biochim. Biophys. Acta Mol. basis Dis. doi: 10.1016/j.bbadis.2018.08.008 – volume: 74 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1035 article-title: Antioxidant, anti-inflammatory and neuroprotective effect of kaempferol on rotenone-induced Parkinson’s disease model of rats and SH-S5Y5 cells by preventing loss of tyrosine hydroxylase publication-title: J. Funct. Foods doi: 10.1016/j.jff.2020.104140 – volume: 2 start-page: 11 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1330 article-title: Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo publication-title: Food Funct. doi: 10.1039/C0FO00106F – volume: 12 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0215 article-title: A critical review of kaempferol in intestinal health and diseases publication-title: Antioxidants (Basel, Switzerland) – volume: 13 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0440 article-title: Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing publication-title: Front. Oncol. doi: 10.3389/fonc.2023.1169168 – volume: 68 start-page: 476 year: 2016 ident: 10.1016/j.exger.2024.112389_bb0145 article-title: Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders publication-title: Pharmacol. Rev. doi: 10.1124/pr.115.010652 – volume: 8 start-page: 82 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1585 article-title: A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease publication-title: NPJ Parkinson's Disease. doi: 10.1038/s41531-022-00347-2 – volume: 99 start-page: 2771 year: 2014 ident: 10.1016/j.exger.2024.112389_bb1310 article-title: β-Cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2014-1222 – volume: 9 start-page: 1798 year: 2018 ident: 10.1016/j.exger.2024.112389_bb1015 article-title: Exercise, telomeres, and cancer: “the exercise-telomere hypothesis” publication-title: Front. Physiol. doi: 10.3389/fphys.2018.01798 – volume: 108 start-page: 741 year: 2012 ident: 10.1016/j.exger.2024.112389_bb1080 article-title: Pharmacoresistance publication-title: Handb. Clin. Neurol. doi: 10.1016/B978-0-444-52899-5.00025-3 – volume: 62 start-page: 1835 year: 2019 ident: 10.1016/j.exger.2024.112389_bb1030 article-title: Cellular senescence: at the nexus between ageing and diabetes publication-title: Diabetologia doi: 10.1007/s00125-019-4934-x – volume: 118 start-page: 3272 year: 2023 ident: 10.1016/j.exger.2024.112389_bb1170 article-title: Global burden of heart failure: a comprehensive and updated review of epidemiology publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvac013 – volume: 57 start-page: 5910 year: 2016 ident: 10.1016/j.exger.2024.112389_bb0150 article-title: Senescence increases choroidal endothelial stiffness and susceptibility to complement injury: implications for Choriocapillaris loss in AMD publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-19727 – volume: 32 start-page: 197 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0700 article-title: Kaempferol modulates pro-inflammatory NF-kappaB activation by suppressing advanced glycation endproducts-induced NADPH oxidase publication-title: Age (Dordr.) doi: 10.1007/s11357-009-9124-1 – volume: 877 start-page: 3595 year: 2009 ident: 10.1016/j.exger.2024.112389_bb1530 article-title: Sensitive determination of kaempferol in rat plasma by high-performance liquid chromatography with chemiluminescence detection and application to a pharmacokinetic study publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2009.08.046 – volume: 61 start-page: 11033 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0110 article-title: Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans publication-title: J. Agric. Food Chem. doi: 10.1021/jf402838a – volume: 82 start-page: 615 year: 2008 ident: 10.1016/j.exger.2024.112389_bb0320 article-title: Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity publication-title: Life Sci. doi: 10.1016/j.lfs.2007.12.021 – volume: 10 start-page: 7706 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1480 article-title: Molecular mechanism of Wutou Decoction in the treatment of osteoarthritis: a bioinformatics and molecular docking study publication-title: Annals of Palliative Medicine. doi: 10.21037/apm-21-1691 – volume: 21 start-page: 104 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1055 article-title: Pharmacological activities and therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: a review of medicinal importance and health benefits publication-title: Cardiovasc. Hematol. Disord. Drug Targets doi: 10.2174/1871529X21666210812111931 – volume: 81 start-page: 849 year: 2007 ident: 10.1016/j.exger.2024.112389_bb0675 article-title: Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans publication-title: Arch. Toxicol. doi: 10.1007/s00204-007-0215-4 – volume: 19 start-page: 313 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0620 article-title: Identification of kaempferol as viral entry inhibitor and DL-arginine as viral replication inhibitor from selected plants of Indian traditional medicine against COVID-19: an in silico guided in vitro approach publication-title: Curr. Comput. Aided Drug Des. doi: 10.2174/1573409919666230112123213 – volume: 32 start-page: 133 year: 2009 ident: 10.1016/j.exger.2024.112389_bb0790 article-title: Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats publication-title: Arch. Pharm. Res. doi: 10.1007/s12272-009-1127-z – volume: 3 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0835 article-title: Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration publication-title: JCI Insight doi: 10.1172/jci.insight.120157 – volume: 10 start-page: 256 year: 2009 ident: 10.1016/j.exger.2024.112389_bb1355 article-title: Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways publication-title: Curr. Drug Metab. doi: 10.2174/138920009787846369 – volume: 8 start-page: 2189 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0010 article-title: Kaempferol mitigates endoplasmic reticulum stress induced cell death by targeting caspase 3/7 publication-title: Sci. Rep. doi: 10.1038/s41598-018-20499-7 – volume: 54 start-page: 297 year: 1978 ident: 10.1016/j.exger.2024.112389_bb0900 article-title: Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium publication-title: Mutat. Res. doi: 10.1016/0165-1161(78)90020-1 – volume: 2013 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0445 article-title: Blockade of airway inflammation by kaempferol via disturbing Tyk-STAT signaling in airway epithelial cells and in asthmatic mice publication-title: Evidence-based Complementary and Alternative Medicine: eCAM. doi: 10.1155/2013/250725 – volume: 214 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1200 article-title: Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2022.102270 – volume: 191 start-page: 432 year: 2021 ident: 10.1016/j.exger.2024.112389_bb1220 article-title: Current update on psyllium and alginate incorporate for interpenetrating polymer network (IPN) and their biomedical applications publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2021.09.115 – volume: 22 start-page: 2474 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1205 article-title: Anticancer properties of kaempferol on cellular signaling pathways publication-title: Curr. Top. Med. Chem. doi: 10.2174/1568026622666220907112822 – volume: 23 start-page: 3925 year: 2017 ident: 10.1016/j.exger.2024.112389_bb1595 article-title: Kaempferol alleviates the interleukin-1β-induced inflammation in rat osteoarthritis chondrocytes via suppression of NF-κB publication-title: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. doi: 10.12659/MSM.902491 – volume: 23 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0605 article-title: Investigation of the molecular mechanisms underlying the antiatherogenic actions of kaempferol in human THP-1 macrophages publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms23137461 – volume: 49 start-page: 3106 year: 2001 ident: 10.1016/j.exger.2024.112389_bb0960 article-title: Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants publication-title: J. Agric. Food Chem. doi: 10.1021/jf000892m – volume: 38 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0055 article-title: Length-independent telomere damage drives post-mitotic cardiomyocyte senescence publication-title: EMBO J. doi: 10.15252/embj.2018100492 – volume: 164 start-page: 1008 year: 2011 ident: 10.1016/j.exger.2024.112389_bb1050 article-title: Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01389.x – volume: 7 start-page: 23 year: 2008 ident: 10.1016/j.exger.2024.112389_bb1075 article-title: Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis publication-title: Aging Cell doi: 10.1111/j.1474-9726.2007.00350.x – volume: 60 start-page: S107 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0350 article-title: The DNA damage response in neurons: die by apoptosis or survive in a senescence-like state? publication-title: Journal of Alzheimer’s disease : JAD. doi: 10.3233/JAD-161221 – volume: 58 start-page: 620 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0775 article-title: Flavonol glycosides of sea buckthorn (Hippophaë rhamnoides ssp. sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion publication-title: J. Agric. Food Chem. doi: 10.1021/jf9029942 – volume: 58 start-page: 140 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0260 article-title: Multidrug resistance-associated proteins: expression and function in the central nervous system publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.2.3 – volume: 56 start-page: 29 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0220 article-title: Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2018.01.002 – volume: 23 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1065 article-title: Kaempferol: antimicrobial properties, sources, clinical, and traditional applications publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms232315054 – volume: 12 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0080 article-title: Chronic calcific pancreatitis presented with secondary diabetes and diabetic ketoacidosis: a case report publication-title: Clin. Diabetol. doi: 10.5603/DK.a2023.0015 – volume: 22 start-page: 266 year: 2011 ident: 10.1016/j.exger.2024.112389_bb0360 article-title: Endoplasmic reticulum stress and pancreatic β-cell death publication-title: Trends Endocrinol. Metab. – volume: 26 start-page: 1823 year: 2012 ident: 10.1016/j.exger.2024.112389_bb1305 article-title: Protective effect and potential mechanism of Ginkgo biloba extract EGb 761 on STZ-induced neuropathic pain in rats publication-title: Phytotherapy Research: PTR. doi: 10.1002/ptr.4648 – volume: 7 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0115 article-title: Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations publication-title: Transl. Psychiatry doi: 10.1038/tp.2017.165 – volume: 128 start-page: 1229 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0630 article-title: Senescent cells and osteoarthritis: a painful connection publication-title: J. Clin. Invest. doi: 10.1172/JCI95147 – volume: 13 start-page: 1827 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0725 article-title: Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.238714 – volume: 27 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1005 article-title: Flavonoids from Lycium barbarum leaves exhibit anti-aging effects through the redox-modulation publication-title: Molecules (Basel, Switzerland) doi: 10.3390/molecules27154952 – volume: 11 start-page: 224 year: 2009 ident: 10.1016/j.exger.2024.112389_bb0435 article-title: Cartilage homeostasis in health and rheumatic diseases publication-title: Arthritis Res. Ther. doi: 10.1186/ar2592 – volume: 26 start-page: 1120 year: 2003 ident: 10.1016/j.exger.2024.112389_bb1495 article-title: Glucurono- and sulfo-conjugation of kaempferol in rat liver subcellular preparations and cultured hepatocytes publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.26.1120 – volume: 161 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1540 article-title: The endoplasmic reticulum and calcium homeostasis in pancreatic beta cells publication-title: Endocrinology doi: 10.1210/endocr/bqz028 – volume: 36 start-page: 829 year: 2004 ident: 10.1016/j.exger.2024.112389_bb1380 article-title: Absorption and metabolism of flavonoids publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2004.01.002 – volume: 54 start-page: 9254 year: 2006 ident: 10.1016/j.exger.2024.112389_bb0540 article-title: Kaempferol in red and pinto bean seed (Phaseolus vulgaris L.) coats inhibits iron bioavailability using an in vitro digestion/human Caco-2 cell model publication-title: J. Agric. Food Chem. doi: 10.1021/jf0612981 – volume: 57 start-page: 399 year: 1999 ident: 10.1016/j.exger.2024.112389_bb1135 article-title: Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity publication-title: J. Neurosci. Res. doi: 10.1002/(SICI)1097-4547(19990801)57:3<399::AID-JNR12>3.0.CO;2-W – volume: 11 start-page: 595 year: 2010 ident: 10.1016/j.exger.2024.112389_bb0485 article-title: The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms11020595 – volume: 58 start-page: 14 year: 2014 ident: 10.1016/j.exger.2024.112389_bb0425 article-title: What is an anti-aging treatment? publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2014.07.003 – volume: 128 start-page: 44 year: 2017 ident: 10.1016/j.exger.2024.112389_bb0855 article-title: The role of aging in the development of osteoarthritis publication-title: Trans. Am. Clin. Climatol. Assoc. – volume: 41 start-page: 73 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0005 article-title: Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-019-0279-8 – volume: 15 start-page: 1860 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0490 article-title: Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease publication-title: Autophagy doi: 10.1080/15548627.2019.1596481 – volume: 23 year: 2018 ident: 10.1016/j.exger.2024.112389_bb1225 article-title: Antiulcer agents: from plant extracts to phytochemicals in healing promotion publication-title: Molecules (Basel, Switzerland) doi: 10.3390/molecules23071751 – volume: 12 start-page: 115 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0720 article-title: The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits publication-title: Lipids Health Dis. doi: 10.1186/1476-511X-12-115 – volume: 222 start-page: 393 year: 1989 ident: 10.1016/j.exger.2024.112389_bb0375 article-title: Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids publication-title: Mutat. Res. doi: 10.1016/0165-1218(89)90114-6 – volume: 66 start-page: 2201 year: 2014 ident: 10.1016/j.exger.2024.112389_bb0860 article-title: Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1 publication-title: Arthritis & Rheumatology (Hoboken, NJ). doi: 10.1002/art.38641 – volume: 249 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0580 article-title: Long non-coding RNAs in lung cancer: unraveling the molecular modulators of MAPK signaling publication-title: Pathol. Res. Pract. doi: 10.1016/j.prp.2023.154738 – volume: 366 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1510 article-title: Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2022.110135 – volume: 176 start-page: 19 year: 2018 ident: 10.1016/j.exger.2024.112389_bb0365 article-title: Caloric restriction and cellular senescence publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2018.10.005 – volume: 13 start-page: 89 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0075 article-title: Chronic calcific pancreatitis and its association with secondary diabetes mellitus publication-title: Journal of Endocrinology and Metabolism. doi: 10.14740/jem884 – volume: 249 year: 2023 ident: 10.1016/j.exger.2024.112389_bb0585 article-title: Probing the links: long non-coding RNAs and NF-κB signalling in atherosclerosis publication-title: Pathol. Res. Pract. doi: 10.1016/j.prp.2023.154773 – volume: 20 year: 2019 ident: 10.1016/j.exger.2024.112389_bb0615 article-title: Expression of longevity genes induced by a low-dose fluvastatin and valsartan combination with the potential to prevent/treat “aging-related disorders” publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20081844 – volume: 15 year: 2018 ident: 10.1016/j.exger.2024.112389_bb1590 article-title: Quercetin, kaempferol and isorhamnetin in Elaeagnus pungens Thunb. leaf: pharmacological activities and quantitative determination studies publication-title: Chem. Biodivers. doi: 10.1002/cbdv.201800129 – volume: 56 start-page: 2281 year: 2008 ident: 10.1016/j.exger.2024.112389_bb0510 article-title: Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH) publication-title: J. Agric. Food Chem. doi: 10.1021/jf073444o – volume: 2013 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0745 article-title: Chemistry and biological activities of flavonoids: an overview publication-title: Sci. World J. doi: 10.1155/2013/162750 – year: 2017 ident: 10.1016/j.exger.2024.112389_bb1165 – volume: 77 start-page: 789 year: 2020 ident: 10.1016/j.exger.2024.112389_bb0125 article-title: Senescence in the pathogenesis of age-related macular degeneration publication-title: Cellular and Molecular Life Sciences: CMLS. doi: 10.1007/s00018-019-03420-x – volume: 32 start-page: 489 year: 2009 ident: 10.1016/j.exger.2024.112389_bb0840 article-title: Synergistic effect of kaempferol glycosides purified from Laurus nobilis and fluoroquinolones on methicillin-resistant Staphylococcus aureus publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.32.489 – volume: 209 start-page: 114 year: 2005 ident: 10.1016/j.exger.2024.112389_bb1000 article-title: Protective and detrimental effects of kaempferol in rat H4IIE cells: implication of oxidative stress and apoptosis publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2005.04.004 – volume: 54 start-page: 1492 year: 1989 ident: 10.1016/j.exger.2024.112389_bb0355 article-title: Mutagenic flavonol aglycones in infusions and in fresh and pickled vegetables publication-title: J. Food Sci. doi: 10.1111/j.1365-2621.1989.tb05143.x – volume: 153 start-page: 1194 year: 2013 ident: 10.1016/j.exger.2024.112389_bb0875 article-title: The hallmarks of aging publication-title: Cell doi: 10.1016/j.cell.2013.05.039 – volume: 23 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0660 article-title: Chrysin induces apoptosis via the MAPK pathway and regulates ERK/mTOR-mediated autophagy in MC-3 cells publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms232415747 – volume: 72 start-page: 303 year: 2016 ident: 10.1016/j.exger.2024.112389_bb1435 article-title: Kaempferol inhibits the production of ROS to modulate OPN-αvβ3 integrin pathway in HUVECs publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-016-0479-3 – volume: 23 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1410 article-title: Cellular and gene expression response to the combination of genistein and kaempferol in the treatment of mucopolysaccharidosis type I publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms23031058 – volume: 19 start-page: 104 year: 2012 ident: 10.1016/j.exger.2024.112389_bb1235 article-title: Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates publication-title: J. Biomed. Sci. doi: 10.1186/1423-0127-19-104 – volume: 10 start-page: 2464 year: 2020 ident: 10.1016/j.exger.2024.112389_bb1545 article-title: Dysregulated metabolic pathways in age-related macular degeneration publication-title: Sci. Rep. doi: 10.1038/s41598-020-59244-4 – volume: 354 year: 2022 ident: 10.1016/j.exger.2024.112389_bb0030 article-title: Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2022.109842 – volume: 5 start-page: 371 year: 2021 ident: 10.1016/j.exger.2024.112389_bb0240 article-title: Exercise-associated pathways as novel neuroprotectants against CNS aging and Alzheimer’s disease publication-title: Innov. Aging doi: 10.1093/geroni/igab046.1440 – volume: 56 start-page: 105 year: 2015 ident: 10.1016/j.exger.2024.112389_bb0920 article-title: Blue LED light enhances growth, phytochemical contents, and antioxidant enzyme activities of Rehmannia glutinosa cultured in vitro publication-title: Hortic. Environ. Biotechnol. doi: 10.1007/s13580-015-0114-1 – volume: 22 start-page: 340 year: 2022 ident: 10.1016/j.exger.2024.112389_bb1400 article-title: Exploiting senescence for the treatment of cancer publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-022-00450-9 |
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| Title | Kaempferol: Paving the path for advanced treatments in aging-related diseases |
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