Substrate-Dependent Functional Alterations of Seven CYP2C9 Variants Found in Japanese Subjects - Maekawa, Keiko; Harakawa, Noriko; Sugiyama, Emiko; Tohkin, Masahiro; Kim, Su-Ryang; Kaniwa, Nahoko; Katori, Noriko; Hasegawa, Ryuichi; Yasuda, Kazuki; Kamide, Kei; Miyata, Toshiyuki; Saito, Yoshiro; et al. (Drug metabolism and disposition, 2009)
Keywords: Alleles; Angiotensin II Type 1 Receptor Blockers - metabolism; Animals; Biological and medical sciences; Blotting, Western; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Diclofenac - metabolism; DNA, Complementary - biosynthesis; DNA, Complementary - genetics; Genetic Variation; Humans; Hypoglycemic Agents - metabolism; Insecta; Japan; Kinetics; Losartan - metabolism; Medical sciences; Microsomes - metabolism; Pharmacology. Drug treatments; Rats; Recombinant Proteins - metabolism; Substrate Specificity; Sulfonylurea Compounds - metabolism; Asia; Japan; Human; Substrate; Variant; Genetic variability; Enzyme; Isozyme; Cytochrome P450; Genotype; CYP2C9 gene