Possible Neuropathology of Sleep Disturbance Linking to Alzheimer’s Disease: Astrocytic and Microglial Roles

• Published in: Frontiers in cellular neuroscience Vol. 16; p. 875138
• Main Authors: Xiao, Shu-Yun, Liu, Yi-Jie, Lu, Wang, Sha, Zhong-Wei, Xu, Che, Yu, Zhi-Hua, Lee, Shin-Da
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 09.06.2022; Frontiers Media S.A
• Subjects: Adenosine; Alzheimer's disease; amyloid beta; Apolipoprotein E; astrocyte; Astrocytes; Brain; Central nervous system; Cognitive ability; CX3CR1 protein; Dopamine; Electroencephalography; Eye movements; Genes; Glial fibrillary acidic protein; Homeostasis; IL-1β; Immune system; Inflammation; Interleukin 1; Interleukin 10; Interleukin 6; Microglia; Mutation; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neuroscience; Physiology; Proteins; Reviews; Serotonin; Sleep; Sleep deprivation; sleep disturbance; Tau protein; Tumor necrosis factor-α

Sleep disturbances not only deteriorate Alzheimer’s disease (AD) progress by affecting cognitive states but also accelerate the neuropathological changes of AD. Astrocytes and microglia are the principal players in the regulation of both sleep and AD. We proposed that possible astrocyte-mediated and...