MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation

• Published in: Cell death & disease Vol. 11; no. 4; p. 256
• Main Authors: Zheng, Jun, Chen, Liang, Lu, Tongyu, Zhang, Yingcai, Sui, Xin, Li, Yang, Huang, Xuna, He, Liying, Cai, Jianye, Zhou, Chaorong, Liang, Jinliang, Chen, Guihua, Yao, Jia, Yang, Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2020; Springer Nature B.V
• Subjects: 13/100; 13/109; 13/2; 13/21; 13/31; 13/51; 14/19; 14/28; 631/532/2074; 631/80/39/2348; 631/80/82/23; 82/80; 82/83; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Biochemistry; Biomedical and Life Sciences; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Cell Biology; Cell Culture; Culture Media, Conditioned - pharmacology; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Hypoxia; Immunology; Ischemia; Ischemia - metabolism; Life Sciences; Liver; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Male; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mesenchyme; Mice, Inbred C57BL; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitophagy; Mitophagy - drug effects; Parkin protein; PTEN-induced putative kinase; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reperfusion; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; siRNA; Stem cell transplantation; Stem cells

Hepatocyte apoptosis is the main pathophysiological process underlying liver ischemia/reperfusion (I/R) injury. Mitochondrial abnormalities have a vital role in hepatocellular damage. The hepatoprotective effects of mesenchymal stem cells (MSCs) have been previously demonstrated. In this study, we a...