Up-Regulation of Endothelial Delta-like 4 Expression Correlates with Vessel Maturation in Bladder Cancer

• Published in: Clinical cancer research Vol. 12; no. 16; pp. 4836 - 4844
• Main Authors: PATEL, Nilay S, DOBBIE, Michael S, ROCHESTER, Mark, STEERS, Graham, POULSOM, Richard, LE MONNIER, Karena, CRANSTON, David W, LI, Ji-Liang, HARRIS, Adrian L
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.08.2006
• Subjects: Actins - biosynthesis; Actins - genetics; Adult; Aged; Aged, 80 and over; angiogenesis; Antigens, CD34 - biosynthesis; Antigens, CD34 - genetics; Antineoplastic agents; Biological and medical sciences; bladder cancer; Carcinoma, Transitional Cell - blood supply; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Cohort Studies; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Male; Medical sciences; Middle Aged; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Nephrology. Urinary tract diseases; Notch; Pharmacology. Drug treatments; Polymerase Chain Reaction; Prognosis; Tumors of the urinary system; Up-Regulation; Urinary Bladder Neoplasms - blood supply; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics; Endothelial cell; Urinary system disease; Blood vessel; Bladder disease; Circulatory system; Malignant tumor; Urinary tract disease; Gene expression; Bladder cancer; Endothelium

Purpose: Angiogenesis and vascular endothelial growth factor (VEGF) expression are associated with a poor outcome in bladder cancer. To understand more about the mechanisms, we studied the role of delta-like 4 (DLL4), an endothelial-specific ligand of the Notch signaling pathway, in bladder cancer a...