STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

• Published in: Development (Cambridge) Vol. 128; no. 11; pp. 2119 - 2129
• Main Authors: Sahni, M, Raz, R, Coffin, J D, Levy, D, Basilico, C
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.06.2001
• Subjects: Animals; Apoptosis; Bone Development; Cell Division; Chondrocytes - cytology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Dwarfism - etiology; Female; Fibroblast Growth Factor 2 - genetics; Fibroblast Growth Factor 2 - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Osteochondrodysplasias - etiology; Phenotype; Signal Transduction; Skull - cytology; STAT1 Transcription Factor; Trans-Activators - genetics; Trans-Activators - physiology

Unregulated FGF receptor signaling results in bone malformations that affect both endochondral and intramembranous ossification, and is the basis for several genetic forms of human dwarfism. FGF signaling inhibits chondrocyte proliferation and we have previously shown that the transcription factor S...