LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 23; no. 6; pp. 1018 - 1032
• Main Authors: Wei, Zhijian, Chen, Lei, Meng, Lei, Han, Wenxiu, Huang, Lei, Xu, Aman
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.11.2020; Springer Nature B.V
• Subjects: Abdominal Surgery; Adenocarcinoma; Bioinformatics; Cancer Research; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Collagen Type V - metabolism; Extracellular matrix; Gastric cancer; Gastroenterology; Genomes; Humans; Immunohistochemistry; Infiltration; Medicine; Medicine & Public Health; Metastases; MicroRNAs - metabolism; Neoplasm Metastasis - genetics; Nomograms; Oncology; Original Article; RNA, Long Noncoding - metabolism; Stomach Neoplasms - genetics; Surgical Oncology; Tumor Microenvironment - genetics; Up-Regulation - genetics; Western blotting; HOTAIR; COL5A1; Gastric cancer; MiR-1277-5p; Immune infiltration

Background Emerging studies have shown that HOTAIR acts as an oncogene in gastric cancer (GC). However, its role in the extracellular matrix and in tumor immune infiltration remains unknown. Methods HOTAIR and COL5A1 levels were analyzed by bioinformatics analysis and validated by qRT-PCR, western b...